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Bone tissue engineering

Bone tissue engineering
Bone tissue engineering
Medical advances have led to a welcome increase in life expectancy. However, accompanying longevity introduces new challenges: increases in age-related diseases and associated reductions in quality of life. The loss of skeletal tissue that can accompany trauma, injury, disease or advancing years can result in significant morbidity and significant socio-economic cost and emphasise the need for new, more reliable skeletal regeneration strategies. To address the unmet need for bone augmentation, tissue engineering and regenerative medicine have come to the fore in recent years with new approaches for de novo skeletal tissue formation. Typically, these approaches seek to harness stem cells, innovative scaffolds and biological factors that promise enhanced and more reliable bone formation strategies to improve the quality of life for many. This review provides an overview of recent developments in bone tissue engineering focusing on skeletal stem cells, vascular development, bone formation and the translation from preclinical in vivo models to clinical delivery.
skeletal stem cell, osteoprogenitor, biomaterial, osteogenesis, translational research, bone tissue regeneration
132-140
Black, Cameron R.M.
7f616e37-4d80-4f60-ac8d-ba96e583db72
Goriainov, Vitali
dc456832-0a5a-4816-8fb7-de132f044a99
Gibbs, David
4e8e4ea5-eaf5-4f93-8baf-88b524885893
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Black, Cameron R.M.
7f616e37-4d80-4f60-ac8d-ba96e583db72
Goriainov, Vitali
dc456832-0a5a-4816-8fb7-de132f044a99
Gibbs, David
4e8e4ea5-eaf5-4f93-8baf-88b524885893
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Black, Cameron R.M., Goriainov, Vitali, Gibbs, David, Kanczler, Janos, Tare, Rahul S. and Oreffo, Richard O.C. (2015) Bone tissue engineering. Current molecular biology reports, 1 (3), 132-140. (doi:10.1007/s40610-015-0022-2). (PMID:26618105)

Record type: Article

Abstract

Medical advances have led to a welcome increase in life expectancy. However, accompanying longevity introduces new challenges: increases in age-related diseases and associated reductions in quality of life. The loss of skeletal tissue that can accompany trauma, injury, disease or advancing years can result in significant morbidity and significant socio-economic cost and emphasise the need for new, more reliable skeletal regeneration strategies. To address the unmet need for bone augmentation, tissue engineering and regenerative medicine have come to the fore in recent years with new approaches for de novo skeletal tissue formation. Typically, these approaches seek to harness stem cells, innovative scaffolds and biological factors that promise enhanced and more reliable bone formation strategies to improve the quality of life for many. This review provides an overview of recent developments in bone tissue engineering focusing on skeletal stem cells, vascular development, bone formation and the translation from preclinical in vivo models to clinical delivery.

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e-pub ahead of print date: 15 August 2015
Published date: September 2015
Keywords: skeletal stem cell, osteoprogenitor, biomaterial, osteogenesis, translational research, bone tissue regeneration
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 384815
URI: https://eprints.soton.ac.uk/id/eprint/384815
PURE UUID: f13ec7c2-b0dc-4825-8729-281858e5d3c7
ORCID for Janos Kanczler: ORCID iD orcid.org/0000-0001-7249-0414
ORCID for Rahul S. Tare: ORCID iD orcid.org/0000-0001-8274-8837
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 13 Jan 2016 11:36
Last modified: 06 Jun 2018 12:53

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Contributors

Author: Cameron R.M. Black
Author: Vitali Goriainov
Author: David Gibbs
Author: Janos Kanczler ORCID iD
Author: Rahul S. Tare ORCID iD

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