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Smaller size at birth in South Asians: findings from the Born in Bradford birth cohort study

Smaller size at birth in South Asians: findings from the Born in Bradford birth cohort study
Smaller size at birth in South Asians: findings from the Born in Bradford birth cohort study
Background
Rates of advanced chronic kidney disease and renal replacement therapy are higher in South Asian than in white British populations. Low birth weight is also more frequent in South Asian populations and has been associated with increased risks of kidney disease, perhaps due to a reduced nephron endowment.

Methods
Using ultrasound scans at 34 weeks of gestation, we measured fetal kidney dimensions (transverse and anteroposterior diameters, length and circumference) and derived volume in a random sample of 872 white British and 715 South Asian participants in the Born in Bradford cohort study. Kidney measurements were compared between ethnic groups.

Results
Birth weight for gestational age at 40 weeks was 200 g less in South Asian babies compared with white British babies. The mean kidney volume for gestational age was 16% lower in South Asian than in white British babies [8.79 versus 10.45 cm3, difference 1.66 cm3 (95% confidence interval 1.40–1.93, P < 0.001)]. The difference was robust after adjustment for maternal age, socio-economic factors, marital status, body mass index, smoking and alcohol use in pregnancy, parity, baby's gender and birth weight for gestational age [adjusted difference 1.38 cm3 (0.97–1.84), P < 0.001]. There were smaller reductions in other fetal measures.

Conclusion
South Asian babies have smaller kidneys compared with white British babies, even after adjusting for potential confounders including birth weight. This finding may contribute to increased risks of adult kidney disease in South Asian populations.
fetal development, kidney volume, south asian
0931-0509
455-465
Roderick, Paul J.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Jeffrey, Robin F. Jeffrey
538dbbda-660c-4f2c-8c27-3e65ac9c9c29
Yuen, Ho M.
b1df4c57-0c2a-44ac-ab40-22b88e8effe8
Godfrey, Keith M.
4bcf393c-4127-4c3b-a32d-16fc96f2a088
West, Jane
f6167eb2-7e11-49db-80f0-57e611b20a1f
Wright, John
5d3dba6c-c81f-4393-8b28-d4195e9efefa
Roderick, Paul J.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Jeffrey, Robin F. Jeffrey
538dbbda-660c-4f2c-8c27-3e65ac9c9c29
Yuen, Ho M.
b1df4c57-0c2a-44ac-ab40-22b88e8effe8
Godfrey, Keith M.
4bcf393c-4127-4c3b-a32d-16fc96f2a088
West, Jane
f6167eb2-7e11-49db-80f0-57e611b20a1f
Wright, John
5d3dba6c-c81f-4393-8b28-d4195e9efefa

Roderick, Paul J., Jeffrey, Robin F. Jeffrey, Yuen, Ho M., Godfrey, Keith M., West, Jane and Wright, John (2016) Smaller size at birth in South Asians: findings from the Born in Bradford birth cohort study. Nephrology, Dialysis, Transplantation, 31 (3), 455-465. (doi:10.1093/ndt/gfv274). (PMID:26209714)

Record type: Article

Abstract

Background
Rates of advanced chronic kidney disease and renal replacement therapy are higher in South Asian than in white British populations. Low birth weight is also more frequent in South Asian populations and has been associated with increased risks of kidney disease, perhaps due to a reduced nephron endowment.

Methods
Using ultrasound scans at 34 weeks of gestation, we measured fetal kidney dimensions (transverse and anteroposterior diameters, length and circumference) and derived volume in a random sample of 872 white British and 715 South Asian participants in the Born in Bradford cohort study. Kidney measurements were compared between ethnic groups.

Results
Birth weight for gestational age at 40 weeks was 200 g less in South Asian babies compared with white British babies. The mean kidney volume for gestational age was 16% lower in South Asian than in white British babies [8.79 versus 10.45 cm3, difference 1.66 cm3 (95% confidence interval 1.40–1.93, P < 0.001)]. The difference was robust after adjustment for maternal age, socio-economic factors, marital status, body mass index, smoking and alcohol use in pregnancy, parity, baby's gender and birth weight for gestational age [adjusted difference 1.38 cm3 (0.97–1.84), P < 0.001]. There were smaller reductions in other fetal measures.

Conclusion
South Asian babies have smaller kidneys compared with white British babies, even after adjusting for potential confounders including birth weight. This finding may contribute to increased risks of adult kidney disease in South Asian populations.

Full text not available from this repository.

More information

Accepted/In Press date: 12 June 2015
e-pub ahead of print date: 23 July 2015
Published date: March 2016
Keywords: fetal development, kidney volume, south asian
Organisations: MRC Life-Course Epidemiology Unit

Identifiers

Local EPrints ID: 381288
URI: https://eprints.soton.ac.uk/id/eprint/381288
ISSN: 0931-0509
PURE UUID: 542f10c5-684e-4b8b-b853-3bd749c380a2
ORCID for Paul J. Roderick: ORCID iD orcid.org/0000-0001-9475-6850

Catalogue record

Date deposited: 01 Oct 2015 10:57
Last modified: 19 Nov 2019 01:58

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