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Low-grade inflammation, diet composition and health: current research evidence and its translation.

Low-grade inflammation, diet composition and health: current research evidence and its translation.
Low-grade inflammation, diet composition and health: current research evidence and its translation.
The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled ‘Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies’. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation–health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation–health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims.
low-grade inflammation, biomarkers, chronic diseases, health claims
0007-1145
999-1012
Minihane, A.M.
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Vinoy, S.
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Russell, W.R.
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Baka, A.
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Roche, H.M.
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Tuohy, K.M.
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Teeling, J.L.
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Blaak, E.E.
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Fenech, M.
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Vauzour, D.
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McArdle, H.J.
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Kremer, B.H.
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Sterkman, L.
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Vafeiadou, K.
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Benedetti, M.M.
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Williams, C.M.
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Calder, P.
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Minihane, A.M.
a9124733-1ef9-4cdd-965a-126ab13d9817
Vinoy, S.
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Russell, W.R.
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Baka, A.
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Roche, H.M.
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Tuohy, K.M.
cb406f1b-073e-4981-917d-e7bdbaecc083
Teeling, J.L.
857ad97a-abce-4e6c-8cee-a32e0de81341
Blaak, E.E.
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Fenech, M.
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Vauzour, D.
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McArdle, H.J.
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Kremer, B.H.
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Sterkman, L.
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Vafeiadou, K.
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Benedetti, M.M.
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Williams, C.M.
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Calder, P.
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Minihane, A.M., Vinoy, S., Russell, W.R., Baka, A., Roche, H.M., Tuohy, K.M., Teeling, J.L., Blaak, E.E., Fenech, M., Vauzour, D., McArdle, H.J., Kremer, B.H., Sterkman, L., Vafeiadou, K., Benedetti, M.M., Williams, C.M. and Calder, P. (2015) Low-grade inflammation, diet composition and health: current research evidence and its translation. British Journal of Nutrition, 114 (7), 999-1012. (doi:10.1017/S0007114515002093). (PMID:26228057)

Record type: Review

Abstract

The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled ‘Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies’. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation–health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation–health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims.

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More information

Accepted/In Press date: 18 May 2015
e-pub ahead of print date: 31 July 2015
Published date: October 2015
Keywords: low-grade inflammation, biomarkers, chronic diseases, health claims
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 384756
URI: http://eprints.soton.ac.uk/id/eprint/384756
ISSN: 0007-1145
PURE UUID: ccb1482f-fefa-42ca-b814-a4310b3626f1
ORCID for P. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 13 Jan 2016 09:06
Last modified: 15 Mar 2024 02:50

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Contributors

Author: A.M. Minihane
Author: S. Vinoy
Author: W.R. Russell
Author: A. Baka
Author: H.M. Roche
Author: K.M. Tuohy
Author: J.L. Teeling
Author: E.E. Blaak
Author: M. Fenech
Author: D. Vauzour
Author: H.J. McArdle
Author: B.H. Kremer
Author: L. Sterkman
Author: K. Vafeiadou
Author: M.M. Benedetti
Author: C.M. Williams
Author: P. Calder ORCID iD

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