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A nuclear singlet lifetime of more than one hour in room-temperature solution

A nuclear singlet lifetime of more than one hour in room-temperature solution
A nuclear singlet lifetime of more than one hour in room-temperature solution
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude.
long-lived spin states, NMR spectroscopy, nuclear spin relaxation, singlet states
1433-7851
3740-3743
Stevanato, Gabriele
13f2e0a2-2ce7-4938-a2ac-274a81196a72
Hill-Cousins, Joseph T.
3fd2a389-1612-4d9d-8322-afcc0c401ada
Håkansson, Pär
814e08b5-ae95-408f-a669-bec9c0ef4235
Roy, Soumya Singha
68482787-af96-47cc-8bfc-e2834e7fcffe
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3
Stevanato, Gabriele
13f2e0a2-2ce7-4938-a2ac-274a81196a72
Hill-Cousins, Joseph T.
3fd2a389-1612-4d9d-8322-afcc0c401ada
Håkansson, Pär
814e08b5-ae95-408f-a669-bec9c0ef4235
Roy, Soumya Singha
68482787-af96-47cc-8bfc-e2834e7fcffe
Brown, Lynda J.
75aa95fa-5d27-46a7-9dbe-0f465a664f5b
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Pileio, Giuseppe
13f78e66-0707-4438-b9c9-6dbd3eb7d4e8
Levitt, Malcolm H.
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3

Stevanato, Gabriele, Hill-Cousins, Joseph T., Håkansson, Pär, Roy, Soumya Singha, Brown, Lynda J., Brown, Richard C.D., Pileio, Giuseppe and Levitt, Malcolm H. (2015) A nuclear singlet lifetime of more than one hour in room-temperature solution. Angewandte Chemie International Edition, 54 (12), 3740-3743. (doi:10.1002/anie.201411978).

Record type: Article

Abstract

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude.

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Published date: 28 January 2015
Keywords: long-lived spin states, NMR spectroscopy, nuclear spin relaxation, singlet states
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Magnetic Resonance

Identifiers

Local EPrints ID: 383951
URI: https://eprints.soton.ac.uk/id/eprint/383951
ISSN: 1433-7851
PURE UUID: a5191e46-512b-44ae-8fdc-b0153c9244a2
ORCID for Lynda J. Brown: ORCID iD orcid.org/0000-0002-5678-0814
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087
ORCID for Giuseppe Pileio: ORCID iD orcid.org/0000-0001-9223-3896
ORCID for Malcolm H. Levitt: ORCID iD orcid.org/0000-0001-9878-1180

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Date deposited: 01 Dec 2015 12:14
Last modified: 20 Jul 2019 01:16

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