The University of Southampton
University of Southampton Institutional Repository

Towards host-directed therapies for tuberculosis

Towards host-directed therapies for tuberculosis
Towards host-directed therapies for tuberculosis
The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.
1474-1776
511-512
Zumla, A.
68d40632-8be6-448f-8188-090814d287b8
Chakaya, J.
1d3d0e7b-f14f-4f36-9244-4b3d0752e95f
Hoelscher, M.
5b86bf92-801f-4ae4-872e-537277226995
Ntoumi, F.
8731ac57-d80e-4ebb-b653-be00175b02e4
Rustomjee, R.
58112c27-3c9e-4f4d-a1de-a518298a7fd0
Vilaplana, C.
fcc91ba7-0b47-4a75-9918-1e8f3c08c708
Yeboah-Manu, D.
65a5458e-9482-49cd-a4cc-9db229dba97e
Rasolof, V.
d71c9e67-af1a-4f54-b170-ddcd319646d1
Munderi, P.
d041bdf7-efd2-49dc-b4af-a59a6d8b95b4
Singh, N.
61b48ffd-0119-4510-b1f3-5dc577dd4ef3
Aklillu, E.
594f166e-83f9-460f-8df7-5fd7af439685
Padayatchi, N.
0c4e4a2d-6018-4f7b-8bfc-9ccbbf26fb6f
Macete, E.
79e89b43-008c-4c14-8fba-6b79e531226b
Kapata, N.
c78777cc-094b-4a62-b43e-e9da22b1b6b9
Mulenga, M.
51fa2a09-8569-47d3-8029-95d153de10f4
Kibiki, G.
c80ac26f-1e10-4057-9d1e-8b987258a6b6
Mfinanga, S.
e4b4ad0f-39ad-43ab-86a7-da9fc07551b3
Nyirenda, T.
a989c978-6bed-4c58-b0f3-761192456465
Maboko, L.
866be5e9-2bde-4103-8358-09046259e912
Garcia-Basteiro, A.
f52d6e3f-3eff-4958-b49d-1ade0e06aedf
Rakotosamimanana, N.
11282650-31db-46ea-aa71-29cfa729c66f
Bates, M.
92d85ac6-ac87-49f1-ab95-b67ef97e047c
Mwaba, P.
841f4e0c-8c0c-4ce4-b4e8-a079cf49a8b0
Reither, K.
b71a056c-bbeb-47aa-aef6-9d8b39a2b5a3
Gagneux, S.
cfefd08c-7d66-44ff-bcd3-0bb99bfd12ef
Edwards, S.
340b6435-5d2e-4eec-bb37-a67ccb66355d
Mfinanga, E.
2e94a909-4a0b-4df2-94ca-55d6f7d640e3
Abdulla, S.
95e1a7d0-126b-479c-96d0-45d0dc71ab42
Cardona, P.J.
ac9a23c5-b4e5-41c2-b7c2-9b4a53cc5609
Russell, J.B.
8e31975c-d802-469e-8d50-cbed9ea7c13c
Gant, V.
bbb3de2f-6381-40a1-92e3-4d1eff42e2e6
Noursadeghi, M.
7ef3936d-5d26-491a-8419-19711866e6cc
Elkington, P.T.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Bonnet, M.
824af037-6159-424d-957c-7d520c15b0cb
Menendez, C.
450735ac-5618-4d70-96f7-cbc903fd06e2
Dieye, T.N.
93305f4f-7815-46dc-95d2-65fbf6bd33b7
Diarra, B.
954f8c57-63ad-4c85-ae5e-3e43e12835b1
Maiga, A.
ba9cc1c1-4a5f-4b11-85b7-cba67d13cba7
Aseffa, A.
2e5c8eec-9252-47e4-ae70-e8f9ce0f91ad
Parida, S.
1e195723-03a4-4c74-a8fa-d413b0a5badf
Wejse, C.
33dc81e6-7551-4ec8-b2db-c8c477a21f20
Petersen, E.
72ad44ef-52da-4361-9ac1-58fa19af99ab
Kaleebu, P.
444c4bbf-0301-464c-a392-f633665329d1
Oliver, M.
f9b2a388-5c7a-4e10-a4ac-56bd0ecd8771
Craig, G.
38e82f20-eb10-4922-a5b8-70c1442c1219
Corrah, T.
2453b490-0dfd-4e97-88d2-7812d6513e9e
Tientcheu, L.
a849961a-3d25-47b6-a394-fb1ebfe6bd1d
Antonio, M.
53338f47-d414-4415-86b4-49e57abc585a
Rao, M.
93610fd2-a2e1-435e-8d53-d97d8fec75b0
McHugh, T.D.
68ecc8b4-8354-49c1-85c3-9f4c81b43f93
Sheikh, A.
f34621ac-f425-42fd-81e3-2057b1c9ce2f
Ippolito, G.
91249054-6298-44df-8680-c783c50b8803
Ramjee, G.
ff85de4f-03d6-42db-820d-0ee92d43b5df
Kaufmann, S.H.
4b838d3f-40d7-47da-b85d-da6a4163c540
Churchyard, G.
388fb00a-0051-4d51-a853-58c02b23ee03
Steyn, A.
29105af9-edde-486b-8b18-f0b18544580d
Grobusch, M.
9729ba77-2cd0-4655-8c25-bdea55321f9a
Sanne, I.
77bef87c-f099-47b0-a535-ef5f69f303e2
Martinson, N.
c4dffb83-cae8-4b60-a227-6d761355af06
Madansein, R.
32c96ca9-27e3-4bc7-bd8b-0564c454aec8
Wilkinson, R.J.
d08be0b9-dbe4-46c5-9297-68733a4e2f9f
Mayosi, B.
5d6fe316-f31e-4ef4-8c0f-95a8ddb9ff5a
