Platelet microvesicles (microparticles) in cardiac surgery
Platelet microvesicles (microparticles) in cardiac surgery
SIGNIFICANT POSTOPERATIVE BLEEDING is a common risk of cardiac surgery, with approximately 3.5% of patients requiring surgical re-exploration.1 Re-exploration is associated with adverse outcomes, including infections, ischemia, and increased 30-day mortality.2 Similar adverse outcomes are related to erythrocyte transfusions associated with cardiac surgery,3 in addition to the immunologic and administrative hazards of transfusion.4 These risks are important because the majority of patients undergoing cardiac surgery receive a blood transfusion despite the lack of evidence to support liberal transfusion strategies.5 The frequency and significance of bleeding after cardiac surgery warrant investigation of the hematologic changes throughout the procedure. This review focuses on the (patho)physiology of platelet-derived microvesicles in the setting of cardiovascular surgery, a developing area in the understanding of the control of coagulation.
222-228
Tempo, Jake
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Englyst, Nicola A.
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Holloway, Judith A.
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Smith, David C.
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January 2016
Tempo, Jake
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Englyst, Nicola A.
f84399af-7265-4224-b556-102c3aa272b0
Holloway, Judith A.
f22f45f3-6fc8-4a4c-bc6c-24add507037c
Smith, David C.
cc2ef49e-7c4a-4476-9ed0-18ec22976bf1
Tempo, Jake, Englyst, Nicola A., Holloway, Judith A. and Smith, David C.
(2016)
Platelet microvesicles (microparticles) in cardiac surgery.
Journal of Cardiothoracic and Vascular Anesthesia, 30 (1), .
(doi:10.1053/j.jvca.2015.08.001).
Abstract
SIGNIFICANT POSTOPERATIVE BLEEDING is a common risk of cardiac surgery, with approximately 3.5% of patients requiring surgical re-exploration.1 Re-exploration is associated with adverse outcomes, including infections, ischemia, and increased 30-day mortality.2 Similar adverse outcomes are related to erythrocyte transfusions associated with cardiac surgery,3 in addition to the immunologic and administrative hazards of transfusion.4 These risks are important because the majority of patients undergoing cardiac surgery receive a blood transfusion despite the lack of evidence to support liberal transfusion strategies.5 The frequency and significance of bleeding after cardiac surgery warrant investigation of the hematologic changes throughout the procedure. This review focuses on the (patho)physiology of platelet-derived microvesicles in the setting of cardiovascular surgery, a developing area in the understanding of the control of coagulation.
Text
Accepted Manuscripts_Tempo_Platelets.pdf
- Accepted Manuscript
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e-pub ahead of print date: 10 August 2015
Published date: January 2016
Organisations:
Faculty of Medicine
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Local EPrints ID: 383066
URI: http://eprints.soton.ac.uk/id/eprint/383066
ISSN: 1053-0770
PURE UUID: cfbddbeb-1ae0-4260-bffe-d606190817e3
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Date deposited: 23 Oct 2015 14:17
Last modified: 15 Mar 2024 03:05
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Author:
Jake Tempo
Author:
David C. Smith
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