The University of Southampton
University of Southampton Institutional Repository

Pharmacological vasodilatation improves efficiency of rewarming from hypothermic cardiopulmonary bypass

Pharmacological vasodilatation improves efficiency of rewarming from hypothermic cardiopulmonary bypass
Pharmacological vasodilatation improves efficiency of rewarming from hypothermic cardiopulmonary bypass
An afterdrop in core temperature after hypothermic cardiopulmonary bypass (CPB) is related to inadequate peripheral rewarming. We proposed that pharmacological vasodilatation during rewarming on bypass would improve peripheral rewarming and reduce the degree of afterdrop. Fifty-nine of 120 patients were randomized to receive a sodium nitroprusside (SNP) infusion during the rewarming stage of hypothermic CPB. Mean systemic vascular resistance (SVR) during the rewarming phase of CPB was 1129 dyne s-1 cm-5 in the control group and 768 dyne s-1 m-5 in the SNP group (P < or = 0.001). Patients receiving SNP rewarmed to 37.0 degrees C faster (299 min vs 376 min; P = 0.003) and were extubated earlier (490 min vs 621 min; P = 0.001). Patients receiving SNP had a warmer mean peripheral temperature (MPT) (32.9 degrees C vs 32.4 degrees C; P = 0.05) on termination of CPB. Postoperative core temperature fell less in the SNP group (35.6 degrees C vs 35.2 degrees C; P = 0.01) as did MPT (31.8 degrees C vs 31.2 degrees C; P = 0.004). SNP-induced vasodilatation during rewarming from hypothermic CPB improves peripheral rewarming, reduces the degree of postoperative core and peripheral hypothermia and reduces time to extubation.
0007-0912
147-151
Deakin, C.D.
560d993b-bbc9-4548-9990-272ed18a011d
Petley, G.W.
4f2da40b-3c7b-4adc-b75c-e24e62bb1cf0
Smith, D.
217b19f1-7588-4d54-a062-8394eea6dea1
Deakin, C.D.
560d993b-bbc9-4548-9990-272ed18a011d
Petley, G.W.
4f2da40b-3c7b-4adc-b75c-e24e62bb1cf0
Smith, D.
217b19f1-7588-4d54-a062-8394eea6dea1

Deakin, C.D., Petley, G.W. and Smith, D. (1998) Pharmacological vasodilatation improves efficiency of rewarming from hypothermic cardiopulmonary bypass. British Journal of Anaesthesia, 81 (2), 147-151. (doi:10.1093/bja/81.2.147). (PMID:9813513)

Record type: Article

Abstract

An afterdrop in core temperature after hypothermic cardiopulmonary bypass (CPB) is related to inadequate peripheral rewarming. We proposed that pharmacological vasodilatation during rewarming on bypass would improve peripheral rewarming and reduce the degree of afterdrop. Fifty-nine of 120 patients were randomized to receive a sodium nitroprusside (SNP) infusion during the rewarming stage of hypothermic CPB. Mean systemic vascular resistance (SVR) during the rewarming phase of CPB was 1129 dyne s-1 cm-5 in the control group and 768 dyne s-1 m-5 in the SNP group (P < or = 0.001). Patients receiving SNP rewarmed to 37.0 degrees C faster (299 min vs 376 min; P = 0.003) and were extubated earlier (490 min vs 621 min; P = 0.001). Patients receiving SNP had a warmer mean peripheral temperature (MPT) (32.9 degrees C vs 32.4 degrees C; P = 0.05) on termination of CPB. Postoperative core temperature fell less in the SNP group (35.6 degrees C vs 35.2 degrees C; P = 0.01) as did MPT (31.8 degrees C vs 31.2 degrees C; P = 0.004). SNP-induced vasodilatation during rewarming from hypothermic CPB improves peripheral rewarming, reduces the degree of postoperative core and peripheral hypothermia and reduces time to extubation.

Full text not available from this repository.

More information

Published date: August 1998
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 383391
URI: http://eprints.soton.ac.uk/id/eprint/383391
ISSN: 0007-0912
PURE UUID: b71e1904-305f-44ea-a1d9-321b676c16d0
ORCID for G.W. Petley: ORCID iD orcid.org/0000-0002-3295-0444

Catalogue record

Date deposited: 19 Jan 2016 16:47
Last modified: 03 Dec 2019 01:59

Export record

Altmetrics

Contributors

Author: C.D. Deakin
Author: G.W. Petley ORCID iD
Author: D. Smith

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×