Schito, M.
0298b420-8fdb-4e3b-b25e-34541aedce4a
Wallis, R.S.
eed31ed6-12ce-4dad-ad0e-d9a6b35044af
Maeurer, M.
c470bfa6-f030-4fbf-a766-c2f3333b5cc1
Zumla, A.
68d40632-8be6-448f-8188-090814d287b8
Chakaya, J.
1d3d0e7b-f14f-4f36-9244-4b3d0752e95f
Hoelscher, M.
5b86bf92-801f-4ae4-872e-537277226995
Ntoumi, F.
8731ac57-d80e-4ebb-b653-be00175b02e4
Rustomjee, R.
58112c27-3c9e-4f4d-a1de-a518298a7fd0
Vilaplana, C.
fcc91ba7-0b47-4a75-9918-1e8f3c08c708
Yeboah-Manu, D.
65a5458e-9482-49cd-a4cc-9db229dba97e
Rasolof, V.
d71c9e67-af1a-4f54-b170-ddcd319646d1
Munderi, P.
d041bdf7-efd2-49dc-b4af-a59a6d8b95b4
Singh, N.
61b48ffd-0119-4510-b1f3-5dc577dd4ef3
Aklillu, E.
594f166e-83f9-460f-8df7-5fd7af439685
Padayatchi, N.
0c4e4a2d-6018-4f7b-8bfc-9ccbbf26fb6f
Macete, E.
79e89b43-008c-4c14-8fba-6b79e531226b
Kapata, N.
c78777cc-094b-4a62-b43e-e9da22b1b6b9
Mulenga, M.
51fa2a09-8569-47d3-8029-95d153de10f4
Kibiki, G.
c80ac26f-1e10-4057-9d1e-8b987258a6b6
Mfinanga, S.
e4b4ad0f-39ad-43ab-86a7-da9fc07551b3
Nyirenda, T.
a989c978-6bed-4c58-b0f3-761192456465
Maboko, L.
866be5e9-2bde-4103-8358-09046259e912
Garcia-Basteiro, A.
f52d6e3f-3eff-4958-b49d-1ade0e06aedf
Rakotosamimanana, N.
11282650-31db-46ea-aa71-29cfa729c66f
Bates, M.
92d85ac6-ac87-49f1-ab95-b67ef97e047c
Mwaba, P.
841f4e0c-8c0c-4ce4-b4e8-a079cf49a8b0
Reither, K.
b71a056c-bbeb-47aa-aef6-9d8b39a2b5a3
Gagneux, S.
cfefd08c-7d66-44ff-bcd3-0bb99bfd12ef
Edwards, S.
340b6435-5d2e-4eec-bb37-a67ccb66355d
Mfinanga, E.
2e94a909-4a0b-4df2-94ca-55d6f7d640e3
Abdulla, S.
95e1a7d0-126b-479c-96d0-45d0dc71ab42
Cardona, P.J.
ac9a23c5-b4e5-41c2-b7c2-9b4a53cc5609
Russell, J.B.
8e31975c-d802-469e-8d50-cbed9ea7c13c
Gant, V.
bbb3de2f-6381-40a1-92e3-4d1eff42e2e6
Noursadeghi, M.
7ef3936d-5d26-491a-8419-19711866e6cc
Elkington, P.T.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Bonnet, M.
824af037-6159-424d-957c-7d520c15b0cb
Menendez, C.
450735ac-5618-4d70-96f7-cbc903fd06e2
Dieye, T.N.
93305f4f-7815-46dc-95d2-65fbf6bd33b7
Diarra, B.
954f8c57-63ad-4c85-ae5e-3e43e12835b1
Maiga, A.
ba9cc1c1-4a5f-4b11-85b7-cba67d13cba7
Aseffa, A.
2e5c8eec-9252-47e4-ae70-e8f9ce0f91ad
Parida, S.
1e195723-03a4-4c74-a8fa-d413b0a5badf
Wejse, C.
33dc81e6-7551-4ec8-b2db-c8c477a21f20
Petersen, E.
72ad44ef-52da-4361-9ac1-58fa19af99ab
Kaleebu, P.
444c4bbf-0301-464c-a392-f633665329d1
Oliver, M.
f9b2a388-5c7a-4e10-a4ac-56bd0ecd8771
Craig, G.
38e82f20-eb10-4922-a5b8-70c1442c1219
Corrah, T.
2453b490-0dfd-4e97-88d2-7812d6513e9e
Tientcheu, L.
a849961a-3d25-47b6-a394-fb1ebfe6bd1d
Antonio, M.
53338f47-d414-4415-86b4-49e57abc585a
Rao, M.
93610fd2-a2e1-435e-8d53-d97d8fec75b0
McHugh, T.D.
68ecc8b4-8354-49c1-85c3-9f4c81b43f93
Sheikh, A.
f34621ac-f425-42fd-81e3-2057b1c9ce2f
Ippolito, G.
91249054-6298-44df-8680-c783c50b8803
Ramjee, G.
ff85de4f-03d6-42db-820d-0ee92d43b5df
Kaufmann, S.H.
4b838d3f-40d7-47da-b85d-da6a4163c540
Churchyard, G.
388fb00a-0051-4d51-a853-58c02b23ee03
Steyn, A.
29105af9-edde-486b-8b18-f0b18544580d
Grobusch, M.
9729ba77-2cd0-4655-8c25-bdea55321f9a
Sanne, I.
77bef87c-f099-47b0-a535-ef5f69f303e2
Martinson, N.
c4dffb83-cae8-4b60-a227-6d761355af06
Madansein, R.
32c96ca9-27e3-4bc7-bd8b-0564c454aec8
Wilkinson, R.J.
d08be0b9-dbe4-46c5-9297-68733a4e2f9f
Mayosi, B.
5d6fe316-f31e-4ef4-8c0f-95a8ddb9ff5a
Schito, M.
0298b420-8fdb-4e3b-b25e-34541aedce4a
Wallis, R.S.
eed31ed6-12ce-4dad-ad0e-d9a6b35044af
Maeurer, M.
c470bfa6-f030-4fbf-a766-c2f3333b5cc1

