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Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation

Sanborn, Matthew R., Edsell, Mark E., Kim, Meeri N., Mesquita, Rickson, Putt, Mary E., Imray, Chris, Yow, Heng, Wilson, Mark H., Yodh, Arjun G., Grocott, Mike and Martin, Daniel S. (2015) Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation Wilderness and Environmental Medicine, 26, (2), pp. 133-141. (doi:10.1016/j.wem.2014.10.001). (PMID:25797567).

Record type: Article

Abstract

An intensification of the normal cerebral hypocapnic vasoconstrictive response occurred after partial acclimatization in the setting of divergent peripheral and cerebral oxygenation. This may help explain why hyperventilation fails to improve cerebral oxygenation after partial acclimatization as it does after initial ascent. The use of DCS is feasible at altitude and provides a direct measure of CBF indices with high temporal resolution.

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More information

e-pub ahead of print date: 18 March 2015
Published date: June 2015
Keywords: altitude, cerebral oxygenation, hypoxia
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 384055
URI: http://eprints.soton.ac.uk/id/eprint/384055
ISSN: 1080-6032
PURE UUID: 999df154-8a73-4fc1-af0b-cac0b2b2aac8

Catalogue record

Date deposited: 08 Dec 2015 14:53
Last modified: 17 Jul 2017 20:08

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Contributors

Author: Matthew R. Sanborn
Author: Mark E. Edsell
Author: Meeri N. Kim
Author: Rickson Mesquita
Author: Mary E. Putt
Author: Chris Imray
Author: Heng Yow
Author: Mark H. Wilson
Author: Arjun G. Yodh
Author: Mike Grocott
Author: Daniel S. Martin

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