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CNS inflammation other than multiple sclerosis: how likely is diagnosis?

CNS inflammation other than multiple sclerosis: how likely is diagnosis?
CNS inflammation other than multiple sclerosis: how likely is diagnosis?
The incidence, diagnostic landscape, and workload impact of CNS inflammatory diseases other than multiple sclerosis (MS) (CIDOMS) in a tertiary setting is unknown. We describe a retrospective case series of 64 patients identified over a 2-year period (2009–2010) at the Wessex Neurological Centre in the United Kingdom, accounting for 4% of all patients seen at the center. As expected, neurosarcoidosis and neuromyelitis optica (NMO) were the most common diagnoses reached (14% each); other diagnoses singly accounted for <10%. However, the likeliest diagnostic outcome (strikingly, in 25%) was nondiagnosis, despite intensive investigation and a mean follow-up period of 3 years. Undiagnosed patients with CIDOMS represented the largest workload of the neurology center
0028-3878
1187-1189
Street, Duncan
bfdbe379-a7d8-4913-82cb-576aff9e2200
Halfpenny, Christopher A.
ba7d88de-5bbc-4d18-b1c9-8cf5c48fe020
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Street, Duncan
bfdbe379-a7d8-4913-82cb-576aff9e2200
Halfpenny, Christopher A.
ba7d88de-5bbc-4d18-b1c9-8cf5c48fe020
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b

Street, Duncan, Halfpenny, Christopher A. and Galea, Ian (2014) CNS inflammation other than multiple sclerosis: how likely is diagnosis? Neurology, 82 (13), 1187-1189. (doi:10.1212/WNL.0000000000000273). (PMID:21422462)

Record type: Article

Abstract

The incidence, diagnostic landscape, and workload impact of CNS inflammatory diseases other than multiple sclerosis (MS) (CIDOMS) in a tertiary setting is unknown. We describe a retrospective case series of 64 patients identified over a 2-year period (2009–2010) at the Wessex Neurological Centre in the United Kingdom, accounting for 4% of all patients seen at the center. As expected, neurosarcoidosis and neuromyelitis optica (NMO) were the most common diagnoses reached (14% each); other diagnoses singly accounted for <10%. However, the likeliest diagnostic outcome (strikingly, in 25%) was nondiagnosis, despite intensive investigation and a mean follow-up period of 3 years. Undiagnosed patients with CIDOMS represented the largest workload of the neurology center

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e-pub ahead of print date: 28 February 2014
Published date: 1 April 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 384273
URI: https://eprints.soton.ac.uk/id/eprint/384273
ISSN: 0028-3878
PURE UUID: b16dd7db-46d3-412d-9fcb-02332b26b2fd
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

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Date deposited: 30 Nov 2015 09:41
Last modified: 06 Jun 2018 12:46

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