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The autonomic control of heart rate and insulin resistance in young adults

The autonomic control of heart rate and insulin resistance in young adults
The autonomic control of heart rate and insulin resistance in young adults
The pathophysiology of insulin resistance is unclear. A link between increased heart rate (HR) and insulin resistance suggests an association with sympathetic nervous system activity. To further evaluate this, we examined autonomic activity using spectral analysis of HR variability (HRV), which provides a measure of cardiac sympathovagal modulation, and related this to insulin sensitivity (Si) in 137 men and women (20 yr old). The HRV spectrum displays 2 major peaks: a high-frequency peak, reflecting vagal activity, and a low-frequency peak caused by vagal and sympathetic activity. The high-to-low ratio (HLratio) reflects sympathovagal balance. Si was measured, using the i.v. glucose tolerance test with minimal modeling, and HR data was derived from a 15-min supine electrocardiogram. Women were more insulin resistant than men (Si, 3.94 vs. 5.09 10(4) min(-1)/per pmol x L; P = 0.002), had higher HR (59 vs. 56 beats/min, P = 0.019), but had a higher HLratio (2.04 vs. 1.31, P = 0.001). In men (but not women), Si correlated with HR (r = -0.410, P = 0.001) and measures of HRV: HLratio (r = 0.291, P = 0.002) independently of body mass index. In conclusion, Si correlates with cardiac sympathovagal balance in men, but not women, suggesting gender differences in the autonomic modulation of insulin resistance.
0021-972X
1263-1267
Flanagan, D.E.
abd05b13-9b75-49b5-9579-583480f7bf57
Vaile, J.C.
546f4f1e-f8be-41e8-a3fc-42a57b1f9f33
Petley, G.W.
4f2da40b-3c7b-4adc-b75c-e24e62bb1cf0
Moore, V.M.
77a93864-2092-4bfa-aba4-316bdc350a06
Godsland, I.F.
3911b2cd-db00-460e-b390-9e7289becbe6
Cockington, R.A.
2809999b-9baa-411f-b8c0-548775b2955b
Robinson, J.S.
676469b1-61ad-4571-b868-6a5a2c19b843
Phillips, D.I.
b00fb72c-07bf-4484-8a98-a1163c85cbb9
Flanagan, D.E.
abd05b13-9b75-49b5-9579-583480f7bf57
Vaile, J.C.
546f4f1e-f8be-41e8-a3fc-42a57b1f9f33
Petley, G.W.
4f2da40b-3c7b-4adc-b75c-e24e62bb1cf0
Moore, V.M.
77a93864-2092-4bfa-aba4-316bdc350a06
Godsland, I.F.
3911b2cd-db00-460e-b390-9e7289becbe6
Cockington, R.A.
2809999b-9baa-411f-b8c0-548775b2955b
Robinson, J.S.
676469b1-61ad-4571-b868-6a5a2c19b843
Phillips, D.I.
b00fb72c-07bf-4484-8a98-a1163c85cbb9

Flanagan, D.E., Vaile, J.C., Petley, G.W., Moore, V.M., Godsland, I.F., Cockington, R.A., Robinson, J.S. and Phillips, D.I. (1999) The autonomic control of heart rate and insulin resistance in young adults. Journal of Clinical Endocrinology & Metabolism, 84 (4), 1263-1267. (doi:10.1210/jcem.84.4.5592#sthash.4UtTAm6E.dpuf). (PMID:10199765)

Record type: Article

Abstract

The pathophysiology of insulin resistance is unclear. A link between increased heart rate (HR) and insulin resistance suggests an association with sympathetic nervous system activity. To further evaluate this, we examined autonomic activity using spectral analysis of HR variability (HRV), which provides a measure of cardiac sympathovagal modulation, and related this to insulin sensitivity (Si) in 137 men and women (20 yr old). The HRV spectrum displays 2 major peaks: a high-frequency peak, reflecting vagal activity, and a low-frequency peak caused by vagal and sympathetic activity. The high-to-low ratio (HLratio) reflects sympathovagal balance. Si was measured, using the i.v. glucose tolerance test with minimal modeling, and HR data was derived from a 15-min supine electrocardiogram. Women were more insulin resistant than men (Si, 3.94 vs. 5.09 10(4) min(-1)/per pmol x L; P = 0.002), had higher HR (59 vs. 56 beats/min, P = 0.019), but had a higher HLratio (2.04 vs. 1.31, P = 0.001). In men (but not women), Si correlated with HR (r = -0.410, P = 0.001) and measures of HRV: HLratio (r = 0.291, P = 0.002) independently of body mass index. In conclusion, Si correlates with cardiac sympathovagal balance in men, but not women, suggesting gender differences in the autonomic modulation of insulin resistance.

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More information

Published date: April 1999
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 383387
URI: http://eprints.soton.ac.uk/id/eprint/383387
ISSN: 0021-972X
PURE UUID: 0d2ef5d7-e975-491e-9499-bdb001cbe54f
ORCID for G.W. Petley: ORCID iD orcid.org/0000-0002-3295-0444

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Date deposited: 29 Jan 2016 10:07
Last modified: 12 Nov 2019 01:58

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