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HIF3A association with adiposity: the story begins before birth

HIF3A association with adiposity: the story begins before birth
HIF3A association with adiposity: the story begins before birth
Aim: determine if the association of HIF3A DNA methylation with weight and adiposity is detectable early in life.

Material & methods: we determined HIF3A genotype and DNA methylation patterns (on hybridization arrays) in DNA extracted from umbilical cords of 991 infants. Methylation levels at three CpGs in the HIF3A first intron were related to neonatal and infant anthropometry and to genotype at nearby polymorphic sites.

Results & conclusion: higher methylation levels at three previously described HIF3A CpGs were associated with greater infant weight and adiposity. The effect sizes were slightly smaller than those reported for adult BMI. There was also an interaction within cis-genotype. The association between higher DNA methylation at HIF3A and increased adiposity is present in neonates. In this study, no particular prenatal factor strongly influenced HIF3A hypermethylation. Our data nonetheless suggest shared prenatal influences on HIF3A methylation and adiposity
1750-1911
937-950
Pan, H.
c3e588e4-072e-4f05-802a-ab6d47d7358a
Lin, X.
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Wu, Y.
84854e37-ada6-4cc8-995f-6ce5ebc77423
Chen, L.
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Teh, A.L.
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Soh, S.E.
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Lee, Y.S.
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Tint, M.T.
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MacIssac, J.L.
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Morin, A.M.
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Tan, K.H.
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Yap, F.
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Saw, S.M.
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Kobor, M.S.
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Meaney, M.J.
cb875853-8497-4382-9aff-739714aa49f9
Godfrey, K.M.
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Chong, Y.S.
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Gluckman, P.D.
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Karnani, N.
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Holbrook, J.D.
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Pan, H.
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Lin, X.
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Wu, Y.
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Chen, L.
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Teh, A.L.
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Soh, S.E.
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Lee, Y.S.
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Tint, M.T.
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MacIssac, J.L.
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Morin, A.M.
ce83308b-b7df-4ea5-94b2-b45c70e877c9
Tan, K.H.
d1d689a8-cf28-4669-8493-b3f8fc704882
Yap, F.
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Saw, S.M.
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Kobor, M.S.
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Meaney, M.J.
cb875853-8497-4382-9aff-739714aa49f9
Godfrey, K.M.
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Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Karnani, N.
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Holbrook, J.D.
b21c1caa-5630-42f6-8bc8-34954ce8a75a

Pan, H., Lin, X., Wu, Y., Chen, L., Teh, A.L., Soh, S.E., Lee, Y.S., Tint, M.T., MacIssac, J.L., Morin, A.M., Tan, K.H., Yap, F., Saw, S.M., Kobor, M.S., Meaney, M.J., Godfrey, K.M., Chong, Y.S., Gluckman, P.D., Karnani, N. and Holbrook, J.D. (2015) HIF3A association with adiposity: the story begins before birth. Epigenomics, 7 (6), 937-950. (doi:10.2217/epi.15.45). (PMID:26011824)

Record type: Article

Abstract

Aim: determine if the association of HIF3A DNA methylation with weight and adiposity is detectable early in life.

Material & methods: we determined HIF3A genotype and DNA methylation patterns (on hybridization arrays) in DNA extracted from umbilical cords of 991 infants. Methylation levels at three CpGs in the HIF3A first intron were related to neonatal and infant anthropometry and to genotype at nearby polymorphic sites.

Results & conclusion: higher methylation levels at three previously described HIF3A CpGs were associated with greater infant weight and adiposity. The effect sizes were slightly smaller than those reported for adult BMI. There was also an interaction within cis-genotype. The association between higher DNA methylation at HIF3A and increased adiposity is present in neonates. In this study, no particular prenatal factor strongly influenced HIF3A hypermethylation. Our data nonetheless suggest shared prenatal influences on HIF3A methylation and adiposity

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epi.15.45 - Version of Record
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Submitted date: 26 May 2015
Published date: September 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 381460
URI: http://eprints.soton.ac.uk/id/eprint/381460
ISSN: 1750-1911
PURE UUID: c825b2ac-5a50-4d6d-bcc8-9e4be3e496bf
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 12 Oct 2015 10:39
Last modified: 07 Oct 2020 01:35

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Contributors

Author: H. Pan
Author: X. Lin
Author: Y. Wu
Author: L. Chen
Author: A.L. Teh
Author: S.E. Soh
Author: Y.S. Lee
Author: M.T. Tint
Author: J.L. MacIssac
Author: A.M. Morin
Author: K.H. Tan
Author: F. Yap
Author: S.M. Saw
Author: M.S. Kobor
Author: M.J. Meaney
Author: K.M. Godfrey ORCID iD
Author: Y.S. Chong
Author: P.D. Gluckman
Author: N. Karnani
Author: J.D. Holbrook

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