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How do oncoprotein mutations rewire protein–protein interaction networks?

How do oncoprotein mutations rewire protein–protein interaction networks?
How do oncoprotein mutations rewire protein–protein interaction networks?
The acquisition of mutations that activate oncogenes or inactivate tumor suppressors is a primary feature of most cancers. Mutations that directly alter protein sequence and structure drive the development of tumors through aberrant expression and modification of proteins, in many cases directly impacting components of signal transduction pathways and cellular architecture. Cancer-associated mutations may have direct or indirect effects on proteins and their interactions and while the effects of mutations on signaling pathways have been widely studied, how mutations alter underlying protein–protein interaction networks is much less well understood. Systematic mapping of oncoprotein protein interactions using proteomics techniques as well as computational network analyses is revealing how oncoprotein mutations perturb protein–protein interaction networks and drive the cancer phenotype
cancer, mutation, oncoprotein, protein–protein interaction, signaling network
449-455
Bowler, Emily
af2391ca-58c3-4b8b-b31b-2a7751577bd8
Wang, Zhenghe
9142416c-1981-4fa6-9fd7-e0a61a81fc33
Ewing, Rob
022c5b04-da20-4e55-8088-44d0dc9935ae
Bowler, Emily
af2391ca-58c3-4b8b-b31b-2a7751577bd8
Wang, Zhenghe
9142416c-1981-4fa6-9fd7-e0a61a81fc33
Ewing, Rob
022c5b04-da20-4e55-8088-44d0dc9935ae

Bowler, Emily, Wang, Zhenghe and Ewing, Rob (2015) How do oncoprotein mutations rewire protein–protein interaction networks? Expert Review of Proteomics, 12 (5), 449-455. (doi:10.1586/14789450.2015.1084875).

Record type: Article

Abstract

The acquisition of mutations that activate oncogenes or inactivate tumor suppressors is a primary feature of most cancers. Mutations that directly alter protein sequence and structure drive the development of tumors through aberrant expression and modification of proteins, in many cases directly impacting components of signal transduction pathways and cellular architecture. Cancer-associated mutations may have direct or indirect effects on proteins and their interactions and while the effects of mutations on signaling pathways have been widely studied, how mutations alter underlying protein–protein interaction networks is much less well understood. Systematic mapping of oncoprotein protein interactions using proteomics techniques as well as computational network analyses is revealing how oncoprotein mutations perturb protein–protein interaction networks and drive the cancer phenotype

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More information

Published date: 1 September 2015
Keywords: cancer, mutation, oncoprotein, protein–protein interaction, signaling network
Organisations: Molecular and Cellular

Identifiers

Local EPrints ID: 381122
URI: https://eprints.soton.ac.uk/id/eprint/381122
PURE UUID: 3e9a4b94-031e-4ed8-b3e3-87e0f0b1cf8f
ORCID for Rob Ewing: ORCID iD orcid.org/0000-0001-6510-4001

Catalogue record

Date deposited: 24 Sep 2015 12:49
Last modified: 20 Jul 2019 00:41

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