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Altered executive control network resting-state connectivity in social anxiety disorder

Altered executive control network resting-state connectivity in social anxiety disorder
Altered executive control network resting-state connectivity in social anxiety disorder
Objectives: Research into the neural basis of social anxiety disorder (SAD) suggests alterations in prefrontal networks, which may in turn disrupt regulation of the limbic system. Better understanding of the disturbed interface between these networks may improve current pathogenic models of this disorder. Methods: Applying group independent component analysis (ICA) to recordings of fMRI resting-state, connectivity in the executive control network was studied in 18 patients with SAD and 15 age- and sex-matched healthy controls. Results: Results revealed a dissociation within the left executive control network, with SAD patients showing decreased connectivity of the orbitofrontal gyrus and increased connectivity of the middle frontal gyrus compared to healthy controls. In a subsequent seed-based functional connectivity analysis, patients with SAD displayed increased connectivity between the left orbitofrontal gyrus and the left amygdala. Conclusions: Findings suggest that hypo-connectivity in the executive control network and hyper-connectivity between the orbitofrontal cortex and the amygdala may reflect a disturbance in the balance between top-down and bottom-up control processes, potentially contributing to the development of SAD.
social phobia, fMRI, attention, prefrontal cortex, amygdala
1562-2975
Geiger, M.
7bfe09cc-6574-4a77-8440-09c0470c10b8
Domschke, K.
ae5d05a8-9d5e-4512-a3a9-89776fc70958
Ipser, J.
db7f348c-d05c-4ab8-8dae-a1dce98b5f73
Hattingh, C.
eb0c8699-f948-4780-815f-664038cf513f
Baldwin, D.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Lochner, C.
eb1e42d1-2b6e-4a58-9fc9-f4df433ad369
Stein, D.
a1a51daf-171d-4b8c-88ca-13e893aeb17d
Geiger, M.
7bfe09cc-6574-4a77-8440-09c0470c10b8
Domschke, K.
ae5d05a8-9d5e-4512-a3a9-89776fc70958
Ipser, J.
db7f348c-d05c-4ab8-8dae-a1dce98b5f73
Hattingh, C.
eb0c8699-f948-4780-815f-664038cf513f
Baldwin, D.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Lochner, C.
eb1e42d1-2b6e-4a58-9fc9-f4df433ad369
Stein, D.
a1a51daf-171d-4b8c-88ca-13e893aeb17d

Geiger, M., Domschke, K., Ipser, J., Hattingh, C., Baldwin, D., Lochner, C. and Stein, D. (2015) Altered executive control network resting-state connectivity in social anxiety disorder. The World Journal of Biological Psychiatry. (doi:10.3109/15622975.2015.1083613).

Record type: Article

Abstract

Objectives: Research into the neural basis of social anxiety disorder (SAD) suggests alterations in prefrontal networks, which may in turn disrupt regulation of the limbic system. Better understanding of the disturbed interface between these networks may improve current pathogenic models of this disorder. Methods: Applying group independent component analysis (ICA) to recordings of fMRI resting-state, connectivity in the executive control network was studied in 18 patients with SAD and 15 age- and sex-matched healthy controls. Results: Results revealed a dissociation within the left executive control network, with SAD patients showing decreased connectivity of the orbitofrontal gyrus and increased connectivity of the middle frontal gyrus compared to healthy controls. In a subsequent seed-based functional connectivity analysis, patients with SAD displayed increased connectivity between the left orbitofrontal gyrus and the left amygdala. Conclusions: Findings suggest that hypo-connectivity in the executive control network and hyper-connectivity between the orbitofrontal cortex and the amygdala may reflect a disturbance in the balance between top-down and bottom-up control processes, potentially contributing to the development of SAD.

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Accepted/In Press date: 12 August 2015
e-pub ahead of print date: 9 October 2015
Keywords: social phobia, fMRI, attention, prefrontal cortex, amygdala
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 384250
URI: https://eprints.soton.ac.uk/id/eprint/384250
ISSN: 1562-2975
PURE UUID: b16173a9-bb65-401b-bc02-14c81aad98b5

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Date deposited: 21 Dec 2015 10:27
Last modified: 17 Jul 2017 20:06

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Contributors

Author: M. Geiger
Author: K. Domschke
Author: J. Ipser
Author: C. Hattingh
Author: D. Baldwin
Author: C. Lochner
Author: D. Stein

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