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Reference ranges of bone mineral density for women in southern England: the impact of local data on the diagnosis of osteoporosis.

Reference ranges of bone mineral density for women in southern England: the impact of local data on the diagnosis of osteoporosis.
Reference ranges of bone mineral density for women in southern England: the impact of local data on the diagnosis of osteoporosis.
The construction of reference ranges that accurately represent the population at large is essential for the correct identification of osteoporosis from bone mineral density (BMD) measurements. In this study, reference data supplied by the manufacturer of the Lunar DPX+ bone densitometer were compared with data obtained locally. Lumbar spine, proximal femur and total body BMD measurements were made in an age-stratified random sample of 702 Southampton women aged 20 to 89 years. Relevant demographic and medical data were recorded for each subject using a questionnaire. Reference curves of BMD (mean +/- SD) were plotted against age for each measurement site and were found to be higher than the manufacturer's reference values at all ages and sites. Exclusion of women with factors known to affect bone mass only served to increase this discrepancy. According to World Health Organisation definitions, osteoporosis may be identified from BMD values alone. Based upon neck of femur BMD values, 100 (14.8%) of the women in this study group were categorized as osteoporotic using local young normal reference data, compared with only 39 (5.8%) using the manufacturer's data. By normalizing for age distribution, these findings were extrapolated to the local population where it was predicted that 26.0% and 10.1% of females over 50 years of age would be classified as osteoporotic using the respective reference ranges. This study clearly illustrates how the numbers of women diagnosed as osteoporotic vary with the use of different reference populations.
0007-1285
655-660
Petley, G.W.
4f2da40b-3c7b-4adc-b75c-e24e62bb1cf0
Cotton, A.M.
7f474105-e79c-45fd-bc4d-475e99f97400
Murrills, A.J.
4874f921-548f-4ac4-9195-34326e37e6cd
Taylor, P.A.
9315d36c-6664-4d46-a422-f3d16ef4e7d5
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Cawley, M.I.
2b9c2f70-6486-43ed-a13b-c288d3b53676
Wilkin, T.J.
8c55ebbb-e547-445c-95a1-c8bed02dd652
Petley, G.W.
4f2da40b-3c7b-4adc-b75c-e24e62bb1cf0
Cotton, A.M.
7f474105-e79c-45fd-bc4d-475e99f97400
Murrills, A.J.
4874f921-548f-4ac4-9195-34326e37e6cd
Taylor, P.A.
9315d36c-6664-4d46-a422-f3d16ef4e7d5
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Cawley, M.I.
2b9c2f70-6486-43ed-a13b-c288d3b53676
Wilkin, T.J.
8c55ebbb-e547-445c-95a1-c8bed02dd652

Petley, G.W., Cotton, A.M., Murrills, A.J., Taylor, P.A., Cooper, C., Cawley, M.I. and Wilkin, T.J. (1996) Reference ranges of bone mineral density for women in southern England: the impact of local data on the diagnosis of osteoporosis. British Journal of Radiology, 69 (823), 655-660. (doi:10.1259/0007-1285-69-823-655). (PMID:9059309)

Record type: Article

Abstract

The construction of reference ranges that accurately represent the population at large is essential for the correct identification of osteoporosis from bone mineral density (BMD) measurements. In this study, reference data supplied by the manufacturer of the Lunar DPX+ bone densitometer were compared with data obtained locally. Lumbar spine, proximal femur and total body BMD measurements were made in an age-stratified random sample of 702 Southampton women aged 20 to 89 years. Relevant demographic and medical data were recorded for each subject using a questionnaire. Reference curves of BMD (mean +/- SD) were plotted against age for each measurement site and were found to be higher than the manufacturer's reference values at all ages and sites. Exclusion of women with factors known to affect bone mass only served to increase this discrepancy. According to World Health Organisation definitions, osteoporosis may be identified from BMD values alone. Based upon neck of femur BMD values, 100 (14.8%) of the women in this study group were categorized as osteoporotic using local young normal reference data, compared with only 39 (5.8%) using the manufacturer's data. By normalizing for age distribution, these findings were extrapolated to the local population where it was predicted that 26.0% and 10.1% of females over 50 years of age would be classified as osteoporotic using the respective reference ranges. This study clearly illustrates how the numbers of women diagnosed as osteoporotic vary with the use of different reference populations.

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More information

Published date: July 1996
Organisations: Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 383395
URI: https://eprints.soton.ac.uk/id/eprint/383395
ISSN: 0007-1285
PURE UUID: 9810277c-866c-4c71-9e59-b92b266ea59d
ORCID for G.W. Petley: ORCID iD orcid.org/0000-0002-3295-0444
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 18 Jan 2016 11:22
Last modified: 06 Jun 2018 13:01

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