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Laser-based patterning for fluidic devices in nitrocellulose

Laser-based patterning for fluidic devices in nitrocellulose
Laser-based patterning for fluidic devices in nitrocellulose
In this report, we demonstrate a simple and low cost method that can be reproducibly used for fabrication of microfluidic devices in nitrocellulose. The fluidic patterns are created via a laser-based direct-write technique that induces polymerisation of a photo-polymer previously impregnated in the nitrocellulose. The resulting structures form hydrophobic barriers that extend through the thickness of the nitrocellulose and define an interconnected hydrophilic fluidic-flow pattern. Our experimental results show that using this method it is possible to achieve microfluidic channels with lateral dimensions of ~100µm using hydrophobic barriers that form the channel walls with dimensions of ~60µm; both of these values are considerably smaller than those that can be achieved with other current techniques used in the fabrication of nitrocellulose-based fluidic devices. A simple grid patterned nitrocellulose device was then used for the detection of C-reactive protein via a sandwich enzyme-linked immunosorbent assay, which served as a useful proof-of-principle experiment.
1932-1058
1-10
He, Peijun
2e303166-6aa5-4a09-b22e-440d96a54a9f
Katis, Ioannis
f92dfb8f-610d-4877-83f6-fd26a571df12
Eason, Robert W.
e38684c3-d18c-41b9-a4aa-def67283b020
Sones, Collin L.
9de9d8ee-d394-46a5-80b7-e341c0eed0a8
He, Peijun
2e303166-6aa5-4a09-b22e-440d96a54a9f
Katis, Ioannis
f92dfb8f-610d-4877-83f6-fd26a571df12
Eason, Robert W.
e38684c3-d18c-41b9-a4aa-def67283b020
Sones, Collin L.
9de9d8ee-d394-46a5-80b7-e341c0eed0a8

He, Peijun, Katis, Ioannis, Eason, Robert W. and Sones, Collin L. (2015) Laser-based patterning for fluidic devices in nitrocellulose. Biomicrofluidics, 9 (2), 1-10. (doi:10.1063/1.4919629).

Record type: Article

Abstract

In this report, we demonstrate a simple and low cost method that can be reproducibly used for fabrication of microfluidic devices in nitrocellulose. The fluidic patterns are created via a laser-based direct-write technique that induces polymerisation of a photo-polymer previously impregnated in the nitrocellulose. The resulting structures form hydrophobic barriers that extend through the thickness of the nitrocellulose and define an interconnected hydrophilic fluidic-flow pattern. Our experimental results show that using this method it is possible to achieve microfluidic channels with lateral dimensions of ~100µm using hydrophobic barriers that form the channel walls with dimensions of ~60µm; both of these values are considerably smaller than those that can be achieved with other current techniques used in the fabrication of nitrocellulose-based fluidic devices. A simple grid patterned nitrocellulose device was then used for the detection of C-reactive protein via a sandwich enzyme-linked immunosorbent assay, which served as a useful proof-of-principle experiment.

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More information

Accepted/In Press date: 21 April 2015
Published date: 29 April 2015
Organisations: Optoelectronics Research Centre

Identifiers

Local EPrints ID: 384364
URI: https://eprints.soton.ac.uk/id/eprint/384364
ISSN: 1932-1058
PURE UUID: 68f943bd-53e6-4da8-9a2b-4a95e1fa2415
ORCID for Ioannis Katis: ORCID iD orcid.org/0000-0002-2016-557X
ORCID for Robert W. Eason: ORCID iD orcid.org/0000-0001-9704-2204

Catalogue record

Date deposited: 01 Dec 2015 15:15
Last modified: 26 Nov 2019 02:06

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Contributors

Author: Peijun He
Author: Ioannis Katis ORCID iD
Author: Robert W. Eason ORCID iD
Author: Collin L. Sones

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