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There's more to flow-mediated dilation than nitric oxide

There's more to flow-mediated dilation than nitric oxide
There's more to flow-mediated dilation than nitric oxide
Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.
1340-3478
589-600
Stoner, Lee
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Erickson, Melissa Lynn
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Young, Joanna Mary
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Fryer, Simon
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Sabatier, Manning Joseph
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Faulkner, James
1bedc0f0-8fa4-4bf3-8e31-abd084b0c148
Lambrick, Danielle Marie
1deafa4b-acf3-4eff-83c9-f8274e47e993
McCully, Kevin Kane
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Stoner, Lee
0f9dd581-205f-490d-8879-7ba7cfa51450
Erickson, Melissa Lynn
9fea4d7f-b99d-4e35-8546-8de53252285d
Young, Joanna Mary
25b79c42-e052-4002-b333-0d5313036e6d
Fryer, Simon
c9e79f9f-d16b-44a9-926d-5e74f0af8934
Sabatier, Manning Joseph
98c28bf9-9bb4-4f0a-b869-b5ddb2c677b5
Faulkner, James
1bedc0f0-8fa4-4bf3-8e31-abd084b0c148
Lambrick, Danielle Marie
1deafa4b-acf3-4eff-83c9-f8274e47e993
McCully, Kevin Kane
12aa546f-b982-43dd-81ed-4b0d72137d99

Stoner, Lee, Erickson, Melissa Lynn, Young, Joanna Mary, Fryer, Simon, Sabatier, Manning Joseph, Faulkner, James, Lambrick, Danielle Marie and McCully, Kevin Kane (2012) There's more to flow-mediated dilation than nitric oxide. Journal of Atherosclerosis and Thrombosis, 19 (7), 589-600. (PMID:22498768)

Record type: Article

Abstract

Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.

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More information

Published date: 10 May 2012
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 382315
URI: http://eprints.soton.ac.uk/id/eprint/382315
ISSN: 1340-3478
PURE UUID: 53fe02ab-57ff-4039-8d3a-e049b81e6f91
ORCID for Danielle Marie Lambrick: ORCID iD orcid.org/0000-0002-0325-6015

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Date deposited: 01 Oct 2015 15:30
Last modified: 23 Jul 2022 02:10

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Contributors

Author: Lee Stoner
Author: Melissa Lynn Erickson
Author: Joanna Mary Young
Author: Simon Fryer
Author: Manning Joseph Sabatier
Author: James Faulkner
Author: Kevin Kane McCully

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