The University of Southampton
University of Southampton Institutional Repository

Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR)?=?1.03, 95% CI 1.00-1.06, p?=?0.023). There was evidence for heterogeneity in the ORs among studies (I(2)?=?49.3%; p?=?<0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR?=?0.89, 95%CI 0.80-1.00, p?=?0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
1932-6203
e35706-[10pp]
Prokunina-Olsson, Ludmila
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Kirchhoff, Tomas
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Antoniou, Antonis C.
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McGuffog, Lesley
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Flyger, Henrik
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Hillemanns, Peter
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Van ‘t Veer, Laura J.
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Renwick, Anthony
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Southey, Melissa C.
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Hopper, John L.
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Hammet, Fleur
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van Asperen, Christi J.
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Lindblom, Annika
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Milne, Roger L.
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Arias, José Ignacio
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Benítez, Javier
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Severi, Gianluca
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Giles, Graham G.
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Beesley, Jonathan
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Chen, Xiaoqing
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Healey, Sue
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Caligo, Maria A.
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Godwin, Andrew K.
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Nevanlinna, Heli
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Heikkinen, Tuomas
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Fredericksen, Zachary
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Lindor, Noralane
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Domchek, Susan M.
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Loman, Niklas
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Karlsson, Per
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von Wachenfeldt, Anna
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Hogervorst, Frans B. L.
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Verheus, Martijn
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Johnson, Nichola
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Fletcher, Olivia
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Gibson, Lorna
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Peto, Julian
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Turnbull, Clare
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Van Dorpe, Thijs
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Hatse, Sigrid
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Lambrechts, Diether
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Andrulis, Irene L.
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Bogdanova, Natalia
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Antonenkova, Natalia
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Rogov, Juri I.
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Prokofieva, Daria
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Bermisheva, Marina
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Khusnutdinova, Elza
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van Asperen, Christi J.
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Hooning, Maartje J.
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Devilee, Peter
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Margolin, Sara
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Lindblom, Annika
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Milne, Roger L.
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Arias, José Ignacio
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Zamora, M. Pilar
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Benítez, Javier
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Severi, Gianluca
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Baglietto, Laura
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Giles, Graham G.
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Spurdle, Amanda B.
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Beesley, Jonathan
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Chen, Xiaoqing
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Holland, Helene
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Healey, Sue
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Wang-Gohrke, Shan
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Chang-Claude, Jenny
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Mannermaa, Arto
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Kosma, Veli-Matti
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Kataja, Vesa
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Agnarsson, Bjarni A.
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Caligo, Maria A.
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Godwin, Andrew K.
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Nevanlinna, Heli
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Heikkinen, Tuomas
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Lindor, Noralane
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Domchek, Susan M.
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Loman, Niklas
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Karlsson, Per
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Askmalm, Marie Stenmark
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Melin, Beatrice
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von Wachenfeldt, Anna
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Hogervorst, Frans B. L.
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Verheus, Martijn
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Rookus, Matti A.
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Seynaeve, Caroline
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Oldenburg, Rogier A.
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Ligtenberg, Marjolijn J.
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Ausems, Margreet G.E.M.
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Aalfs, Cora M.
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Gille, Hans J.P.
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Wijnen, Juul T.
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Gómez García, Encarna B.
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Davidson, Rosemarie
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Chu, Carol
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Eccles, Diana
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Ong, Kai-Ren
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Cook, Jackie
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Hodgson, Shirley
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Gold, Bert
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Prokunina-Olsson, Ludmila, Kirchhoff, Tomas and Gaudet, Mia M. et al. (2012) Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2. PLoS ONE, 7 (6), e35706-[10pp]. (PMID:22768030)

Record type: Article

Abstract

Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR)?=?1.03, 95% CI 1.00-1.06, p?=?0.023). There was evidence for heterogeneity in the ORs among studies (I(2)?=?49.3%; p?=?<0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR?=?0.89, 95%CI 0.80-1.00, p?=?0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.

