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Anthelmintic drugs and nematocides: studies in Caenorhabditis elegans

Anthelmintic drugs and nematocides: studies in Caenorhabditis elegans
Anthelmintic drugs and nematocides: studies in Caenorhabditis elegans
Parasitic nematodes infect many species of animals throughout the phyla, including humans. Moreover, nematodes that parasitise plants are a global problem for agriculture. As such, these nematodes place a major burden on human health, on livestock production, on the welfare of companion animals and on crop production. In the 21st century there are two major challenges posed by the wide-spread prevalence of parasitic nematodes. First, many anthelmintic drugs are losing their effectiveness because nematode strains with resistance are emerging. Second, serious concerns regarding the environmental impact of the nematicides used for crop protection have prompted legislation to remove them from use, leaving agriculture at increased risk from nematode pests. There is clearly a need for a concerted effort to address these challenges. Over the last few decades the free-living nematode Caenorhabditis elegans has provided the opportunity to use molecular genetic techniques for mode of action studies for anthelmintics and nematicides. These approaches continue to be of considerable value. Less fruitful so far, but nonetheless potentially very useful, has been the direct use of C. elegans for anthelmintic and nematicide discovery programmes. Here we provide an introduction to the use of C. elegans as a ‘model’ parasitic nematode, briefly review the study of nematode control using C. elegans and highlight approaches that have been of particular value with a view to facilitating wider-use of C. elegans as a platform for anthelmintic and nematicide discovery and development
1-29
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, R.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Maricq, A.V.
49d4d8e1-1548-4ea6-8a1d-7eeb2b23bd76
Holden-Dye, L.
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, R.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Maricq, A.V.
49d4d8e1-1548-4ea6-8a1d-7eeb2b23bd76

Holden-Dye, L. and Walker, R. , Maricq, A.V. (ed.) (2014) Anthelmintic drugs and nematocides: studies in Caenorhabditis elegans. WormBook: The Online Review of C. elegans Biology, 1-29. (doi:10.1895/wormbook.1.143.2). (PMID:25517625)

Record type: Article

Abstract

Parasitic nematodes infect many species of animals throughout the phyla, including humans. Moreover, nematodes that parasitise plants are a global problem for agriculture. As such, these nematodes place a major burden on human health, on livestock production, on the welfare of companion animals and on crop production. In the 21st century there are two major challenges posed by the wide-spread prevalence of parasitic nematodes. First, many anthelmintic drugs are losing their effectiveness because nematode strains with resistance are emerging. Second, serious concerns regarding the environmental impact of the nematicides used for crop protection have prompted legislation to remove them from use, leaving agriculture at increased risk from nematode pests. There is clearly a need for a concerted effort to address these challenges. Over the last few decades the free-living nematode Caenorhabditis elegans has provided the opportunity to use molecular genetic techniques for mode of action studies for anthelmintics and nematicides. These approaches continue to be of considerable value. Less fruitful so far, but nonetheless potentially very useful, has been the direct use of C. elegans for anthelmintic and nematicide discovery programmes. Here we provide an introduction to the use of C. elegans as a ‘model’ parasitic nematode, briefly review the study of nematode control using C. elegans and highlight approaches that have been of particular value with a view to facilitating wider-use of C. elegans as a platform for anthelmintic and nematicide discovery and development

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More information

Published date: 2014
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 383647
URI: http://eprints.soton.ac.uk/id/eprint/383647
PURE UUID: f08072dc-1dd9-445a-8510-2f645d93f700
ORCID for L. Holden-Dye: ORCID iD orcid.org/0000-0002-9704-1217
ORCID for R. Walker: ORCID iD orcid.org/0000-0002-9031-7671

Catalogue record

Date deposited: 19 Nov 2015 12:14
Last modified: 17 Dec 2019 02:04

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