Zumla, A., Chakaya, J., Hoelscher, M., Ntoumi, F., Rustomjee, R., Vilaplana, C., Yeboah-Manu, D., Rasolof, V., Munderi, P., Singh, N., Aklillu, E., Padayatchi, N., Macete, E., Kapata, N., Mulenga, M., Kibiki, G., Mfinanga, S., Nyirenda, T., Maboko, L., Garcia-Basteiro, A., Rakotosamimanana, N., Bates, M., Mwaba, P., Reither, K., Gagneux, S., Edwards, S., Mfinanga, E., Abdulla, S., Cardona, P.J., Russell, J.B., Gant, V., Noursadeghi, M., Elkington, P.T., Bonnet, M., Menendez, C., Dieye, T.N., Diarra, B., Maiga, A., Aseffa, A., Parida, S., Wejse, C., Petersen, E., Kaleebu, P., Oliver, M., Craig, G., Corrah, T., Tientcheu, L., Antonio, M., Rao, M., McHugh, T.D., Sheikh, A., Ippolito, G., Ramjee, G., Kaufmann, S.H., Churchyard, G., Steyn, A., Grobusch, M., Sanne, I., Martinson, N., Madansein, R., Wilkinson, R.J., Mayosi, B., Schito, M., Wallis, R.S. and Maeurer, M. (2015) Towards host-directed therapies for tuberculosis. Nature Reviews. Drug Discovery, 14, 511-512. (doi:10.1038/nrd4696). (PMID:26184493)