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Accepted/In Press date: 19 March 2012
e-pub ahead of print date: 29 June 2012
Published date: 2012
Organisations: Cancer Sciences

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Local EPrints ID: 383060
URI: https://eprints.soton.ac.uk/id/eprint/383060
ISSN: 1932-6203
PURE UUID: ae9995b3-23d7-4c39-8891-9a56f7180acb

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Date deposited: 20 Oct 2015 10:37
Last modified: 08 Nov 2017 01:55

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Contributors

Author: Ludmila Prokunina-Olsson
Author: Tomas Kirchhoff
Author: Mia M. Gaudet
Author: Antonis C. Antoniou
Author: Lesley McGuffog
Author: Manjeet K. Humphreys
Author: Alison M. Dunning
Author: Stig E. Bojesen
Author: Børge G. Nordestgaard
Author: Henrik Flyger
Author: Daehee Kang
Author: Keun-Young Yoo
Author: Dong-Young Noh
Author: Sei-Hyun Ahn
Author: Thilo Dork
Author: Peter Schürmann
Author: Johann H. Karstens
Author: Peter Hillemanns
Author: Fergus J. Couch
Author: Janet Olson
Author: Celine Vachon
Author: Xianshu Wang
Author: Angela Cox
Author: Ian Brock
Author: Graeme Elliott
Author: Malcolm W.R. Reed
Author: Barbara Burwinkel
Author: Alfons Meindl
Author: Hiltrud Brauch
Author: Ute Hamann
Author: Yon-Dschun Ko
Author: Annegien Broeks
Author: Marjanka K. Schmidt
Author: Laura J. Van ‘t Veer
Author: Linde M. Braaf
Author: Nichola Johnson
Author: Olivia Fletcher
Author: Lorna Gibson
Author: Julian Peto
Author: Clare Turnbull
Author: Sheila Seal
Author: Anthony Renwick
Author: Nazneen Rahman
Author: Pei-Ei Wu
Author: Jyh-Cherng Yu
Author: Chia-Ni Hsiung
Author: Chen-Yang Shen
Author: Melissa C. Southey
Author: John L. Hopper
Author: Fleur Hammet
Author: Thijs Van Dorpe
Author: Anne-Sophie Dieudonne
Author: Sigrid Hatse
Author: Diether Lambrechts
Author: Irene L. Andrulis
Author: Natalia Bogdanova
Author: Natalia Antonenkova
Author: Juri I. Rogov
Author: Daria Prokofieva
Author: Marina Bermisheva
Author: Elza Khusnutdinova
Author: Christi J. van Asperen
Author: Robert A.E.M. Tollenaar
Author: Maartje J. Hooning
Author: Peter Devilee
Author: Sara Margolin
Author: Annika Lindblom
Author: Roger L. Milne
Author: José Ignacio Arias
Author: M. Pilar Zamora
Author: Javier Benítez
Author: Gianluca Severi
Author: Laura Baglietto
Author: Graham G. Giles
Author: AOCS Study Group
Author: Amanda B. Spurdle
Author: Jonathan Beesley
Author: Xiaoqing Chen
Author: Helene Holland
Author: Sue Healey
Author: Shan Wang-Gohrke
Author: Jenny Chang-Claude
Author: Arto Mannermaa
Author: Veli-Matti Kosma
Author: Jaana Kauppinen
Author: Vesa Kataja
Author: Bjarni A. Agnarsson
Author: Maria A. Caligo
Author: Andrew K. Godwin
Author: Heli Nevanlinna
Author: Tuomas Heikkinen
Author: Zachary Fredericksen
Author: Noralane Lindor
Author: Katherine L. Nathanson
Author: Susan M. Domchek
Author: Niklas Loman
Author: Per Karlsson
Author: Marie Stenmark Askmalm
Author: Beatrice Melin
Author: Anna von Wachenfeldt
Author: Frans B. L. Hogervorst
Author: Martijn Verheus
Author: Matti A. Rookus
Author: Caroline Seynaeve
Author: Rogier A. Oldenburg
Author: Marjolijn J. Ligtenberg
Author: Margreet G.E.M. Ausems
Author: Cora M. Aalfs
Author: Hans J.P. Gille
Author: Juul T. Wijnen
Author: Encarna B. Gómez García
Author: Susan Peock
Author: Margaret Cook
Author: Clare T. Oliver
Author: Debra Frost
Author: Craig Luccarini
Author: Gabriella Pichert
Author: Rosemarie Davidson
Author: Carol Chu
Author: Diana Eccles
Author: Kai-Ren Ong
Author: Jackie Cook
Author: Fiona Douglas
Author: Shirley Hodgson
Author: D. Gareth Evans
Author: Rosalind Eeles
Author: Bert Gold
Author: Paul D.P. Pharoah
Author: Kenneth Offit
Author: Georgia Chenevix-Trench
Author: Douglas F. Easton

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