The University of Southampton
University of Southampton Institutional Repository

The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice

Record type: Book Section

CD25+ regulatory T cells comprise 5-10% of CD4+ T cells in naïve mice and have been shown in several in vivo murine models to prevent the induction of autoimmune disease and inflammatory disease. Since T cells, which mediate autoimmunity, can through recognition of self-antigens also target tumour cells, it was postulated that CD25+ regulatory cells would also inhibit the generation of immune responses to rumours. Depletion of these cells using CD25-specific monoclonal antibodies has indeed been shown to promote rejection of several transplantable murine tumour cell lines including melanoma, leukaemia and colorectal carcinoma. Results obtained using these models indicate that in the absence of regulatory cells, CD4+ T cells mediate tumour immunity, although the precise mechanisms through which these cells result in tumour rejection have not yet been elucidated. The target antigens recognized by these CD4+ T cells have also not yet been identified. Immunization of mice with tumour cells in the absence of CD25+ regulatory cells does, however, induce immunity against a variety of different tumour cell lines indicating that the target antigen(s) are shared amongst tumours of distinct histological origins. Since CD25+ regulatory cells have been identified in humans, the possibility that the cells inhibit immune responses to shared rejection antigens expressed by human tumours is worthy of investigation.

Full text not available from this repository.

Citation

Jones, Emma, Golgher, Denise, Simon, Anna Katharina, Dahm-Vicker, Michaela, Screaton, Gavin, Elliott, Tim and Gallimore, Awen (2004) The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice In, Chadwick, Derek J. and Goode, Jamie A. (eds.) Cancer and Inflammation. John Wiley & Sons, Ltd (Novartis Foundation Symposia, 256). (doi:10.1002/0470856734.ch11).

More information

Published date: 23 January 2004
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 384924
URI: http://eprints.soton.ac.uk/id/eprint/384924
ISBN: 9780470855102
PURE UUID: 7290d5c7-bd2e-4e30-a13d-65bedae6512d
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222

Catalogue record

Date deposited: 01 Feb 2016 14:24
Last modified: 17 Jul 2017 20:01

Export record

Altmetrics

Contributors

Author: Emma Jones
Author: Denise Golgher
Author: Anna Katharina Simon
Author: Michaela Dahm-Vicker
Author: Gavin Screaton
Author: Tim Elliott ORCID iD
Author: Awen Gallimore
Editor: Derek J. Chadwick
Editor: Jamie A. Goode

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×