Record type: Article

Abstract

The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

This record has no associated files available for download.

More information

e-pub ahead of print date: 17 July 2015
Published date: August 2015
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 381233
URI: http://eprints.soton.ac.uk/id/eprint/381233
ISSN: 1474-1776
PURE UUID: 20469090-4bd0-47a6-ab82-45ce0a1cf890
ORCID for P.T. Elkington: ORCID iD orcid.org/0000-0003-0390-0613

Catalogue record

Date deposited: 02 Oct 2015 14:33
Last modified: 15 Mar 2024 03:43

Export record

Altmetrics

Contributors

Author: A. Zumla
Author: J. Chakaya
Author: M. Hoelscher
Author: F. Ntoumi
Author: R. Rustomjee
Author: C. Vilaplana
Author: D. Yeboah-Manu
Author: V. Rasolof
Author: P. Munderi
Author: N. Singh
Author: E. Aklillu
Author: N. Padayatchi
Author: E. Macete
Author: N. Kapata
Author: M. Mulenga
Author: G. Kibiki
Author: S. Mfinanga
Author: T. Nyirenda
Author: L. Maboko
Author: A. Garcia-Basteiro
Author: N. Rakotosamimanana
Author: M. Bates
Author: P. Mwaba
Author: K. Reither
Author: S. Gagneux
Author: S. Edwards
Author: E. Mfinanga
Author: S. Abdulla
Author: P.J. Cardona
Author: J.B. Russell
Author: V. Gant
Author: M. Noursadeghi
Author: P.T. Elkington ORCID iD
Author: M. Bonnet
Author: C. Menendez
Author: T.N. Dieye
Author: B. Diarra
Author: A. Maiga
Author: A. Aseffa
Author: S. Parida
Author: C. Wejse
Author: E. Petersen
Author: P. Kaleebu
Author: M. Oliver
Author: G. Craig
Author: T. Corrah
Author: L. Tientcheu
Author: M. Antonio
Author: M. Rao
Author: T.D. McHugh
Author: A. Sheikh
Author: G. Ippolito
Author: G. Ramjee
Author: S.H. Kaufmann
Author: G. Churchyard
Author: A. Steyn
Author: M. Grobusch
Author: I. Sanne
Author: N. Martinson
Author: R. Madansein
Author: R.J. Wilkinson
Author: B. Mayosi
Author: M. Schito
Author: R.S. Wallis
Author: M. Maeurer

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×