There's more to flow-mediated dilation than nitric oxide
There's more to flow-mediated dilation than nitric oxide
Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.
589-600
Stoner, Lee
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Erickson, Melissa Lynn
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Young, Joanna Mary
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Fryer, Simon
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Sabatier, Manning Joseph
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Faulkner, James
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Lambrick, Danielle Marie
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McCully, Kevin Kane
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10 May 2012
Stoner, Lee
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Erickson, Melissa Lynn
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Young, Joanna Mary
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Fryer, Simon
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Sabatier, Manning Joseph
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Faulkner, James
1bedc0f0-8fa4-4bf3-8e31-abd084b0c148
Lambrick, Danielle Marie
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McCully, Kevin Kane
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Stoner, Lee, Erickson, Melissa Lynn, Young, Joanna Mary, Fryer, Simon, Sabatier, Manning Joseph, Faulkner, James, Lambrick, Danielle Marie and McCully, Kevin Kane
(2012)
There's more to flow-mediated dilation than nitric oxide.
Journal of Atherosclerosis and Thrombosis, 19 (7), .
(PMID:22498768)
Abstract
Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.
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Published date: 10 May 2012
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 382315
URI: http://eprints.soton.ac.uk/id/eprint/382315
ISSN: 1340-3478
PURE UUID: 53fe02ab-57ff-4039-8d3a-e049b81e6f91
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Date deposited: 01 Oct 2015 15:30
Last modified: 23 Jul 2022 02:10
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Contributors
Author:
Lee Stoner
Author:
Melissa Lynn Erickson
Author:
Joanna Mary Young
Author:
Simon Fryer
Author:
Manning Joseph Sabatier
Author:
James Faulkner
Author:
Kevin Kane McCully
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