The University of Southampton
University of Southampton Institutional Repository

Prevention and treatment of Staphylococcus aureus biofilms

Prevention and treatment of Staphylococcus aureus biofilms
Prevention and treatment of Staphylococcus aureus biofilms
S. aureus colonizes both artificial and tissue surfaces in humans causing chronic persistent infections that are difficult to cure. It is a notorious pathogen due to its antibiotic recalcitrance and phenotypic adaptability, both of which are facilitated by its ability to develop biofilms. S. aureus biofilms challenge conventional anti-infective approaches, most notably antibiotic therapy. Therefore there is an unmet need to develop and include parallel approaches that target S. aureus biofilm infections. This review discusses two broad anti-infective strategies: (1) preventative approaches (anti-biofilm surface coatings, the inclusion of biofilm-specific vaccine antigens); and (2) approaches aimed at eradicating established S. aureus biofilms, particularly those associated with implant infections. Advances in understanding the distinct nature of S. aureus biofilm development and pathogenesis have led to growing optimism in S. aureus biofilm targeted anti-infective strategies. Further research is needed however, to see the successful administration and validation of these approaches to the diverse types of infections caused by S. aureus biofilms from multiple clinical strains
Staphylococcus aureus, biofilm infections, persistence, antibiotic tolerance, anti-infective strategies, device related infections, prosthetic implants
1744-8336
1499-1516
Bhattacharya, Mohini
021ee792-e3c4-4f42-b0fb-aad753455263
Wozniak, Daniel J.
bfa8e8e5-5929-449b-af6a-ec2d86c47eb5
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Hall-Stoodley, Luanne
94ebdc00-b549-4488-b15f-5310fb965f5b
Bhattacharya, Mohini
021ee792-e3c4-4f42-b0fb-aad753455263
Wozniak, Daniel J.
bfa8e8e5-5929-449b-af6a-ec2d86c47eb5
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Hall-Stoodley, Luanne
94ebdc00-b549-4488-b15f-5310fb965f5b

Bhattacharya, Mohini, Wozniak, Daniel J., Stoodley, Paul and Hall-Stoodley, Luanne (2015) Prevention and treatment of Staphylococcus aureus biofilms. Expert Review of Anti-Infective Therapy, 13 (12), 1499-1516. (doi:10.1586/14787210.2015.1100533).

Record type: Article

Abstract

S. aureus colonizes both artificial and tissue surfaces in humans causing chronic persistent infections that are difficult to cure. It is a notorious pathogen due to its antibiotic recalcitrance and phenotypic adaptability, both of which are facilitated by its ability to develop biofilms. S. aureus biofilms challenge conventional anti-infective approaches, most notably antibiotic therapy. Therefore there is an unmet need to develop and include parallel approaches that target S. aureus biofilm infections. This review discusses two broad anti-infective strategies: (1) preventative approaches (anti-biofilm surface coatings, the inclusion of biofilm-specific vaccine antigens); and (2) approaches aimed at eradicating established S. aureus biofilms, particularly those associated with implant infections. Advances in understanding the distinct nature of S. aureus biofilm development and pathogenesis have led to growing optimism in S. aureus biofilm targeted anti-infective strategies. Further research is needed however, to see the successful administration and validation of these approaches to the diverse types of infections caused by S. aureus biofilms from multiple clinical strains

Full text not available from this repository.

More information

Published date: 13 November 2015
Keywords: Staphylococcus aureus, biofilm infections, persistence, antibiotic tolerance, anti-infective strategies, device related infections, prosthetic implants
Organisations: Engineering Science Unit

Identifiers

Local EPrints ID: 384466
URI: https://eprints.soton.ac.uk/id/eprint/384466
ISSN: 1744-8336
PURE UUID: e92bef05-087f-4648-af17-2f8489d72b84
ORCID for Paul Stoodley: ORCID iD orcid.org/0000-0001-6069-273X

Catalogue record

Date deposited: 21 Dec 2015 14:52
Last modified: 19 Jul 2019 20:26

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×