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Towards laser driven table-top coherent diffractive X-ray microscopy of cultured hippocampal neurons

Towards laser driven table-top coherent diffractive X-ray microscopy of cultured hippocampal neurons
Towards laser driven table-top coherent diffractive X-ray microscopy of cultured hippocampal neurons
Neurodegenerative diseases such as Alzheimer’s disease have a huge impact on the world population; over 44 million people worldwide and 850,000 in the UK were recorded as living with dementia in 2013. There are numerous theories attempting to explain the cause of Alzheimer’s disease. Histology from the brains of people who had Alzheimer’s disease shows neurofibilliary tangles and amyloid plaques. Their role in the mechanism of disease is not yet completely understood but we envisage that novel imaging techniques may aid understanding. We present initial data collected using confocal fluorescence microscopy and hard X-ray scanning diffractive microscopy (ptychography) on cultured neuron samples plus high resolution large field of view imaging of test samples from a soft X-ray lab based high harmonic generation (HHG) source.
Baksh, Peter D.
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Odstrčil, Michal
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Parsons, Aaron
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Card, Rachel
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Boden, Stuart
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Brocklesby, William
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Frey, J.G.
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Baksh, Peter D.
578fea83-9a1c-4dd0-b3f6-66f5552f2344
Odstrčil, Michal
b297d3ec-ed42-4709-9f90-7af79d0644c7
Parsons, Aaron
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Card, Rachel
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Boden, Stuart
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Brocklesby, William
c53ca2f6-db65-4e19-ad00-eebeb2e6de67
Frey, J.G.
ba60c559-c4af-44f1-87e6-ce69819bf23f

Baksh, Peter D., Odstrčil, Michal, Parsons, Aaron, Card, Rachel, Boden, Stuart, Brocklesby, William and Frey, J.G. (2015) Towards laser driven table-top coherent diffractive X-ray microscopy of cultured hippocampal neurons. BIO-NANO-Photonics 2015, United Kingdom. 07 - 09 Sep 2015. 1 pp .

Record type: Conference or Workshop Item (Poster)

Abstract

Neurodegenerative diseases such as Alzheimer’s disease have a huge impact on the world population; over 44 million people worldwide and 850,000 in the UK were recorded as living with dementia in 2013. There are numerous theories attempting to explain the cause of Alzheimer’s disease. Histology from the brains of people who had Alzheimer’s disease shows neurofibilliary tangles and amyloid plaques. Their role in the mechanism of disease is not yet completely understood but we envisage that novel imaging techniques may aid understanding. We present initial data collected using confocal fluorescence microscopy and hard X-ray scanning diffractive microscopy (ptychography) on cultured neuron samples plus high resolution large field of view imaging of test samples from a soft X-ray lab based high harmonic generation (HHG) source.

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Published date: 7 September 2015
Venue - Dates: BIO-NANO-Photonics 2015, United Kingdom, 2015-09-07 - 2015-09-09
Organisations: Optoelectronics Research Centre, Chemistry, Electronics & Computer Science

Identifiers

Local EPrints ID: 382273
URI: https://eprints.soton.ac.uk/id/eprint/382273
PURE UUID: b1381a92-bf1c-4003-a220-20d1116f8bb7
ORCID for Stuart Boden: ORCID iD orcid.org/0000-0002-4232-1828
ORCID for William Brocklesby: ORCID iD orcid.org/0000-0002-2123-6712
ORCID for J.G. Frey: ORCID iD orcid.org/0000-0003-0842-4302

Catalogue record

Date deposited: 28 Oct 2015 13:59
Last modified: 15 Nov 2018 01:37

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Contributors

Author: Peter D. Baksh
Author: Michal Odstrčil
Author: Aaron Parsons
Author: Rachel Card
Author: Stuart Boden ORCID iD
Author: J.G. Frey ORCID iD

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