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Functional roles of fatty acids and their effects on human health

Functional roles of fatty acids and their effects on human health
Functional roles of fatty acids and their effects on human health
A variety of fatty acids exists in the diet of humans, in the bloodstream of humans, and in cells and tissues of humans. Fatty acids are energy sources and membrane constituents. They have biological activities that act to influence cell and tissue metabolism, function, and responsiveness to hormonal and other signals. The biological activities may be grouped as regulation of membrane structure and function; regulation of intracellular signaling pathways, transcription factor activity, and gene expression; and regulation of the production of bioactive lipid mediators. Through these effects, fatty acids influence health, well-being, and disease risk. The effects of saturated, cis monounsaturated, ?-6 and ?-3 polyunsaturated, and trans fatty acids are discussed. Although traditionally most interest in the health impact of fatty acids related to cardiovascular disease, it is now clear that fatty acids influence a range of other diseases, including metabolic diseases such as type 2 diabetes, inflammatory diseases, and cancer. Scientists, regulators, and communicators have described the biological effects and the health impacts of fatty acids according to fatty acid class. However, it is now obvious that within any fatty acid class, different members have different actions and effects. Thus, it would seem more appropriate to describe biological effects and health impacts of individual named fatty acids, although it is recognized that this would be a challenge when communicating outside of an academic environment (eg, to consumers)
fatty, acid, saturated, monounsaturated, polyunsaturated, trans, ?-3, fish oil, health, mechanism
0148-6071
18S-32S
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Calder, P. (2015) Functional roles of fatty acids and their effects on human health. Journal of Parenteral and Enteral Nutrition, 39 (1), 18S-32S. (doi:10.1177/0148607115595980). (PMID:26177664)

Record type: Article

Abstract

A variety of fatty acids exists in the diet of humans, in the bloodstream of humans, and in cells and tissues of humans. Fatty acids are energy sources and membrane constituents. They have biological activities that act to influence cell and tissue metabolism, function, and responsiveness to hormonal and other signals. The biological activities may be grouped as regulation of membrane structure and function; regulation of intracellular signaling pathways, transcription factor activity, and gene expression; and regulation of the production of bioactive lipid mediators. Through these effects, fatty acids influence health, well-being, and disease risk. The effects of saturated, cis monounsaturated, ?-6 and ?-3 polyunsaturated, and trans fatty acids are discussed. Although traditionally most interest in the health impact of fatty acids related to cardiovascular disease, it is now clear that fatty acids influence a range of other diseases, including metabolic diseases such as type 2 diabetes, inflammatory diseases, and cancer. Scientists, regulators, and communicators have described the biological effects and the health impacts of fatty acids according to fatty acid class. However, it is now obvious that within any fatty acid class, different members have different actions and effects. Thus, it would seem more appropriate to describe biological effects and health impacts of individual named fatty acids, although it is recognized that this would be a challenge when communicating outside of an academic environment (eg, to consumers)

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More information

Accepted/In Press date: 3 June 2015
Published date: September 2015
Keywords: fatty, acid, saturated, monounsaturated, polyunsaturated, trans, ?-3, fish oil, health, mechanism
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 381158
URI: https://eprints.soton.ac.uk/id/eprint/381158
ISSN: 0148-6071
PURE UUID: 7a1c4ee7-a65e-4b55-b314-e604d89600f8

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Date deposited: 05 Oct 2015 13:35
Last modified: 15 Jul 2019 21:06

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Author: P. Calder

University divisions

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