Should the augmentation index be normalized to heart rate?
Should the augmentation index be normalized to heart rate?
Pulse wave analysis(PWA) is widely used to investigate systemic arterial stiffness. The augmentation index(AIx), the primary outcome derived from PWA, is influenced by the mean arterial pressure(MAP), age, gender and heart rate(HR). Gender- and age-specific reference values have been devised, and it is recommended that the MAP be used as a statistical covariate. The AIx is also commonly statistically adjusted to a HR of 75 b·min(-1); however, this approach may be physiologically and statistically inappropriate. First, there appears to be an important physiological chronic interaction between HR and arterial stiffness. Second, the method used to correct to HR assumes that the relationship with AIx is uniform across populations. A more appropriate practice may be to include HR as an independent predictor or covariate; this approach is particularly recommended for longitudinal studies, in which changes in HR may help to explain changes in arterial stiffness.
11-16
Stoner, Lee
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Faulkner, James
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Lowe, Andrew
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Lambrick, Danielle M.
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Young, Joanna M.
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Love, Richard
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Rowlands, David S.
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19 November 2013
Stoner, Lee
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Faulkner, James
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Lowe, Andrew
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Lambrick, Danielle M.
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Young, Joanna M.
fba26eb3-7735-4002-8d03-ff59fd586f86
Love, Richard
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Rowlands, David S.
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Stoner, Lee, Faulkner, James, Lowe, Andrew, Lambrick, Danielle M., Young, Joanna M., Love, Richard and Rowlands, David S.
(2013)
Should the augmentation index be normalized to heart rate?
Journal of Atherosclerosis and Thrombosis, 21 (1), .
(doi:10.5551/jat.20008).
Abstract
Pulse wave analysis(PWA) is widely used to investigate systemic arterial stiffness. The augmentation index(AIx), the primary outcome derived from PWA, is influenced by the mean arterial pressure(MAP), age, gender and heart rate(HR). Gender- and age-specific reference values have been devised, and it is recommended that the MAP be used as a statistical covariate. The AIx is also commonly statistically adjusted to a HR of 75 b·min(-1); however, this approach may be physiologically and statistically inappropriate. First, there appears to be an important physiological chronic interaction between HR and arterial stiffness. Second, the method used to correct to HR assumes that the relationship with AIx is uniform across populations. A more appropriate practice may be to include HR as an independent predictor or covariate; this approach is particularly recommended for longitudinal studies, in which changes in HR may help to explain changes in arterial stiffness.
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Should the augmentation index be normalized to heart rate?
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Accepted/In Press date: 18 September 2013
Published date: 19 November 2013
Organisations:
Faculty of Health Sciences
Identifiers
Local EPrints ID: 382270
URI: http://eprints.soton.ac.uk/id/eprint/382270
ISSN: 1340-3478
PURE UUID: cbee4b94-aa3e-49c8-b650-5f8d519202d8
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Date deposited: 01 Oct 2015 13:01
Last modified: 15 Mar 2024 03:51
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Contributors
Author:
Lee Stoner
Author:
James Faulkner
Author:
Andrew Lowe
Author:
Joanna M. Young
Author:
Richard Love
Author:
David S. Rowlands
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