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Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation

Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation
Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation
An intensification of the normal cerebral hypocapnic vasoconstrictive response occurred after partial acclimatization in the setting of divergent peripheral and cerebral oxygenation. This may help explain why hyperventilation fails to improve cerebral oxygenation after partial acclimatization as it does after initial ascent. The use of DCS is feasible at altitude and provides a direct measure of CBF indices with high temporal resolution.
altitude, cerebral oxygenation, hypoxia
1080-6032
133-141
Sanborn, Matthew R.
0374b6f1-ccc5-4e98-9cb8-e3adb911daa5
Edsell, Mark E.
8bbc5b9f-ad3b-46fc-a65d-c8bc49ff9d9c
Kim, Meeri N.
edf017c2-0f65-4c89-93ef-bd44f13d9033
Mesquita, Rickson
f6002614-8879-4b73-a7c6-fb4cebb9db78
Putt, Mary E.
2782dce1-2a55-48e3-9f42-8a1546eb7c24
Imray, Chris
9a0e3001-e8d6-4614-bf95-8f3fb6c6f942
Yow, Heng
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Wilson, Mark H.
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Yodh, Arjun G.
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Grocott, Mike
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Martin, Daniel S.
f60d19f8-d4a0-44e2-b9b5-e6f18de00cd7
Sanborn, Matthew R.
0374b6f1-ccc5-4e98-9cb8-e3adb911daa5
Edsell, Mark E.
8bbc5b9f-ad3b-46fc-a65d-c8bc49ff9d9c
Kim, Meeri N.
edf017c2-0f65-4c89-93ef-bd44f13d9033
Mesquita, Rickson
f6002614-8879-4b73-a7c6-fb4cebb9db78
Putt, Mary E.
2782dce1-2a55-48e3-9f42-8a1546eb7c24
Imray, Chris
9a0e3001-e8d6-4614-bf95-8f3fb6c6f942
Yow, Heng
84fa3be1-f38a-41e1-8bdc-21f32eea3f20
Wilson, Mark H.
9a48b1f2-494b-42cf-a02c-c0a0e9967d33
Yodh, Arjun G.
2b67919a-03a2-4513-9181-b1d2e29334aa
Grocott, Mike
1e87b741-513e-4a22-be13-0f7bb344e8c2
Martin, Daniel S.
f60d19f8-d4a0-44e2-b9b5-e6f18de00cd7

Sanborn, Matthew R., Edsell, Mark E., Kim, Meeri N., Mesquita, Rickson, Putt, Mary E., Imray, Chris, Yow, Heng, Wilson, Mark H., Yodh, Arjun G., Grocott, Mike and Martin, Daniel S. (2015) Cerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenation Wilderness and Environmental Medicine, 26, (2), pp. 133-141. (doi:10.1016/j.wem.2014.10.001). (PMID:25797567).

Record type: Article

Abstract

An intensification of the normal cerebral hypocapnic vasoconstrictive response occurred after partial acclimatization in the setting of divergent peripheral and cerebral oxygenation. This may help explain why hyperventilation fails to improve cerebral oxygenation after partial acclimatization as it does after initial ascent. The use of DCS is feasible at altitude and provides a direct measure of CBF indices with high temporal resolution.

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More information

e-pub ahead of print date: 18 March 2015
Published date: June 2015
Keywords: altitude, cerebral oxygenation, hypoxia
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 384055
URI: http://eprints.soton.ac.uk/id/eprint/384055
ISSN: 1080-6032
PURE UUID: 999df154-8a73-4fc1-af0b-cac0b2b2aac8

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Date deposited: 08 Dec 2015 14:53
Last modified: 17 Jul 2017 20:08

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Contributors

Author: Matthew R. Sanborn
Author: Mark E. Edsell
Author: Meeri N. Kim
Author: Rickson Mesquita
Author: Mary E. Putt
Author: Chris Imray
Author: Heng Yow
Author: Mark H. Wilson
Author: Arjun G. Yodh
Author: Mike Grocott
Author: Daniel S. Martin

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