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Cachexia, sarcopenia, inflammaging and outcomes in hospitalised Older people (the CaSIO study) study protocol and preliminary results

Cachexia, sarcopenia, inflammaging and outcomes in hospitalised Older people (the CaSIO study) study protocol and preliminary results
Cachexia, sarcopenia, inflammaging and outcomes in hospitalised Older people (the CaSIO study) study protocol and preliminary results
Introduction
Older people admitted to hospital are vulnerable to adverse outcomes including prolonged length of stay, reduced mobility, admission to care homes. Cachexia, sarcopenia and inflammaging are age-related conditions associated with poor outcomes but are little characterised in older people admitted to hospital. The aim of this study was to describe in detail a cohort of hospitalised older people with focus on cachexia, sarcopenia, inflammaging and clinical outcomes.

Materials and methods
CaSIO was a prospective, cohort study of hospitalised older women, with a follow-up time over 2 years. Participants were recruited from the Medicine for Older People wards at a university hospital in England. Detailed characterisation of cachexia, sarcopenia and the immune-endocrine axis occurred on admission, discharge and at 6 months post-discharge. Outcome data were collected on the length of hospital admission, discharge destination, and longer-term outcomes including functional status at six month follow-up. Mortality data were collected at 6, 12 and 24 months.

Results
145 female participants (58% of eligible patients) were recruited and survived the admission with an average age 86 years; baseline characteristics are provided. 103 (71%) were re-assessed 6 months after discharge (18 (12%) had died; 24 (17%) were lost to follow up); mortality data was ascertained at 12 and 24 months.

Conclusion
This study has described cachexia, sarcopenia and inflammaging in relation to clinical outcomes in hospitalised older women with 6 month follow up and mortality data collected for 24 months. This will add to a greater understanding of these conditions within older people.
cachexia, sarcopenia, inflammaging, inflammation, ageing
1878-7649
495-501
Baylis, D.
81f774ef-9139-48bd-8360-d20ebedaa492
Syddall, H.
a0181a93-8fc3-4998-a996-7963f0128328
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Lord, M.
3b8b59f2-76dd-4e58-a9f8-f3200dac41b9
Roberts, H.C.
5ea688b1-ef7a-4173-9da0-26290e18f253
Aihie Sayer, A
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Baylis, D.
81f774ef-9139-48bd-8360-d20ebedaa492
Syddall, H.
a0181a93-8fc3-4998-a996-7963f0128328
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Lord, M.
3b8b59f2-76dd-4e58-a9f8-f3200dac41b9
Roberts, H.C.
5ea688b1-ef7a-4173-9da0-26290e18f253
Aihie Sayer, A
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb

Baylis, D., Syddall, H., Jameson, K.A., Cooper, C., Lord, M., Roberts, H.C. and Aihie Sayer, A (2015) Cachexia, sarcopenia, inflammaging and outcomes in hospitalised Older people (the CaSIO study) study protocol and preliminary results. European Geriatric Medicine, 6 (5), 495-501. (doi:10.1016/j.eurger.2015.06.004).

Record type: Article

Abstract

Introduction
Older people admitted to hospital are vulnerable to adverse outcomes including prolonged length of stay, reduced mobility, admission to care homes. Cachexia, sarcopenia and inflammaging are age-related conditions associated with poor outcomes but are little characterised in older people admitted to hospital. The aim of this study was to describe in detail a cohort of hospitalised older people with focus on cachexia, sarcopenia, inflammaging and clinical outcomes.

Materials and methods
CaSIO was a prospective, cohort study of hospitalised older women, with a follow-up time over 2 years. Participants were recruited from the Medicine for Older People wards at a university hospital in England. Detailed characterisation of cachexia, sarcopenia and the immune-endocrine axis occurred on admission, discharge and at 6 months post-discharge. Outcome data were collected on the length of hospital admission, discharge destination, and longer-term outcomes including functional status at six month follow-up. Mortality data were collected at 6, 12 and 24 months.

Results
145 female participants (58% of eligible patients) were recruited and survived the admission with an average age 86 years; baseline characteristics are provided. 103 (71%) were re-assessed 6 months after discharge (18 (12%) had died; 24 (17%) were lost to follow up); mortality data was ascertained at 12 and 24 months.

Conclusion
This study has described cachexia, sarcopenia and inflammaging in relation to clinical outcomes in hospitalised older women with 6 month follow up and mortality data collected for 24 months. This will add to a greater understanding of these conditions within older people.

Full text not available from this repository.

More information

Accepted/In Press date: 7 June 2015
e-pub ahead of print date: 15 August 2015
Published date: October 2015
Keywords: cachexia, sarcopenia, inflammaging, inflammation, ageing
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 384765
URI: https://eprints.soton.ac.uk/id/eprint/384765
ISSN: 1878-7649
PURE UUID: f2f13957-cd60-410c-9a73-bb413c87cc60
ORCID for H. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 13 Jan 2016 10:29
Last modified: 06 Jun 2018 13:00

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Contributors

Author: D. Baylis
Author: H. Syddall ORCID iD
Author: K.A. Jameson
Author: C. Cooper ORCID iD
Author: M. Lord
Author: H.C. Roberts
Author: A Aihie Sayer

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