The University of Southampton
University of Southampton Institutional Repository

The regulation of feeding and metabolism in response to food deprivation in Caenorhabditis elegans

The regulation of feeding and metabolism in response to food deprivation in Caenorhabditis elegans
The regulation of feeding and metabolism in response to food deprivation in Caenorhabditis elegans
This review considers the factors involved in the regulation of feeding and metabolism in response to food deprivation using Caenorhabditis elegans as a model organism. Some of the sensory neurons and interneurons involved in food intake are described, together with an overview of pharyngeal pumping. A number of chemical transmitters control feeding in C. elegans including 5-hydroxytryptamine (5-HT, serotonin), acetylcholine, glutamate, dopamine, octopamine, and tyramine. The roles of these transmitters are modified by neuropeptides, including FMRFamide-like peptides (FLPs), neuropeptide-like protein (NLPs), and insulin-like peptides. The precise effects of many of these neuropeptides have yet to be elucidated but increasingly they are being shown to play a role in feeding and metabolism in C. elegans. The regulation of fat stores is complex and appears to involve the expression of a large number of genes, many with mammalian homologues, suggesting that fat regulatory signalling is conserved across phyla. Finally, a brief comparison is made between C. elegans and mammals where for both, despite their evolutionary distance, classical transmitters and neuropeptides have anorectic or orexigenic properties. Thus, there is a rationale to support the argument that an understanding of the molecular and genetic basis of feeding and fat regulation in C. elegans may contribute to efforts aimed at the identification of targets for the treatment of conditions associated with abnormal metabolism and obesity
c. elegans, metabolism, feeding, fat storage, 5-hydroxytryptamine, food deprivation
1354-2516
63-76
Luedtke, S.
7ccd4b60-94ab-49d4-a899-e36b2fdc7825
O'Connor, V.
8021b06c-01a0-4925-9dde-a61c8fe278ca
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, R.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Luedtke, S.
7ccd4b60-94ab-49d4-a899-e36b2fdc7825
O'Connor, V.
8021b06c-01a0-4925-9dde-a61c8fe278ca
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, R.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140

Luedtke, S., O'Connor, V., Holden-Dye, L. and Walker, R. (2010) The regulation of feeding and metabolism in response to food deprivation in Caenorhabditis elegans. Invertebrate Neuroscience, 10 (2), 63-76. (doi:10.1007/s 10158-010-0112). (PMID:21120572)

Record type: Article

Abstract

This review considers the factors involved in the regulation of feeding and metabolism in response to food deprivation using Caenorhabditis elegans as a model organism. Some of the sensory neurons and interneurons involved in food intake are described, together with an overview of pharyngeal pumping. A number of chemical transmitters control feeding in C. elegans including 5-hydroxytryptamine (5-HT, serotonin), acetylcholine, glutamate, dopamine, octopamine, and tyramine. The roles of these transmitters are modified by neuropeptides, including FMRFamide-like peptides (FLPs), neuropeptide-like protein (NLPs), and insulin-like peptides. The precise effects of many of these neuropeptides have yet to be elucidated but increasingly they are being shown to play a role in feeding and metabolism in C. elegans. The regulation of fat stores is complex and appears to involve the expression of a large number of genes, many with mammalian homologues, suggesting that fat regulatory signalling is conserved across phyla. Finally, a brief comparison is made between C. elegans and mammals where for both, despite their evolutionary distance, classical transmitters and neuropeptides have anorectic or orexigenic properties. Thus, there is a rationale to support the argument that an understanding of the molecular and genetic basis of feeding and fat regulation in C. elegans may contribute to efforts aimed at the identification of targets for the treatment of conditions associated with abnormal metabolism and obesity

Full text not available from this repository.

More information

Published date: 1 December 2010
Keywords: c. elegans, metabolism, feeding, fat storage, 5-hydroxytryptamine, food deprivation
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 383636
URI: http://eprints.soton.ac.uk/id/eprint/383636
ISSN: 1354-2516
PURE UUID: 0254b861-6693-40cf-bfdb-83fa2c0de975
ORCID for L. Holden-Dye: ORCID iD orcid.org/0000-0002-9704-1217
ORCID for R. Walker: ORCID iD orcid.org/0000-0002-9031-7671

Catalogue record

Date deposited: 19 Nov 2015 09:21
Last modified: 18 Feb 2021 17:37

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×