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Effects of respiratory gas composition on transthoracic impedance

Effects of respiratory gas composition on transthoracic impedance
Effects of respiratory gas composition on transthoracic impedance
The transthoracic current generated during defibrillation comprises a cardiac and extracardiac component. Changes in impedance of transthoracic pathways will alter the transmyocardial current and may thus affect the outcome from defibrillation. The lungs comprise a large component of extracardiac tissue but the effects of different respiratory gases on transthoracic impedance has not been documented. We therefore measured transthoracic impedance (TTI) using different respiratory gas mixtures. TTI across self-adhesive defibrillation pads placed in the antero-apical position was measured at end-expiration using a 30 kHz low amplitude AC current. Ten healthy subjects aged 22-34 years (eight male) were studied whilst breathing alternate mixtures of air, 100% oxygen. 70% helium in 30% oxygen, and 70% nitrous oxide in 30% oxygen administered in a random sequence. There was no significant difference in TTI between any of the four respiratory gases. Therefore transthoracic current during defibrillation is unlikely to be affected by different respiratory gases. This is the first study to document that these respiratory gases do not change the impedance of transthoracic pathways.
transthoracic, transmyocardial, defibrillation, respiratory gases
0300-9572
193-195
Deakin, C.D.
560d993b-bbc9-4548-9990-272ed18a011d
McLaren, R.M.
9a11c858-cb9a-44c6-a5f2-4ad45ab974ac
Pack, L.S.
ac3faa2c-4606-44bd-991d-c0ae273e927c
Petley, G.W.
4f2da40b-3c7b-4adc-b75c-e24e62bb1cf0
Clewlow, F.
06b8840f-4ccd-48cc-9a1e-d89f4960960d
Dalrymple-Hay, M.J.
6d241503-b555-4b07-b038-e44d24e21767
Deakin, C.D.
560d993b-bbc9-4548-9990-272ed18a011d
McLaren, R.M.
9a11c858-cb9a-44c6-a5f2-4ad45ab974ac
Pack, L.S.
ac3faa2c-4606-44bd-991d-c0ae273e927c
Petley, G.W.
4f2da40b-3c7b-4adc-b75c-e24e62bb1cf0
Clewlow, F.
06b8840f-4ccd-48cc-9a1e-d89f4960960d
Dalrymple-Hay, M.J.
6d241503-b555-4b07-b038-e44d24e21767

Deakin, C.D., McLaren, R.M., Pack, L.S., Petley, G.W., Clewlow, F. and Dalrymple-Hay, M.J. (1998) Effects of respiratory gas composition on transthoracic impedance. Resuscitation, 38 (3), 193-195. (doi:10.1016/S0300-9572(98)00099-9). (PMID:9872641)

Record type: Article

Abstract

The transthoracic current generated during defibrillation comprises a cardiac and extracardiac component. Changes in impedance of transthoracic pathways will alter the transmyocardial current and may thus affect the outcome from defibrillation. The lungs comprise a large component of extracardiac tissue but the effects of different respiratory gases on transthoracic impedance has not been documented. We therefore measured transthoracic impedance (TTI) using different respiratory gas mixtures. TTI across self-adhesive defibrillation pads placed in the antero-apical position was measured at end-expiration using a 30 kHz low amplitude AC current. Ten healthy subjects aged 22-34 years (eight male) were studied whilst breathing alternate mixtures of air, 100% oxygen. 70% helium in 30% oxygen, and 70% nitrous oxide in 30% oxygen administered in a random sequence. There was no significant difference in TTI between any of the four respiratory gases. Therefore transthoracic current during defibrillation is unlikely to be affected by different respiratory gases. This is the first study to document that these respiratory gases do not change the impedance of transthoracic pathways.

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More information

Published date: 1 September 1998
Keywords: transthoracic, transmyocardial, defibrillation, respiratory gases
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 383389
URI: http://eprints.soton.ac.uk/id/eprint/383389
ISSN: 0300-9572
PURE UUID: d9ebf731-46da-4166-85b0-5c8e56240a2e
ORCID for G.W. Petley: ORCID iD orcid.org/0000-0002-3295-0444

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Date deposited: 19 Jan 2016 16:51
Last modified: 20 Jul 2019 01:16

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Contributors

Author: C.D. Deakin
Author: R.M. McLaren
Author: L.S. Pack
Author: G.W. Petley ORCID iD
Author: F. Clewlow
Author: M.J. Dalrymple-Hay

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