Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation


Sanborn, Matthew R., Edsell, Mark E., Kim, Meeri N., Mesquita, Rickson, Putt, Mary E., Imray, Chris, Yow, Heng, Wilson, Mark H., Yodh, Arjun G., Grocott, Mike and Martin, Daniel S. (2015) Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation Wilderness and Environmental Medicine, 26, (2), pp. 133-141. (doi:10.1016/j.wem.2014.10.001). (PMID:25797567).

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Description/Abstract

An intensification of the normal cerebral hypocapnic vasoconstrictive response occurred after partial acclimatization in the setting of divergent peripheral and cerebral oxygenation. This may help explain why hyperventilation fails to improve cerebral oxygenation after partial acclimatization as it does after initial ascent. The use of DCS is feasible at altitude and provides a direct measure of CBF indices with high temporal resolution.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.wem.2014.10.001
ISSNs: 1080-6032 (print)
Keywords: altitude, cerebral oxygenation, hypoxia
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Organisations: Clinical & Experimental Sciences
ePrint ID: 384055
Date :
Date Event
18 March 2015e-pub ahead of print
June 2015Published
Date Deposited: 08 Dec 2015 14:53
Last Modified: 17 Apr 2017 04:48
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/384055

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