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Genetic factors associated with exercise performance in atmospheric hypoxia

Genetic factors associated with exercise performance in atmospheric hypoxia
Genetic factors associated with exercise performance in atmospheric hypoxia
The small number of articles identified in the current review and the limited number of polymorphisms studied in total highlights that the influence of genetic factors on exercise performance in hypoxia has not been studied in depth, which precludes firm conclusions being drawn. Support for the association between the ACE-I allele and improved high-altitude performance was the strongest, with three studies identifying a relationship. Analysis of study quality highlights the need for future studies in this field to improve the conduct and reporting of genetic association studies.
0112-1642
745-761
Hennis, Philip J.
b3563308-2f8e-49fb-a73f-c5afcc177ffe
O'Doherty, Alasdair F.
4f379e38-368f-416c-9ad3-250dd16de9ba
Levett, Denny Z.H.
4b33b751-32be-4fa3-aaf7-b62e62f08de8
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Montgomery, Hugh M.
0496478d-6028-4d54-b9f1-aaff2a96789a
Hennis, Philip J.
b3563308-2f8e-49fb-a73f-c5afcc177ffe
O'Doherty, Alasdair F.
4f379e38-368f-416c-9ad3-250dd16de9ba
Levett, Denny Z.H.
4b33b751-32be-4fa3-aaf7-b62e62f08de8
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Montgomery, Hugh M.
0496478d-6028-4d54-b9f1-aaff2a96789a

Hennis, Philip J., O'Doherty, Alasdair F., Levett, Denny Z.H., Grocott, Michael P.W. and Montgomery, Hugh M. (2015) Genetic factors associated with exercise performance in atmospheric hypoxia. Sports Medicine, 45 (5), 745-761. (doi:10.1007/s40279-015-0309-8). (PMID:25682119)

Record type: Article

Abstract

The small number of articles identified in the current review and the limited number of polymorphisms studied in total highlights that the influence of genetic factors on exercise performance in hypoxia has not been studied in depth, which precludes firm conclusions being drawn. Support for the association between the ACE-I allele and improved high-altitude performance was the strongest, with three studies identifying a relationship. Analysis of study quality highlights the need for future studies in this field to improve the conduct and reporting of genetic association studies.

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e-pub ahead of print date: 15 February 2015
Published date: May 2015
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 384049
URI: http://eprints.soton.ac.uk/id/eprint/384049
ISSN: 0112-1642
PURE UUID: ee1c9d59-02dc-43f3-b367-c20b17148c25
ORCID for Michael P.W. Grocott: ORCID iD orcid.org/0000-0002-9484-7581

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Date deposited: 08 Dec 2015 14:28
Last modified: 15 Mar 2024 03:33

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Contributors

Author: Philip J. Hennis
Author: Alasdair F. O'Doherty
Author: Denny Z.H. Levett
Author: Hugh M. Montgomery

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