Nicotine acetylcholine receptors: a comparison of the nAChRs of Caenorhabditis elegans and parasitic nematodes
Nicotine acetylcholine receptors: a comparison of the nAChRs of Caenorhabditis elegans and parasitic nematodes
Nicotinic acetylcholine receptors (nAChRs) play a key role in the normal physiology of nematodes and provide an established target site for anthelmintics. The free-living nematode, Caenorhabditis elegans, has a large number of nAChR subunit genes in its genome and so provides an experimental model for testing novel anthelmintics which act at these sites. However, many parasitic nematodes lack specific genes present in C. elegans, and so care is required in extrapolating from studies using C. elegans to the situation in other nematodes. In this review the properties of C. elegans nAChRs are reviewed and compared to those of parasitic nematodes. This forms the basis for a discussion of the possible subunit composition of nAChRs from different species of parasitic nematodes. Currently our knowledge on this is largely based on studies using heterologous expression and pharmacological analysis of receptor subunits in Xenopus laevis oocytes. It is concluded that more information is required regarding the subunit composition and pharmacology of endogenous nAChRs in parasitic nematodes
606-615
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Joyner, M.
b065329b-522a-42eb-b52e-044114008f60
O'Connor, V.
8021b06c-01a0-4925-9dde-a61c8fe278ca
Walker, R.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
December 2013
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Joyner, M.
b065329b-522a-42eb-b52e-044114008f60
O'Connor, V.
8021b06c-01a0-4925-9dde-a61c8fe278ca
Walker, R.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Holden-Dye, L., Joyner, M., O'Connor, V. and Walker, R.
(2013)
Nicotine acetylcholine receptors: a comparison of the nAChRs of Caenorhabditis elegans and parasitic nematodes.
Parasitology International, 62 (6), .
(doi:10.1016/j.parint.2013.03.004).
(PMID:23500392)
Abstract
Nicotinic acetylcholine receptors (nAChRs) play a key role in the normal physiology of nematodes and provide an established target site for anthelmintics. The free-living nematode, Caenorhabditis elegans, has a large number of nAChR subunit genes in its genome and so provides an experimental model for testing novel anthelmintics which act at these sites. However, many parasitic nematodes lack specific genes present in C. elegans, and so care is required in extrapolating from studies using C. elegans to the situation in other nematodes. In this review the properties of C. elegans nAChRs are reviewed and compared to those of parasitic nematodes. This forms the basis for a discussion of the possible subunit composition of nAChRs from different species of parasitic nematodes. Currently our knowledge on this is largely based on studies using heterologous expression and pharmacological analysis of receptor subunits in Xenopus laevis oocytes. It is concluded that more information is required regarding the subunit composition and pharmacology of endogenous nAChRs in parasitic nematodes
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Published date: December 2013
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 383646
URI: http://eprints.soton.ac.uk/id/eprint/383646
ISSN: 1383-5769
PURE UUID: 539f1f1d-ba3b-431a-ab2e-5cf3a76d6ad0
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Date deposited: 19 Nov 2015 12:02
Last modified: 15 Mar 2024 04:03
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Author:
M. Joyner
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