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Comment on : Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer

Comment on : Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer
Comment on : Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer
As we begin to better understand the influence of specific genetic mutations on prostate carcinogenesis, it is critically important to define the relationship of such mutations with disease outcome. To date, reports on the relationship between BRCA mutations and prostate cancer risk and outcome have been inconsistent, and at times contradictory. In this study the authors report a substantially worsened outcome for men with vs without germline BRCA1/2 mutations. Importantly these men presented with not only more advanced stage, but also higher Gleason score, suggesting phenotype rather than delay in diagnosis. In the setting of a recent report of a man undergoing prophylactic prostatectomy due to BRCA mutation this article offers guidance to the many men with known BRCA mutations who are unclear about the role of early intervention
1527-7755
2093-2094
Taneja, S.S.
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Castro, E.
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Goh, C.
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Olmos, D.
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Saunders, E.
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Leongamornlert, D.
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Tymrakiewicz, M.
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Mahmud, N.
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Dadaev, T.
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Govindasami, K.
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Guy, M.
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Sawyer, E.
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Wilkinson, R.
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Ardern-Jones, A.
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Ellis, S.
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Frost, D.
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Peock, S.
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Evans, D.G.
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Tischkowitz, M.
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Cole, T.
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Davidson, R.
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Eccles, D.
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Brewer, C.
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Douglas, F.
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Porteous, M.E.
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Donaldson, A.
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Dorkins, H.
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Hodgson, S.
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Cook, J.
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Kennedy, M.J.
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Murray, A.
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Side, L.E.
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Eason, J.
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Antoniou, A.C.
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Easton, D.F.
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Kote-Jarai, Z.
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Eeles, R.
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Taneja, S.S.
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Castro, E.
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Goh, C.
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Olmos, D.
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Saunders, E.
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Leongamornlert, D.
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Tymrakiewicz, M.
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Mahmud, N.
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Dadaev, T.
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Sawyer, E.
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Wilkinson, R.
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Ardern-Jones, A.
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Ellis, S.
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Frost, D.
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Peock, S.
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Evans, D.G.
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Tischkowitz, M.
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Cole, T.
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Davidson, R.
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Eccles, D.
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Douglas, F.
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Donaldson, A.
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Dorkins, H.
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Izatt, L.
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Hodgson, S.
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Cook, J.
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Kennedy, M.J.
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Murray, A.
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Side, L.E.
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Eason, J.
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Antoniou, A.C.
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Easton, D.F.
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Kote-Jarai, Z.
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Eeles, R.
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Taneja, S.S., Castro, E. and Goh, C. et al. (2013) Comment on : Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. Journal of Clinical Oncology, 190 (6), 2093-2094. (doi:10.1016/j.juro.2013.08.101). (PMID:24209519)

Record type: Article

Abstract

As we begin to better understand the influence of specific genetic mutations on prostate carcinogenesis, it is critically important to define the relationship of such mutations with disease outcome. To date, reports on the relationship between BRCA mutations and prostate cancer risk and outcome have been inconsistent, and at times contradictory. In this study the authors report a substantially worsened outcome for men with vs without germline BRCA1/2 mutations. Importantly these men presented with not only more advanced stage, but also higher Gleason score, suggesting phenotype rather than delay in diagnosis. In the setting of a recent report of a man undergoing prophylactic prostatectomy due to BRCA mutation this article offers guidance to the many men with known BRCA mutations who are unclear about the role of early intervention

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More information

e-pub ahead of print date: 6 September 2013
Published date: December 2013
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 383025
URI: http://eprints.soton.ac.uk/id/eprint/383025
DOI: doi:10.1016/j.juro.2013.08.101
ISSN: 1527-7755
PURE UUID: 8b2d2bf5-0c7d-4ffa-bd84-f9dba9416792
ORCID for D. Eccles: ORCID iD orcid.org/0000-0002-9935-3169

Catalogue record

Date deposited: 19 Oct 2015 08:32
Last modified: 15 Mar 2024 02:40

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Contributors

Author: S.S. Taneja
Author: E. Castro
Author: C. Goh
Author: D. Olmos
Author: E. Saunders
Author: D. Leongamornlert
Author: M. Tymrakiewicz
Author: N. Mahmud
Author: T. Dadaev
Author: K. Govindasami
Author: M. Guy
Author: E. Sawyer
Author: R. Wilkinson
Author: A. Ardern-Jones
Author: S. Ellis
Author: D. Frost
Author: S. Peock
Author: D.G. Evans
Author: M. Tischkowitz
Author: T. Cole
Author: R. Davidson
Author: D. Eccles ORCID iD
Author: C. Brewer
Author: F. Douglas
Author: M.E. Porteous
Author: A. Donaldson
Author: H. Dorkins
Author: L. Izatt
Author: S. Hodgson
Author: J. Cook
Author: M.J. Kennedy
Author: A. Murray
Author: L.E. Side
Author: J. Eason
Author: A.C. Antoniou
Author: D.F. Easton
Author: Z. Kote-Jarai
Author: R. Eeles

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