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Effect of fatty acid chain length and saturation on the gastrointestinal handling and metabolic disposal of dietary fatty acids in women

Effect of fatty acid chain length and saturation on the gastrointestinal handling and metabolic disposal of dietary fatty acids in women
Effect of fatty acid chain length and saturation on the gastrointestinal handling and metabolic disposal of dietary fatty acids in women
The gastrointestinal handling and metabolic disposal of [1-13C]palmitic acid, [1-13C]stearic acid and [1-13C]oleic acid administered within a lipid-casein-glucose-sucrose emulsion were examined in normal healthy women by determining both the amount and nature of the 13C label in stool and label excreted on breath as 13CO2. The greatest excretion of 13C label in stool was in the stearic acid trial (9.2% of administered dose) whilst comparatively little label was observed in stool in either the palmitic acid (1.2% of administered dose) or oleic acid (1.9% of administered dose) trials. In both the palmitic acid and oleic acid trials, all of the label in stool was identified as being present in the form in which it was administered (i.e. [13C]palmitic acid in the palmitic acid trial and [13C]oleic acid in the oleic acid trial). In contrast, only 87% of the label in the stool in the stearic acid trial was identified as [13C]stearic acid, the remainder was identified as [13C]palmitic acid which may reflect chain shortening of [1-13C]stearic acid within the gastrointestinal tract. Small, but statistically significant, differences were observed in the time course of recovery of 13C label on breath over the initial 9 h of the study period (oleic acid = palmitic acid > stearic acid). However, when calculated over the 24 h study period, the recovery of the label as 13CO2 was similar in all three trials (approximately 25% of absorbed dose). These results support the view that chain length and degree of unsaturation may influence the gastrointestinal handling and immediate metabolic disposal of these fatty acids even when presented within an emulsion.
fatty acids, postprandial lipid metabolism, stable isotopes
0007-1145
37-43
Jones, A.E.
61f65ad1-ae5c-47f6-b159-63aa6a5178b5
Stolinski, M.
56fb652b-6b99-4aac-adf4-01f49a03b080
Smith, R.D.
513e9ddc-d10d-4a54-ad55-4cb7e439620d
Murphy, J.L.
99e7863d-f870-438a-b4f5-bec8a2e78ebd
Wootton, S.A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jones, A.E.
61f65ad1-ae5c-47f6-b159-63aa6a5178b5
Stolinski, M.
56fb652b-6b99-4aac-adf4-01f49a03b080
Smith, R.D.
513e9ddc-d10d-4a54-ad55-4cb7e439620d
Murphy, J.L.
99e7863d-f870-438a-b4f5-bec8a2e78ebd
Wootton, S.A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c

Jones, A.E., Stolinski, M., Smith, R.D., Murphy, J.L. and Wootton, S.A. (1999) Effect of fatty acid chain length and saturation on the gastrointestinal handling and metabolic disposal of dietary fatty acids in women. British Journal of Nutrition, 81 (1), 37-43. (doi:10.1017/S0007114599000124). (PMID:10341674)

Record type: Article

Abstract

The gastrointestinal handling and metabolic disposal of [1-13C]palmitic acid, [1-13C]stearic acid and [1-13C]oleic acid administered within a lipid-casein-glucose-sucrose emulsion were examined in normal healthy women by determining both the amount and nature of the 13C label in stool and label excreted on breath as 13CO2. The greatest excretion of 13C label in stool was in the stearic acid trial (9.2% of administered dose) whilst comparatively little label was observed in stool in either the palmitic acid (1.2% of administered dose) or oleic acid (1.9% of administered dose) trials. In both the palmitic acid and oleic acid trials, all of the label in stool was identified as being present in the form in which it was administered (i.e. [13C]palmitic acid in the palmitic acid trial and [13C]oleic acid in the oleic acid trial). In contrast, only 87% of the label in the stool in the stearic acid trial was identified as [13C]stearic acid, the remainder was identified as [13C]palmitic acid which may reflect chain shortening of [1-13C]stearic acid within the gastrointestinal tract. Small, but statistically significant, differences were observed in the time course of recovery of 13C label on breath over the initial 9 h of the study period (oleic acid = palmitic acid > stearic acid). However, when calculated over the 24 h study period, the recovery of the label as 13CO2 was similar in all three trials (approximately 25% of absorbed dose). These results support the view that chain length and degree of unsaturation may influence the gastrointestinal handling and immediate metabolic disposal of these fatty acids even when presented within an emulsion.

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Published date: January 1999
Keywords: fatty acids, postprandial lipid metabolism, stable isotopes
Organisations: Human Development & Health

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Local EPrints ID: 383842
URI: http://eprints.soton.ac.uk/id/eprint/383842
ISSN: 0007-1145
PURE UUID: c741bd4e-07e6-4ab2-8d5b-5388d4d277a0

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Date deposited: 25 Nov 2015 15:16
Last modified: 15 Jul 2019 20:58

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Contributors

Author: A.E. Jones
Author: M. Stolinski
Author: R.D. Smith
Author: J.L. Murphy
Author: S.A. Wootton

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