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13C-aminopyrine demethylation is decreased in cirrhotic patients with normal biochemical markers

13C-aminopyrine demethylation is decreased in cirrhotic patients with normal biochemical markers
13C-aminopyrine demethylation is decreased in cirrhotic patients with normal biochemical markers
This study determined the rates of (13)C-aminopyrine metabolism in patients with varying degrees of liver cirrhosis as defined by clinical scores. Twenty-five cirrhotic patients and 18 healthy subjects underwent a (13)C-aminopyrine breath test. The cumulative per cent dose recovery (cPDR) of (13)C on breath expressed as a percentage of the administered dose at 2 h was significantly lower in cirrhotic patients than in healthy subjects (median: 1.7% versus 9.0%; p<.0001). Significant inverse associations between cPDR at 2 h and the model for end-stage liver disease score, Child-Pugh score, international normalised ratio and bilirubin (all p<.05), but not alanine aminotransferase or alkaline phosphatase were observed in the cirrhotic patients. Taking each biochemical marker independently, cirrhotic patients with normal biochemistry had a significantly lower cPDR at 2 h than healthy subjects (all p<.05). Differences in (13)C-aminopyrine metabolism were evident in cirrhotic patients with less severe disease and may mark hepatic dysfunction when conventional biochemical markers appear unchanged
biochemical markers, 13C-aminopyrine breath test, carbon-13, child–pugh score, cirrhosis, health, hepatic function, human, isotope application in medicine, stable isotope tracer techniques
1025-6016
346-356
Afolabi, Paul
757e7f01-664c-493e-bc51-c6a2c933dc22
Wright, Mark
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Wootton, Steve A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Afolabi, Paul
757e7f01-664c-493e-bc51-c6a2c933dc22
Wright, Mark
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Wootton, Steve A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef

Afolabi, Paul, Wright, Mark, Wootton, Steve A. and Jackson, Alan A. (2013) 13C-aminopyrine demethylation is decreased in cirrhotic patients with normal biochemical markers. Isotopes in Environmental and Health Studies, 49 (3), 346-356. (doi:10.1080/10256016.2013.803098). (PMID:23799253)

Record type: Article

Abstract

This study determined the rates of (13)C-aminopyrine metabolism in patients with varying degrees of liver cirrhosis as defined by clinical scores. Twenty-five cirrhotic patients and 18 healthy subjects underwent a (13)C-aminopyrine breath test. The cumulative per cent dose recovery (cPDR) of (13)C on breath expressed as a percentage of the administered dose at 2 h was significantly lower in cirrhotic patients than in healthy subjects (median: 1.7% versus 9.0%; p<.0001). Significant inverse associations between cPDR at 2 h and the model for end-stage liver disease score, Child-Pugh score, international normalised ratio and bilirubin (all p<.05), but not alanine aminotransferase or alkaline phosphatase were observed in the cirrhotic patients. Taking each biochemical marker independently, cirrhotic patients with normal biochemistry had a significantly lower cPDR at 2 h than healthy subjects (all p<.05). Differences in (13)C-aminopyrine metabolism were evident in cirrhotic patients with less severe disease and may mark hepatic dysfunction when conventional biochemical markers appear unchanged

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More information

Accepted/In Press date: 22 March 2013
Published date: 25 June 2013
Keywords: biochemical markers, 13C-aminopyrine breath test, carbon-13, child–pugh score, cirrhosis, health, hepatic function, human, isotope application in medicine, stable isotope tracer techniques
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 383787
URI: http://eprints.soton.ac.uk/id/eprint/383787
ISSN: 1025-6016
PURE UUID: 06e4394f-d6bc-45e9-a044-514361ba9128
ORCID for Paul Afolabi: ORCID iD orcid.org/0000-0002-0553-1578

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Date deposited: 23 Nov 2015 11:43
Last modified: 08 Nov 2023 02:35

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Contributors

Author: Paul Afolabi ORCID iD
Author: Mark Wright
Author: Alan A. Jackson

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