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The ‘Developmental Origins’ hypothesis: relevance to the obstetrician and gynecologist

The ‘Developmental Origins’ hypothesis: relevance to the obstetrician and gynecologist
The ‘Developmental Origins’ hypothesis: relevance to the obstetrician and gynecologist
The recognition of ‘fetal origins of adult disease’ has placed new responsibilities on the obstetrician, as antenatal care is no longer simply about ensuring good perinatal outcomes, but also needs to plan for optimal long-term health for mother and baby. Recently, it has become clear that the intrauterine environment has a broad and long-lasting impact, influencing fetal and childhood growth and development as well as future cardiovascular health, non-communicable disease risk and fertility. This article looks specifically at the importance of the developmental origins of ovarian reserve and ageing, the role of the placenta and maternal nutrition before and during pregnancy. It also reviews recent insights in developmental medicine of relevance to the obstetrician, and outlines emerging evidence supporting a proactive clinical approach to optimizing periconceptional as well as antenatal care aimed to protect newborns against long-term disease susceptibility.
developmental origins, ovary, placenta, pregnancy
415-424
Kermack, A.
b9294c93-c736-4505-abe4-78bee493f1c2
van Rijn, B.
c958dfb5-2010-46de-a350-4903295ac340
Houghton, F.D.
53946041-127e-45a8-9edb-bf4b3c23005f
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cameron, I.T.
f7595539-efa6-4687-b161-e1e93ff710f2
Macklon, N.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Kermack, A.
b9294c93-c736-4505-abe4-78bee493f1c2
van Rijn, B.
c958dfb5-2010-46de-a350-4903295ac340
Houghton, F.D.
53946041-127e-45a8-9edb-bf4b3c23005f
Calder, P.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cameron, I.T.
f7595539-efa6-4687-b161-e1e93ff710f2
Macklon, N.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e

Kermack, A., van Rijn, B., Houghton, F.D., Calder, P., Cameron, I.T. and Macklon, N. (2015) The ‘Developmental Origins’ hypothesis: relevance to the obstetrician and gynecologist. Journal of Developmental Origins of Health and Disease, 6 (5), 415-424. (doi:10.1017/S2040174415001324). (PMID:26347389)

Record type: Article

Abstract

The recognition of ‘fetal origins of adult disease’ has placed new responsibilities on the obstetrician, as antenatal care is no longer simply about ensuring good perinatal outcomes, but also needs to plan for optimal long-term health for mother and baby. Recently, it has become clear that the intrauterine environment has a broad and long-lasting impact, influencing fetal and childhood growth and development as well as future cardiovascular health, non-communicable disease risk and fertility. This article looks specifically at the importance of the developmental origins of ovarian reserve and ageing, the role of the placenta and maternal nutrition before and during pregnancy. It also reviews recent insights in developmental medicine of relevance to the obstetrician, and outlines emerging evidence supporting a proactive clinical approach to optimizing periconceptional as well as antenatal care aimed to protect newborns against long-term disease susceptibility.

Full text not available from this repository.

More information

Accepted/In Press date: 11 June 2015
e-pub ahead of print date: 8 September 2015
Published date: October 2015
Keywords: developmental origins, ovary, placenta, pregnancy
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 381498
URI: http://eprints.soton.ac.uk/id/eprint/381498
PURE UUID: 0ff72bd9-acfb-448e-8c86-a6429b69f608
ORCID for A. Kermack: ORCID iD orcid.org/0000-0002-9176-9426
ORCID for F.D. Houghton: ORCID iD orcid.org/0000-0002-5167-1694
ORCID for P. Calder: ORCID iD orcid.org/0000-0002-6038-710X
ORCID for I.T. Cameron: ORCID iD orcid.org/0000-0002-4875-267X

Catalogue record

Date deposited: 08 Oct 2015 08:28
Last modified: 17 Apr 2021 02:03

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