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Laser-polymerised fluidic channels for the manufacture of multiplexed paper-based diagnostic sensors

Laser-polymerised fluidic channels for the manufacture of multiplexed paper-based diagnostic sensors
Laser-polymerised fluidic channels for the manufacture of multiplexed paper-based diagnostic sensors
Paper-based microfluidics is a rapidly progressing inter-disciplinary technology driven by the need for low-cost alternatives to conventional point-of-care diagnostic tools. For transport of reagents/analytes, such devices often consist of interconnected hydrophilic fluid-flow channels that are demarcated by hydrophobic barrier walls that extend through the thickness of the paper. Here, we present a laser-based fabrication procedure that uses laser-induced polymerisation of a photopolymer to produce the required fluidic channels in paper or other porous materials. Experimental results showed that the structures successfully guide the flow of fluids and also allow containment of fluids in wells, and hence the technique is suitable for fabrication of paper-based microfluidic devices.
The minimum width for the hydrophobic barriers that successfully prevented fluid leakage was ~120 µm and the minimum width for the fluidic channels that can be formed was ~80 µm, the smallest reported so far for paper-based fluidic patterns. The patterns can be produced rapidly using simple low power c.w. laser sources at a writing speed of order 1 ms-1 and we have successfully demonstrated techniques for controlled delay, forward biased and multiplexed flow of several different fluids. We show our early results for diagnostic paper-based sensors for the detection of glucose and bovine serum albumin (BSA) using colorometric readout, which we believe makes the technique especially useful for mass-market applications, particularly in developing world situations where simplicity, cheapness and ready availability are the key parameters.
Eason, R.W.
e38684c3-d18c-41b9-a4aa-def67283b020
Katis, I.N.
f92dfb8f-610d-4877-83f6-fd26a571df12
He, P.J.W.
2e303166-6aa5-4a09-b22e-440d96a54a9f
Sones, C.L.
9de9d8ee-d394-46a5-80b7-e341c0eed0a8
Eason, R.W.
e38684c3-d18c-41b9-a4aa-def67283b020
Katis, I.N.
f92dfb8f-610d-4877-83f6-fd26a571df12
He, P.J.W.
2e303166-6aa5-4a09-b22e-440d96a54a9f
Sones, C.L.
9de9d8ee-d394-46a5-80b7-e341c0eed0a8

Eason, R.W., Katis, I.N., He, P.J.W. and Sones, C.L. (2015) Laser-polymerised fluidic channels for the manufacture of multiplexed paper-based diagnostic sensors. PR15 conference. 16 - 19 Jun 2015.

Record type: Conference or Workshop Item (Paper)

Abstract

Paper-based microfluidics is a rapidly progressing inter-disciplinary technology driven by the need for low-cost alternatives to conventional point-of-care diagnostic tools. For transport of reagents/analytes, such devices often consist of interconnected hydrophilic fluid-flow channels that are demarcated by hydrophobic barrier walls that extend through the thickness of the paper. Here, we present a laser-based fabrication procedure that uses laser-induced polymerisation of a photopolymer to produce the required fluidic channels in paper or other porous materials. Experimental results showed that the structures successfully guide the flow of fluids and also allow containment of fluids in wells, and hence the technique is suitable for fabrication of paper-based microfluidic devices.
The minimum width for the hydrophobic barriers that successfully prevented fluid leakage was ~120 µm and the minimum width for the fluidic channels that can be formed was ~80 µm, the smallest reported so far for paper-based fluidic patterns. The patterns can be produced rapidly using simple low power c.w. laser sources at a writing speed of order 1 ms-1 and we have successfully demonstrated techniques for controlled delay, forward biased and multiplexed flow of several different fluids. We show our early results for diagnostic paper-based sensors for the detection of glucose and bovine serum albumin (BSA) using colorometric readout, which we believe makes the technique especially useful for mass-market applications, particularly in developing world situations where simplicity, cheapness and ready availability are the key parameters.

Full text not available from this repository.

More information

Published date: 2015
Venue - Dates: PR15 conference, 2015-06-16 - 2015-06-19
Organisations: Optoelectronics Research Centre

Identifiers

Local EPrints ID: 384194
URI: https://eprints.soton.ac.uk/id/eprint/384194
PURE UUID: bddafc97-5d79-49d3-94b5-2ce02bb95965
ORCID for R.W. Eason: ORCID iD orcid.org/0000-0001-9704-2204
ORCID for I.N. Katis: ORCID iD orcid.org/0000-0002-2016-557X

Catalogue record

Date deposited: 19 Nov 2015 11:36
Last modified: 20 Nov 2018 01:36

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