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Slow diffusion in situ ruthenium/ligand reaction: crystal structures, fluorescence and biological properties

Slow diffusion in situ ruthenium/ligand reaction: crystal structures, fluorescence and biological properties
Slow diffusion in situ ruthenium/ligand reaction: crystal structures, fluorescence and biological properties
Promoted by RuCl3·3H2O coordination in the mixed solvent DMF/H2O, diverse in situ S–S bond reactions such as S–S bond scission and S-oxidation occurred in the disulfide ligand of 2,2?-dithiodibenzoic acid (dtdb) to yield the new sulfinato-benzoate ligand (sb). The X-ray analysis of complexes of [Ru(phen)2(sb)] (1) and [Ru(bipy)2(sb)·H2O] (2) revealed that in both complexes, the ruthenium ion was found to be in an octahedral geometry, coordinating to the sulfur atom, rather than the oxygen of sulfinate. The complexes were found to be active against the bacterial strains tested with MIC ranging from 14.3–261 ?M. In addition, the metal complexes present strong DNA binding affinity constants in the major or minor grooves at the order of magnitude 105-106 M? 1. The antioxidant activities of the ligand and its metal complexes were investigated through scavenging effects for DPPH in vitro, indicating that the compounds show stronger activities than some standard antioxidants, such as ascorbic and vitamin C.
71-76
Moosun, S.B.
6b8f3ee5-45bb-437b-81e3-911e988ef023
Jhaumeer-Laulloo, S.
27441110-45c1-4cec-8dbd-29239a88df19
Coles, S.J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Blair, L.H.
72ef952d-a161-42ff-a793-545deb97c794
Hosten, E.C.
47241033-3eba-4271-a1a9-645e2eaa8e97
Bhowon, M.G.
25c04db0-3327-489a-87e2-0c811ad57598
Moosun, S.B.
6b8f3ee5-45bb-437b-81e3-911e988ef023
Jhaumeer-Laulloo, S.
27441110-45c1-4cec-8dbd-29239a88df19
Coles, S.J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Blair, L.H.
72ef952d-a161-42ff-a793-545deb97c794
Hosten, E.C.
47241033-3eba-4271-a1a9-645e2eaa8e97
Bhowon, M.G.
25c04db0-3327-489a-87e2-0c811ad57598

Moosun, S.B., Jhaumeer-Laulloo, S., Coles, S.J., Blair, L.H., Hosten, E.C. and Bhowon, M.G. (2015) Slow diffusion in situ ruthenium/ligand reaction: crystal structures, fluorescence and biological properties. Inorganic Chemistry Communications, 62, 71-76. (doi:10.1016/j.inoche.2015.10.019).

Record type: Article

Abstract

Promoted by RuCl3·3H2O coordination in the mixed solvent DMF/H2O, diverse in situ S–S bond reactions such as S–S bond scission and S-oxidation occurred in the disulfide ligand of 2,2?-dithiodibenzoic acid (dtdb) to yield the new sulfinato-benzoate ligand (sb). The X-ray analysis of complexes of [Ru(phen)2(sb)] (1) and [Ru(bipy)2(sb)·H2O] (2) revealed that in both complexes, the ruthenium ion was found to be in an octahedral geometry, coordinating to the sulfur atom, rather than the oxygen of sulfinate. The complexes were found to be active against the bacterial strains tested with MIC ranging from 14.3–261 ?M. In addition, the metal complexes present strong DNA binding affinity constants in the major or minor grooves at the order of magnitude 105-106 M? 1. The antioxidant activities of the ligand and its metal complexes were investigated through scavenging effects for DPPH in vitro, indicating that the compounds show stronger activities than some standard antioxidants, such as ascorbic and vitamin C.

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Accepted/In Press date: 13 October 2015
e-pub ahead of print date: 20 October 2015
Published date: December 2015
Organisations: Chemistry

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Local EPrints ID: 383693
URI: http://eprints.soton.ac.uk/id/eprint/383693
PURE UUID: f1e70201-0858-4023-8786-aefad1498b34
ORCID for S.J. Coles: ORCID iD orcid.org/0000-0001-8414-9272

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Date deposited: 09 Nov 2015 12:44
Last modified: 15 Sep 2021 01:43

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Contributors

Author: S.B. Moosun
Author: S. Jhaumeer-Laulloo
Author: S.J. Coles ORCID iD
Author: L.H. Blair
Author: E.C. Hosten
Author: M.G. Bhowon

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