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Impact of antidepressant drugs on sexual function and satisfaction

Impact of antidepressant drugs on sexual function and satisfaction
Impact of antidepressant drugs on sexual function and satisfaction
Pleasurable sexual activity is important in many human relationships and can provide a sense of physical, emotional and social well-being. Depressive symptoms and depressive illness are associated with impairments in sexual function and sexual dissatisfaction in untreated and treated patients. Most currently available antidepressant drugs are associated with development or worsening of sexual dysfunction in a substantial proportion of patients. Sexual difficulties during antidepressant treatment often resolve as depression lifts, but can persist over long periods, reducing self-esteem and affecting mood and relationships adversely. Sexual difficulties during antidepressant treatment typically have many possible causes but the incidence and nature of dysfunction varies between drugs. Many interventions can be considered when managing sexual dysfunction associated with antidepressants but no approach is ‘ideal’. Because treatment-emergent sexual difficulties are less frequent with certain drugs, presumably related to differences in pharmacological properties, and since current interventions are suboptimal, a lower incidence of sexual dysfunction is a relevant tolerability target when developing novel antidepressants
1172-7047
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Manson, Christopher
973e102a-d89d-4bdc-95e8-399fe4b4fc16
Nowak, Magdalena
0ab13ac2-e943-4715-af60-8f62ae91404e
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Manson, Christopher
973e102a-d89d-4bdc-95e8-399fe4b4fc16
Nowak, Magdalena
0ab13ac2-e943-4715-af60-8f62ae91404e

Baldwin, David, Manson, Christopher and Nowak, Magdalena (2015) Impact of antidepressant drugs on sexual function and satisfaction. CNS drugs. (doi:10.1007/s40263-015-0294-3).

Record type: Article

Abstract

Pleasurable sexual activity is important in many human relationships and can provide a sense of physical, emotional and social well-being. Depressive symptoms and depressive illness are associated with impairments in sexual function and sexual dissatisfaction in untreated and treated patients. Most currently available antidepressant drugs are associated with development or worsening of sexual dysfunction in a substantial proportion of patients. Sexual difficulties during antidepressant treatment often resolve as depression lifts, but can persist over long periods, reducing self-esteem and affecting mood and relationships adversely. Sexual difficulties during antidepressant treatment typically have many possible causes but the incidence and nature of dysfunction varies between drugs. Many interventions can be considered when managing sexual dysfunction associated with antidepressants but no approach is ‘ideal’. Because treatment-emergent sexual difficulties are less frequent with certain drugs, presumably related to differences in pharmacological properties, and since current interventions are suboptimal, a lower incidence of sexual dysfunction is a relevant tolerability target when developing novel antidepressants

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More information

Accepted/In Press date: 14 October 2015
e-pub ahead of print date: 30 October 2015
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 382988
URI: https://eprints.soton.ac.uk/id/eprint/382988
ISSN: 1172-7047
PURE UUID: e7a2aa04-ad67-4418-a0de-611c16d854af

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Date deposited: 09 Nov 2015 09:45
Last modified: 17 Jul 2017 20:17

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