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Translational research in nephrology: chronic kidney disease prevention and public health

Translational research in nephrology: chronic kidney disease prevention and public health
Translational research in nephrology: chronic kidney disease prevention and public health
This narrative review evaluates translational research with respect to five important risk factors for chronic kidney disease (CKD): physical inactivity, high salt intake, smoking, diabetes and hypertension. We discuss the translational research around prevention of CKD and its complications both at the level of the general population, and at the level of those at high risk, i.e. people at increased risk for CKD or CKD complications. At the population level, all three lifestyle risk factors (physical inactivity, high salt intake and smoking) have been translated into implemented measures and clear population health improvements have been observed. At the ‘high-risk’ level, the lifestyle studies reviewed have tended to focus on the individual impact of specific interventions, and their wider implementation and impact on CKD practice are more difficult to establish. The treatment of both diabetes and hypertension appears to have improved, however the impact on CKD and CKD complications was not always clear. Future studies need to investigate the most effective translational interventions in low and middle income countries.
CKD, diabetes mellitus, epidemiology, hypertension, physical activity
2048-8513
1-9
Bruck, K.
5313925f-1d5c-4d3f-9e4e-d32370a75fa6
Stel, V.S.
8da401ce-8574-495e-bd0a-d96d1d21d8b5
Fraser, SDS
135884b6-8737-4e8a-a98c-5d803ac7a2dc
De Goeij, M.C.M.
45f8dff3-70b7-4c81-a1ab-be6dac2aa80b
Caskey, F.
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Abu-Hanna, A.
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Jager, K.J.
c03856d6-b43d-4b77-b235-56e48c9c868f
Bruck, K.
5313925f-1d5c-4d3f-9e4e-d32370a75fa6
Stel, V.S.
8da401ce-8574-495e-bd0a-d96d1d21d8b5
Fraser, SDS
135884b6-8737-4e8a-a98c-5d803ac7a2dc
De Goeij, M.C.M.
45f8dff3-70b7-4c81-a1ab-be6dac2aa80b
Caskey, F.
f6293029-8bb4-4fff-893b-ed77be41ffc4
Abu-Hanna, A.
23f23c8c-1991-4df9-845e-c0c9b6c23d98
Jager, K.J.
c03856d6-b43d-4b77-b235-56e48c9c868f

Bruck, K., Stel, V.S., Fraser, SDS, De Goeij, M.C.M., Caskey, F., Abu-Hanna, A. and Jager, K.J. (2015) Translational research in nephrology: chronic kidney disease prevention and public health. Clinical Kidney Journal, 1-9. (doi:10.1093/ckj/sfv082).

Record type: Article

Abstract

This narrative review evaluates translational research with respect to five important risk factors for chronic kidney disease (CKD): physical inactivity, high salt intake, smoking, diabetes and hypertension. We discuss the translational research around prevention of CKD and its complications both at the level of the general population, and at the level of those at high risk, i.e. people at increased risk for CKD or CKD complications. At the population level, all three lifestyle risk factors (physical inactivity, high salt intake and smoking) have been translated into implemented measures and clear population health improvements have been observed. At the ‘high-risk’ level, the lifestyle studies reviewed have tended to focus on the individual impact of specific interventions, and their wider implementation and impact on CKD practice are more difficult to establish. The treatment of both diabetes and hypertension appears to have improved, however the impact on CKD and CKD complications was not always clear. Future studies need to investigate the most effective translational interventions in low and middle income countries.

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More information

Accepted/In Press date: 3 August 2015
e-pub ahead of print date: 30 August 2015
Keywords: CKD, diabetes mellitus, epidemiology, hypertension, physical activity
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 381188
URI: http://eprints.soton.ac.uk/id/eprint/381188
ISSN: 2048-8513
PURE UUID: 8c6fc3d8-b1e4-4d15-931b-9b2f3b200d8d
ORCID for SDS Fraser: ORCID iD orcid.org/0000-0002-4172-4406

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Date deposited: 14 Sep 2015 14:54
Last modified: 12 Nov 2019 01:43

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