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Extra-intestinal pathogenic Escherichia coli (ExPEC): Disease, carriage and clones

Extra-intestinal pathogenic Escherichia coli (ExPEC): Disease, carriage and clones
Extra-intestinal pathogenic Escherichia coli (ExPEC): Disease, carriage and clones
Extra-intestinal pathogenic Escherichiacoli (ExPEC) have a complex phylogeny, broad virulence factor (VF) armament and significant genomic plasticity, and are associated with a spectrum of host infective syndromes ranging from simple urinary tract infection to life-threatening bacteraemia. Their importance as pathogens has come to the fore in recent years, particularly in the context of the global emergence of hyper-virulent and antibiotic resistant strains. Despite this, the mechanisms underlying ExPEC transmission dynamics and clonal selection remain poorly understood. Large-scale epidemiological and clinical studies are urgently required to ascertain the mechanisms underlying these processes to enable the development of novel evidence-based preventative and therapeutic strategies. In the current review, we provide a concise summary of the methods utilised for ExPEC phylogenetic delineation before exploring in detail the associations between ExPEC VFs and site-specific disease. We then consider the role of ExPEC as an intestinal colonist and outline known associations between ExPEC clonal variation, specific disease syndromes and antibiotic resistance.
escherichiacoli, ExPEC, virulence factors, clones
0163-4453
Dale, Adam P.
0d7cad74-5341-4991-aba2-061caab87809
Woodford, Neil
067c13bf-6686-45c6-90db-131eedf3ddc0
Dale, Adam P.
0d7cad74-5341-4991-aba2-061caab87809
Woodford, Neil
067c13bf-6686-45c6-90db-131eedf3ddc0

Dale, Adam P. and Woodford, Neil (2015) Extra-intestinal pathogenic Escherichia coli (ExPEC): Disease, carriage and clones. Journal of Infection. (doi:10.1016/j.jinf.2015.09.009). (PMID:26409905)

Record type: Article

Abstract

Extra-intestinal pathogenic Escherichiacoli (ExPEC) have a complex phylogeny, broad virulence factor (VF) armament and significant genomic plasticity, and are associated with a spectrum of host infective syndromes ranging from simple urinary tract infection to life-threatening bacteraemia. Their importance as pathogens has come to the fore in recent years, particularly in the context of the global emergence of hyper-virulent and antibiotic resistant strains. Despite this, the mechanisms underlying ExPEC transmission dynamics and clonal selection remain poorly understood. Large-scale epidemiological and clinical studies are urgently required to ascertain the mechanisms underlying these processes to enable the development of novel evidence-based preventative and therapeutic strategies. In the current review, we provide a concise summary of the methods utilised for ExPEC phylogenetic delineation before exploring in detail the associations between ExPEC VFs and site-specific disease. We then consider the role of ExPEC as an intestinal colonist and outline known associations between ExPEC clonal variation, specific disease syndromes and antibiotic resistance.

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Accepted/In Press date: 16 September 2015
Published date: 2015
Keywords: escherichiacoli, ExPEC, virulence factors, clones
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 383290
URI: https://eprints.soton.ac.uk/id/eprint/383290
ISSN: 0163-4453
PURE UUID: fea61913-3769-4f70-82ef-3742622cb277

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Date deposited: 23 Oct 2015 13:47
Last modified: 17 Jul 2017 20:13

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