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Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma

Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma
Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma
CCA cells express several mesenchymal markers, but do not transdifferentiate into CAFs. Instead, CCA cells recruit CAFs by secreting PDGF-D, which stimulates fibroblast migration through PDGFR? and Rho GTPase and JNK activation. Targeting tumor or stroma interactions with inhibitors of the PDGF-D pathway may offer a novel therapeutic approach
0270-9139
1042-1053
Cadamuro, Massimiliano
eee3861c-58b8-43a4-99d2-24f488b45eae
Nardo, Giorgia
4061e437-3c4f-442c-a21f-4a6b04dcd0e4
Indraccolo, Stefano
0d23f17a-6319-4215-99cc-1de6428de73c
Dall'olmo, Luigi
6115c805-1ac3-4308-a241-164db2726d38
Sambado, Luisa
b0171b6a-2017-4503-aee4-8607546e1b99
Moserle, Lidia
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Franceschet, Irene
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Colledan, Michele
5dcf11ee-4a62-4d94-af58-900e5425fcdd
Massani, Marco
32fad209-0241-4168-8b07-06d17808a2b8
Stecca, Tommaso
196ca669-5540-4216-883d-ed9b32ee5ac8
Bassi, Nicolò
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Morton, Stuart
7545cf7d-15a6-43cc-9949-41ece1749fef
Spirli, Carlo
a71a179c-0648-4d86-aad3-978470660acd
Fiorotto, Romina
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Fabris, Luca
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Strazzabosco, Mario
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Cadamuro, Massimiliano
eee3861c-58b8-43a4-99d2-24f488b45eae
Nardo, Giorgia
4061e437-3c4f-442c-a21f-4a6b04dcd0e4
Indraccolo, Stefano
0d23f17a-6319-4215-99cc-1de6428de73c
Dall'olmo, Luigi
6115c805-1ac3-4308-a241-164db2726d38
Sambado, Luisa
b0171b6a-2017-4503-aee4-8607546e1b99
Moserle, Lidia
7d6213ce-4c45-4d83-8f41-e5f5067ba6de
Franceschet, Irene
79960b74-7697-4a00-9a62-0819b49723b4
Colledan, Michele
5dcf11ee-4a62-4d94-af58-900e5425fcdd
Massani, Marco
32fad209-0241-4168-8b07-06d17808a2b8
Stecca, Tommaso
196ca669-5540-4216-883d-ed9b32ee5ac8
Bassi, Nicolò
0b829168-b99e-4258-8cf6-9f7136cc9d58
Morton, Stuart
7545cf7d-15a6-43cc-9949-41ece1749fef
Spirli, Carlo
a71a179c-0648-4d86-aad3-978470660acd
Fiorotto, Romina
a3fb15a8-d882-4406-8d0e-6eeb95c98059
Fabris, Luca
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Strazzabosco, Mario
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Cadamuro, Massimiliano, Nardo, Giorgia, Indraccolo, Stefano, Dall'olmo, Luigi, Sambado, Luisa, Moserle, Lidia, Franceschet, Irene, Colledan, Michele, Massani, Marco, Stecca, Tommaso, Bassi, Nicolò, Morton, Stuart, Spirli, Carlo, Fiorotto, Romina, Fabris, Luca and Strazzabosco, Mario (2013) Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma. Hepatology, 58 (3), 1042-1053. (doi:10.1002/hep.26384). (PMID:23696149)

Record type: Article

Abstract

CCA cells express several mesenchymal markers, but do not transdifferentiate into CAFs. Instead, CCA cells recruit CAFs by secreting PDGF-D, which stimulates fibroblast migration through PDGFR? and Rho GTPase and JNK activation. Targeting tumor or stroma interactions with inhibitors of the PDGF-D pathway may offer a novel therapeutic approach

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More information

Published date: September 2013
Organisations: Medical Education

Identifiers

Local EPrints ID: 382371
URI: https://eprints.soton.ac.uk/id/eprint/382371
ISSN: 0270-9139
PURE UUID: df72eba6-17f8-46b7-9c00-5ff1b0df5c6d
ORCID for Stuart Morton: ORCID iD orcid.org/0000-0002-5921-4869

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Date deposited: 29 Oct 2015 11:56
Last modified: 20 Jul 2019 00:33

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Contributors

Author: Massimiliano Cadamuro
Author: Giorgia Nardo
Author: Stefano Indraccolo
Author: Luigi Dall'olmo
Author: Luisa Sambado
Author: Lidia Moserle
Author: Irene Franceschet
Author: Michele Colledan
Author: Marco Massani
Author: Tommaso Stecca
Author: Nicolò Bassi
Author: Stuart Morton ORCID iD
Author: Carlo Spirli
Author: Romina Fiorotto
Author: Luca Fabris
Author: Mario Strazzabosco

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