The role of acoustofluidics in targeted drug delivery
The role of acoustofluidics in targeted drug delivery
With the fast development of acoustic systems in clinical and therapeutic applications, acoustically driven microbubbles have gained a prominent role as powerful tools to carry, transfer, direct, and target drug molecules in cells, tissues, and tumors in the expanding fields of targeted drug delivery and gene therapy. The aim of the present study is to establish a biocompatible acoustic microfluidic system and to demonstrate the generation of an acoustic field and its effects on microbubbles and biological cells in the microfluidic system. The acoustic field creates non-linear oscillations of the microbubble-clusters, which results in generation of shear stress on cells in such microsystems. This effectively helps in delivering extracellular probes in living cells by sonoporation. The sonoporation is investigated under the combined effects of acoustic stress and hydrodynamic stress during targeted drug and gene delivery.
052609-[17pp]
Bose, Nilanjana
14ae3eff-8033-4963-846b-00dafed837a9
Zhang, Xunli
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Maiti, Tapas K.
74dc5cab-ab60-46db-b9e1-007bb192b0c5
Chakrab, Suman
cd4ef948-86d8-485f-9df4-c92ff15c4617
September 2015
Bose, Nilanjana
14ae3eff-8033-4963-846b-00dafed837a9
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Maiti, Tapas K.
74dc5cab-ab60-46db-b9e1-007bb192b0c5
Chakrab, Suman
cd4ef948-86d8-485f-9df4-c92ff15c4617
Bose, Nilanjana, Zhang, Xunli, Maiti, Tapas K. and Chakrab, Suman
(2015)
The role of acoustofluidics in targeted drug delivery.
Biomicrofluidics, 9 (5), .
(doi:10.1063/1.4928947).
(PMID:26339329)
Abstract
With the fast development of acoustic systems in clinical and therapeutic applications, acoustically driven microbubbles have gained a prominent role as powerful tools to carry, transfer, direct, and target drug molecules in cells, tissues, and tumors in the expanding fields of targeted drug delivery and gene therapy. The aim of the present study is to establish a biocompatible acoustic microfluidic system and to demonstrate the generation of an acoustic field and its effects on microbubbles and biological cells in the microfluidic system. The acoustic field creates non-linear oscillations of the microbubble-clusters, which results in generation of shear stress on cells in such microsystems. This effectively helps in delivering extracellular probes in living cells by sonoporation. The sonoporation is investigated under the combined effects of acoustic stress and hydrodynamic stress during targeted drug and gene delivery.
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Accepted/In Press date: 8 August 2015
e-pub ahead of print date: 20 August 2015
Published date: September 2015
Organisations:
Bioengineering Group
Identifiers
Local EPrints ID: 382919
URI: http://eprints.soton.ac.uk/id/eprint/382919
ISSN: 1932-1058
PURE UUID: 242a120a-4638-404b-9be8-190ae126a3d5
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Date deposited: 04 Nov 2015 12:23
Last modified: 15 Mar 2024 03:29
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Contributors
Author:
Nilanjana Bose
Author:
Tapas K. Maiti
Author:
Suman Chakrab
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