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Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population

Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population
Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population
Background: maternal obesity and hyperglycemia increase risk of obesity and diabetes in offspring later in life.

Objective: we examined the relation between gestational glycemia and prepregnancy body mass index (ppBMI) with offspring growth in an Asian mother-offspring cohort.

Design: pregnant mothers undertook a 75-g 2-h oral-glucose-tolerance test at 26–28 wk of gestation. In 937 singleton offspring, ?9 serial measurements of weight and length were obtained from birth until 36 mo of age.

Results: gestational fasting plasma glucose (FPG) was positively associated with birth weight (B: 0.17; 95% CI: 0.10, 0.24; P < 0.001) and birth BMI (B: 0.15; 95% CI: 0.06, 0.40; P = 0.001) but not at ?3 mo of age. In contrast, maternal ppBMI was positively associated with birth variables and conditional growth in weight and BMI in the first 36 mo of life. However, gestational FPG and prepregnancy obesity status interacted significantly for the association with offspring growth and overweight status in the first 36 mo of life (P-interaction < 0.01). In nonobese mothers, each unit increase in gestational FPG was associated with increased offspring weight (B: 0.08; 95% CI: 0.008, 0.16; P = 0.03) and BMI (B: 0.08; 95% CI: 0.003, 0.15; P = 0.04) as well as increased risk of overweight in the first 36 mo of life (OR: 1.36; 95% CI: 1.10, 1.68). However, in obese mothers, each unit increase in gestational FPG was associated with decreased offspring weight (B: ?0.01; 95% CI: ?0.02, ?0.003) and BMI (B: ?0.008; 95% CI: ?0.01, ?0.002) velocity (P < 0.01 for both) and decreased risk of overweight (OR: 0.59; 95% CI: 0.41, 0.86) in the first 36 mo of life.

Conclusions: prepregnancy adiposity was associated with offspring growth in early childhood. Although pooled analyses showed no demonstrable difference by 3 mo of age, there were contrasting and opposite associations of gestational glycemia with weight and BMI in the first 36 mo of life in offspring of nonobese and obese mothers separately. This study was registered at clinicaltrials.gov as NCT01174875
0002-9165
1-9
Aris, I.M.
ee15a46e-ead3-4b4a-a208-d39038a85480
Soh, S.E.
00a5ad13-4c5b-4fad-aaa9-d080d9aa63e8
Tint, M.T.
02d6a006-3b94-4328-b3c3-147a618d66c3
Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd
Rajadurai, V.S.
3b5f8939-462c-4200-9146-a600d4e2e62a
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Yap, F.
2c155211-be02-4dd5-9528-16a714e77452
Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Lee, Y.S.
829a41bb-945c-49cd-ad12-0f3d9c2782c6
Aris, I.M.
ee15a46e-ead3-4b4a-a208-d39038a85480
Soh, S.E.
00a5ad13-4c5b-4fad-aaa9-d080d9aa63e8
Tint, M.T.
02d6a006-3b94-4328-b3c3-147a618d66c3
Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd
Rajadurai, V.S.
3b5f8939-462c-4200-9146-a600d4e2e62a
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Yap, F.
2c155211-be02-4dd5-9528-16a714e77452
Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Lee, Y.S.
829a41bb-945c-49cd-ad12-0f3d9c2782c6

Aris, I.M., Soh, S.E., Tint, M.T., Saw, S.M., Rajadurai, V.S., Godfrey, K.M., Gluckman, P.D., Yap, F., Chong, Y.S. and Lee, Y.S. (2015) Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population. American Journal of Clinical Nutrition, 1-9. (PMID:26423388)

Record type: Article

Abstract

Background: maternal obesity and hyperglycemia increase risk of obesity and diabetes in offspring later in life.

Objective: we examined the relation between gestational glycemia and prepregnancy body mass index (ppBMI) with offspring growth in an Asian mother-offspring cohort.

Design: pregnant mothers undertook a 75-g 2-h oral-glucose-tolerance test at 26–28 wk of gestation. In 937 singleton offspring, ?9 serial measurements of weight and length were obtained from birth until 36 mo of age.

Results: gestational fasting plasma glucose (FPG) was positively associated with birth weight (B: 0.17; 95% CI: 0.10, 0.24; P < 0.001) and birth BMI (B: 0.15; 95% CI: 0.06, 0.40; P = 0.001) but not at ?3 mo of age. In contrast, maternal ppBMI was positively associated with birth variables and conditional growth in weight and BMI in the first 36 mo of life. However, gestational FPG and prepregnancy obesity status interacted significantly for the association with offspring growth and overweight status in the first 36 mo of life (P-interaction < 0.01). In nonobese mothers, each unit increase in gestational FPG was associated with increased offspring weight (B: 0.08; 95% CI: 0.008, 0.16; P = 0.03) and BMI (B: 0.08; 95% CI: 0.003, 0.15; P = 0.04) as well as increased risk of overweight in the first 36 mo of life (OR: 1.36; 95% CI: 1.10, 1.68). However, in obese mothers, each unit increase in gestational FPG was associated with decreased offspring weight (B: ?0.01; 95% CI: ?0.02, ?0.003) and BMI (B: ?0.008; 95% CI: ?0.01, ?0.002) velocity (P < 0.01 for both) and decreased risk of overweight (OR: 0.59; 95% CI: 0.41, 0.86) in the first 36 mo of life.

Conclusions: prepregnancy adiposity was associated with offspring growth in early childhood. Although pooled analyses showed no demonstrable difference by 3 mo of age, there were contrasting and opposite associations of gestational glycemia with weight and BMI in the first 36 mo of life in offspring of nonobese and obese mothers separately. This study was registered at clinicaltrials.gov as NCT01174875

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Published date: 30 September 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 382351
URI: https://eprints.soton.ac.uk/id/eprint/382351
ISSN: 0002-9165
PURE UUID: 3f3b9479-8200-4e0e-8c65-f3337c3f16b2
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 29 Oct 2015 11:05
Last modified: 06 Jun 2018 13:11

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Contributors

Author: I.M. Aris
Author: S.E. Soh
Author: M.T. Tint
Author: S.M. Saw
Author: V.S. Rajadurai
Author: K.M. Godfrey ORCID iD
Author: P.D. Gluckman
Author: F. Yap
Author: Y.S. Chong
Author: Y.S. Lee

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