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Unified model of hyperthermia via hysteresis heating in systems of interacting magnetic nanoparticles

Unified model of hyperthermia via hysteresis heating in systems of interacting magnetic nanoparticles
Unified model of hyperthermia via hysteresis heating in systems of interacting magnetic nanoparticles
We present a general study of the frequency and magnetic field dependence of the specific heat power produced during field-driven hysteresis cycles in magnetic nanoparticles with relevance to hyperthermia applications in biomedicine. Employing a kinetic Monte-Carlo method with natural time scales allows us to go beyond the assumptions of small driving field amplitudes and negligible inter-particle interactions, which are fundamental to the applicability of the standard approach based on linear response theory. The method captures the superparamagnetic and fully hysteretic regimes and the transition between them. Our results reveal unexpected dipolar interaction-induced enhancement or suppression of the specific heat power, dependent on the intrinsic statistical properties of particles, which cannot be accounted for by the standard theory. Although the actual heating power is difficult to predict because of the effects of interactions, optimum heating is in the transition region between the superparamagnetic and fully hysteretic regimes.
nanoparticles, nanoparticles - hyperthermia
Ruta, S.
2b4868a0-a3ed-42cd-8f55-cfcd3ae3095b
Chantrell, R.
198af296-a739-42f0-9908-7e4ac4c9e45e
Hovorka, O.
a12bd550-ad45-4963-aa26-dd81dd1609ee
Ruta, S.
2b4868a0-a3ed-42cd-8f55-cfcd3ae3095b
Chantrell, R.
198af296-a739-42f0-9908-7e4ac4c9e45e
Hovorka, O.
a12bd550-ad45-4963-aa26-dd81dd1609ee

Ruta, S., Chantrell, R. and Hovorka, O. (2015) Unified model of hyperthermia via hysteresis heating in systems of interacting magnetic nanoparticles. Scientific Reports, 5, [9090]. (doi:10.1038/srep09090).

Record type: Article

Abstract

We present a general study of the frequency and magnetic field dependence of the specific heat power produced during field-driven hysteresis cycles in magnetic nanoparticles with relevance to hyperthermia applications in biomedicine. Employing a kinetic Monte-Carlo method with natural time scales allows us to go beyond the assumptions of small driving field amplitudes and negligible inter-particle interactions, which are fundamental to the applicability of the standard approach based on linear response theory. The method captures the superparamagnetic and fully hysteretic regimes and the transition between them. Our results reveal unexpected dipolar interaction-induced enhancement or suppression of the specific heat power, dependent on the intrinsic statistical properties of particles, which cannot be accounted for by the standard theory. Although the actual heating power is difficult to predict because of the effects of interactions, optimum heating is in the transition region between the superparamagnetic and fully hysteretic regimes.

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Accepted/In Press date: 9 February 2015
e-pub ahead of print date: 13 March 2015
Published date: 13 March 2015
Keywords: nanoparticles, nanoparticles - hyperthermia
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 381838
URI: http://eprints.soton.ac.uk/id/eprint/381838
PURE UUID: 0169f1db-68ca-423b-88c5-176fd5492629
ORCID for O. Hovorka: ORCID iD orcid.org/0000-0002-6707-4325

Catalogue record

Date deposited: 30 Sep 2015 16:23
Last modified: 18 Feb 2021 17:22

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Contributors

Author: S. Ruta
Author: R. Chantrell
Author: O. Hovorka ORCID iD

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