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Mammographic surveillance in women aged 35–39 at enhanced familial risk of breast cancer (FH02)

Mammographic surveillance in women aged 35–39 at enhanced familial risk of breast cancer (FH02)
Mammographic surveillance in women aged 35–39 at enhanced familial risk of breast cancer (FH02)
Although there have been encouraging recent studies showing a potential benefit from annual mammography in women aged 40-49 years of age with an elevated breast cancer risk due to family history there is little evidence of efficacy in women aged <40 years of age. A prospective study (FH02) has been developed to assess the efficacy of mammography screening in women aged 35-39 years of age with a lifetime breast cancer risk of ? 17 % who are not receiving MRI screening. Retrospective analyses from five centres with robust recall systems identified 47 breast cancers (n = 12 in situ) with an interval cancer rate of 15/47 (32%). Invasive tumour size, lymph node status and current vital status were all significantly better than in two control groups of unscreened women (including those with a family history) recruited to the POSH study. Further evaluation of the prospective arm of FH02 is required to assess the potential added value of digital mammography and the cancer incidence rates in moderate and high risk women in order to inform cost effectiveness analyses
breast cancer, screening, mammography, MRI, BRCA1, BRCA2, high-risk
1389-9600
13-21
Evans, D.G.
b58c99fc-4da0-4d7e-b140-f22307befe5e
Thomas, S.
0f83004b-179e-4b71-8374-25345d0e9dad
Caunt, J.
e3070329-9b1b-4317-9981-40a738d28cf6
Roberts, L.
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Howell, A.
d66cb75b-55f5-4b55-bdff-79a7536aec10
Wilson, M.
eb86ea3a-b4c5-4328-85bf-b20cc96c6c63
Fox, R.
19bb9dd3-8a14-4c7b-b30b-9e7f81f3545e
Sibbering, D.M.
b7404da1-4d0c-4a9a-90d1-1fac5dd8b995
Moss, S.
9720f4c7-514f-4248-a6a3-59da8db73c36
Wallis, M.G.
4db3417d-ce01-4bcb-ace3-e680ab8d0f47
Eccles, D.M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Duffy, S.
816e056e-3d66-484a-a789-2054abef0414
Evans, D.G.
b58c99fc-4da0-4d7e-b140-f22307befe5e
Thomas, S.
0f83004b-179e-4b71-8374-25345d0e9dad
Caunt, J.
e3070329-9b1b-4317-9981-40a738d28cf6
Roberts, L.
53dfbe97-36ff-4b09-add2-51dc768eddff
Howell, A.
d66cb75b-55f5-4b55-bdff-79a7536aec10
Wilson, M.
eb86ea3a-b4c5-4328-85bf-b20cc96c6c63
Fox, R.
19bb9dd3-8a14-4c7b-b30b-9e7f81f3545e
Sibbering, D.M.
b7404da1-4d0c-4a9a-90d1-1fac5dd8b995
Moss, S.
9720f4c7-514f-4248-a6a3-59da8db73c36
Wallis, M.G.
4db3417d-ce01-4bcb-ace3-e680ab8d0f47
Eccles, D.M.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Duffy, S.
816e056e-3d66-484a-a789-2054abef0414

Evans, D.G., Thomas, S. and Caunt, J. et al. (2014) Mammographic surveillance in women aged 35–39 at enhanced familial risk of breast cancer (FH02). Familial Cancer, 13 (1), 13-21. (doi:10.1007/s10689-013-9661-8). (PMID:23733252)

Record type: Article

Abstract

Although there have been encouraging recent studies showing a potential benefit from annual mammography in women aged 40-49 years of age with an elevated breast cancer risk due to family history there is little evidence of efficacy in women aged <40 years of age. A prospective study (FH02) has been developed to assess the efficacy of mammography screening in women aged 35-39 years of age with a lifetime breast cancer risk of ? 17 % who are not receiving MRI screening. Retrospective analyses from five centres with robust recall systems identified 47 breast cancers (n = 12 in situ) with an interval cancer rate of 15/47 (32%). Invasive tumour size, lymph node status and current vital status were all significantly better than in two control groups of unscreened women (including those with a family history) recruited to the POSH study. Further evaluation of the prospective arm of FH02 is required to assess the potential added value of digital mammography and the cancer incidence rates in moderate and high risk women in order to inform cost effectiveness analyses

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e-pub ahead of print date: 4 June 2013
Published date: March 2014
Keywords: breast cancer, screening, mammography, MRI, BRCA1, BRCA2, high-risk
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 382766
URI: http://eprints.soton.ac.uk/id/eprint/382766
ISSN: 1389-9600
PURE UUID: 9d2b758b-2fad-44e4-a41a-412a3f3439e8
ORCID for D.M. Eccles: ORCID iD orcid.org/0000-0002-9935-3169

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Date deposited: 12 Oct 2015 10:32
Last modified: 15 Mar 2024 02:40

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Contributors

Author: D.G. Evans
Author: S. Thomas
Author: J. Caunt
Author: L. Roberts
Author: A. Howell
Author: M. Wilson
Author: R. Fox
Author: D.M. Sibbering
Author: S. Moss
Author: M.G. Wallis
Author: D.M. Eccles ORCID iD
Author: S. Duffy

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