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Halbach arrays consisting of cubic elements optimised for high field gradients in magnetic drug targeting applications

Halbach arrays consisting of cubic elements optimised for high field gradients in magnetic drug targeting applications
Halbach arrays consisting of cubic elements optimised for high field gradients in magnetic drug targeting applications
A key challenge in the development of magnetic drug targeting (MDT) as a clinically relevant technique is designing systems that can apply sufficient magnetic force to actuate magnetic drug carriers at useful tissue depths. In this study an optimisation routine was developed to generate designs of Halbach arrays consisting of multiple layers of high grade, cubic, permanent magnet elements, configured to deliver the maximum pull or push force at a position of interest between 5 and 50?mm from the array, resulting in arrays capable of delivering useful magnetic forces to depths past 20?mm. The optimisation routine utilises a numerical model of the magnetic field and force generated by an arbitrary configuration of magnetic elements. Simulated field and force profiles of optimised arrays were evaluated, also taking into account the forces required for assembling the array in practice. The resultant selection for the array, consisting of two layers, was then constructed and characterised to verify the simulations. Finally the array was utilised in a set of in vitro experiments to demonstrate its capacity to separate and retain microbubbles loaded with magnetic nanoparticles against a constant flow. The optimised designs are presented as light-weight, inexpensive options for applying high-gradient, external magnetic fields in MDT applications.
8303-8327
Barnsley, Lester C.
da7b9324-6305-4b35-8e4e-0f4a6410aa25
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Owen, Joshua
b5d9c311-b8d4-40db-b937-65a769a11b4f
Stride, Eleanor
c0143e95-81fa-47c8-b9bc-5b4fc319bba6
Barnsley, Lester C.
da7b9324-6305-4b35-8e4e-0f4a6410aa25
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Owen, Joshua
b5d9c311-b8d4-40db-b937-65a769a11b4f
Stride, Eleanor
c0143e95-81fa-47c8-b9bc-5b4fc319bba6

Barnsley, Lester C., Carugo, Dario, Owen, Joshua and Stride, Eleanor (2015) Halbach arrays consisting of cubic elements optimised for high field gradients in magnetic drug targeting applications. Physics in Medicine and Biology, 60 (21), 8303-8327. (doi:10.1088/0031-9155/60/21/8303). (PMID:26458056)

Record type: Article

Abstract

A key challenge in the development of magnetic drug targeting (MDT) as a clinically relevant technique is designing systems that can apply sufficient magnetic force to actuate magnetic drug carriers at useful tissue depths. In this study an optimisation routine was developed to generate designs of Halbach arrays consisting of multiple layers of high grade, cubic, permanent magnet elements, configured to deliver the maximum pull or push force at a position of interest between 5 and 50?mm from the array, resulting in arrays capable of delivering useful magnetic forces to depths past 20?mm. The optimisation routine utilises a numerical model of the magnetic field and force generated by an arbitrary configuration of magnetic elements. Simulated field and force profiles of optimised arrays were evaluated, also taking into account the forces required for assembling the array in practice. The resultant selection for the array, consisting of two layers, was then constructed and characterised to verify the simulations. Finally the array was utilised in a set of in vitro experiments to demonstrate its capacity to separate and retain microbubbles loaded with magnetic nanoparticles against a constant flow. The optimised designs are presented as light-weight, inexpensive options for applying high-gradient, external magnetic fields in MDT applications.

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More information

Accepted/In Press date: 25 August 2015
e-pub ahead of print date: 12 October 2015
Published date: 7 November 2015
Organisations: Bioengineering Group, Mechatronics

Identifiers

Local EPrints ID: 384536
URI: https://eprints.soton.ac.uk/id/eprint/384536
PURE UUID: 80f249b7-a9b5-4452-9601-4defe5e73ba4

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Date deposited: 06 Jan 2016 16:48
Last modified: 17 Jul 2017 20:04

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Contributors

Author: Lester C. Barnsley
Author: Dario Carugo
Author: Joshua Owen
Author: Eleanor Stride

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