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Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies

Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies
Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies
Cholangiocarcinoma (CCA) is a very aggressive neoplasm, whose incidence has steadily increased in the last decade. Despite its growing epidemiological impact, therapeutic chances with a curative intent are still limited to surgical resection and, in highly selected cases, to liver transplantation. Unfortunately, in most cases at the time of diagnosis, CCA has already metastasized to regional lymph nodes, thereby reducing the opportunities for curative treatment. Mechanisms governing CCA invasiveness are unclear. A critical element of CCA is the abundant “tumor reactive stroma”, which develops in close association with tumor growth. An abundant reactive stroma is present in a number of carcinomas characterized by strong invasiveness, namely gastric, colorectal and pancreatic cancers, as well as breast cancer. In tumor stroma, a variety of signals and mediators are reciprocally exchanged between stromal and cancer cells that, in turn acquire pro-invasive properties. These paracrine communications have started to be elucidated only recently, and may represent targets amenable of specific therapeutic intervention. In this review, we will highlight the cell types that compose the tumor reactive stroma in CCA and some of the molecular interactions possibly responsible for increased invasiveness of CCA. The possibility of dissecting, and likely exploiting, these interactions for potential new treatments will be also described
cholangiocarcinoma, tumor reactive stroma, cancer-associated fibroblast, tumor-associated macrophage, lymphangiogenesis
130-144
Cadamuro, Massimiliano
eee3861c-58b8-43a4-99d2-24f488b45eae
Morton, Stuart Duncan
7545cf7d-15a6-43cc-9949-41ece1749fef
Strazzabosco, Mario
18e0c674-2971-4029-8c9f-7770f14ea564
Fabris, Luca
7ab16fef-75b0-4131-a451-86fc97903b92
Cadamuro, Massimiliano
eee3861c-58b8-43a4-99d2-24f488b45eae
Morton, Stuart Duncan
7545cf7d-15a6-43cc-9949-41ece1749fef
Strazzabosco, Mario
18e0c674-2971-4029-8c9f-7770f14ea564
Fabris, Luca
7ab16fef-75b0-4131-a451-86fc97903b92

Cadamuro, Massimiliano, Morton, Stuart Duncan, Strazzabosco, Mario and Fabris, Luca (2013) Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies. Translational Gastrointestinal Cancer, 2 (3), 130-144.

Record type: Article

Abstract

Cholangiocarcinoma (CCA) is a very aggressive neoplasm, whose incidence has steadily increased in the last decade. Despite its growing epidemiological impact, therapeutic chances with a curative intent are still limited to surgical resection and, in highly selected cases, to liver transplantation. Unfortunately, in most cases at the time of diagnosis, CCA has already metastasized to regional lymph nodes, thereby reducing the opportunities for curative treatment. Mechanisms governing CCA invasiveness are unclear. A critical element of CCA is the abundant “tumor reactive stroma”, which develops in close association with tumor growth. An abundant reactive stroma is present in a number of carcinomas characterized by strong invasiveness, namely gastric, colorectal and pancreatic cancers, as well as breast cancer. In tumor stroma, a variety of signals and mediators are reciprocally exchanged between stromal and cancer cells that, in turn acquire pro-invasive properties. These paracrine communications have started to be elucidated only recently, and may represent targets amenable of specific therapeutic intervention. In this review, we will highlight the cell types that compose the tumor reactive stroma in CCA and some of the molecular interactions possibly responsible for increased invasiveness of CCA. The possibility of dissecting, and likely exploiting, these interactions for potential new treatments will be also described

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More information

Published date: 2013
Keywords: cholangiocarcinoma, tumor reactive stroma, cancer-associated fibroblast, tumor-associated macrophage, lymphangiogenesis
Organisations: Medical Education

Identifiers

Local EPrints ID: 382368
URI: https://eprints.soton.ac.uk/id/eprint/382368
PURE UUID: a7b1905c-cef5-4605-ba64-a25a509b7fdf
ORCID for Stuart Duncan Morton: ORCID iD orcid.org/0000-0002-5921-4869

Catalogue record

Date deposited: 29 Oct 2015 11:45
Last modified: 06 Jun 2018 12:20

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