Patient specific stress and rupture analysis of ascending thoracic aneurysms
Patient specific stress and rupture analysis of ascending thoracic aneurysms
An ascending thoracic aortic aneurysm (ATAA) is a serious medical condition which, more often than not, requires surgery. Aneurysm diameter is the primary clinical criterion for determining when surgical intervention is necessary but, biomechanical studies have suggested that the diameter criterion is insufficient. This manuscript presents a method for obtaining the patient specific wall stress distribution of the ATAA and the retrospective rupture risk for each patient. Five human ATAAs and the preoperative dynamic CT scans were obtained during elective surgeries to replace each patient's aneurysm with a synthetic graft. The material properties and rupture stress for each tissue sample were identified using bulge inflation tests. The dynamic CT scans were used to generate patient specific geometries for a finite element (FE) model of each patient
aneurysm rupture, ascending thoracic aortic aneurysm, finite element analysis, patient specific material properties, rupture risk, wall stress
1836-1843
Trabelsi, Olfa
bc5600a5-a70d-4661-b999-52b261a956ef
Davis, Frances M.
20f89066-bbac-42dc-908d-d89a747dc399
Rodriguez-Matas, Jose F.
71806eae-048d-46b5-868d-4e5554411b80
Duprey, Ambroise
ec5b5eac-34f2-4197-8be5-eaaa5575e1ff
Avril, Stephane
2a04eeed-db32-41eb-90fe-c21674b4496f
15 July 2015
Trabelsi, Olfa
bc5600a5-a70d-4661-b999-52b261a956ef
Davis, Frances M.
20f89066-bbac-42dc-908d-d89a747dc399
Rodriguez-Matas, Jose F.
71806eae-048d-46b5-868d-4e5554411b80
Duprey, Ambroise
ec5b5eac-34f2-4197-8be5-eaaa5575e1ff
Avril, Stephane
2a04eeed-db32-41eb-90fe-c21674b4496f
Trabelsi, Olfa, Davis, Frances M., Rodriguez-Matas, Jose F., Duprey, Ambroise and Avril, Stephane
(2015)
Patient specific stress and rupture analysis of ascending thoracic aneurysms.
Journal of Biomechanics, 48 (10), .
(doi:10.1016/j.jbiomech.2015.04.035).
(PMID:25979384)
Abstract
An ascending thoracic aortic aneurysm (ATAA) is a serious medical condition which, more often than not, requires surgery. Aneurysm diameter is the primary clinical criterion for determining when surgical intervention is necessary but, biomechanical studies have suggested that the diameter criterion is insufficient. This manuscript presents a method for obtaining the patient specific wall stress distribution of the ATAA and the retrospective rupture risk for each patient. Five human ATAAs and the preoperative dynamic CT scans were obtained during elective surgeries to replace each patient's aneurysm with a synthetic graft. The material properties and rupture stress for each tissue sample were identified using bulge inflation tests. The dynamic CT scans were used to generate patient specific geometries for a finite element (FE) model of each patient
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Accepted/In Press date: April 2015
e-pub ahead of print date: 2 May 2015
Published date: 15 July 2015
Keywords:
aneurysm rupture, ascending thoracic aortic aneurysm, finite element analysis, patient specific material properties, rupture risk, wall stress
Organisations:
Engineering Science Unit
Identifiers
Local EPrints ID: 382230
URI: http://eprints.soton.ac.uk/id/eprint/382230
ISSN: 0021-9290
PURE UUID: c009a72a-ff7d-414a-b3e0-70486d0e222a
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Date deposited: 27 Oct 2015 13:27
Last modified: 14 Mar 2024 21:26
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Contributors
Author:
Olfa Trabelsi
Author:
Frances M. Davis
Author:
Jose F. Rodriguez-Matas
Author:
Ambroise Duprey
Author:
Stephane Avril
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