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The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice

The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice
The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice
CD25+ regulatory T cells comprise 5-10% of CD4+ T cells in naïve mice and have been shown in several in vivo murine models to prevent the induction of autoimmune disease and inflammatory disease. Since T cells, which mediate autoimmunity, can through recognition of self-antigens also target tumour cells, it was postulated that CD25+ regulatory cells would also inhibit the generation of immune responses to rumours. Depletion of these cells using CD25-specific monoclonal antibodies has indeed been shown to promote rejection of several transplantable murine tumour cell lines including melanoma, leukaemia and colorectal carcinoma. Results obtained using these models indicate that in the absence of regulatory cells, CD4+ T cells mediate tumour immunity, although the precise mechanisms through which these cells result in tumour rejection have not yet been elucidated. The target antigens recognized by these CD4+ T cells have also not yet been identified. Immunization of mice with tumour cells in the absence of CD25+ regulatory cells does, however, induce immunity against a variety of different tumour cell lines indicating that the target antigen(s) are shared amongst tumours of distinct histological origins. Since CD25+ regulatory cells have been identified in humans, the possibility that the cells inhibit immune responses to shared rejection antigens expressed by human tumours is worthy of investigation.
9780470855102
256
John Wiley & Sons, Ltd
Jones, Emma
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Golgher, Denise
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Simon, Anna Katharina
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Dahm-Vicker, Michaela
87ec78fb-5331-440e-8d20-511d6e10612b
Screaton, Gavin
379fb64a-490d-4cc2-958d-80a446043d2b
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Gallimore, Awen
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Chadwick, Derek J.
Goode, Jamie A.
Jones, Emma
dd78e4a0-1029-4a53-a3a4-e622fb3d57c8
Golgher, Denise
9f810d0e-e5f6-48be-84a3-2631ea385816
Simon, Anna Katharina
b6787229-0130-408c-9848-0abfb5092299
Dahm-Vicker, Michaela
87ec78fb-5331-440e-8d20-511d6e10612b
Screaton, Gavin
379fb64a-490d-4cc2-958d-80a446043d2b
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Gallimore, Awen
e0757d8c-28d0-469e-bd74-eaa43567026e
Chadwick, Derek J.
Goode, Jamie A.

Jones, Emma, Golgher, Denise, Simon, Anna Katharina, Dahm-Vicker, Michaela, Screaton, Gavin, Elliott, Tim and Gallimore, Awen (2004) The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice In, Chadwick, Derek J. and Goode, Jamie A. (eds.) Cancer and Inflammation. John Wiley & Sons, Ltd (Novartis Foundation Symposia, 256). (doi:10.1002/0470856734.ch11).

Record type: Book Section

Abstract

CD25+ regulatory T cells comprise 5-10% of CD4+ T cells in naïve mice and have been shown in several in vivo murine models to prevent the induction of autoimmune disease and inflammatory disease. Since T cells, which mediate autoimmunity, can through recognition of self-antigens also target tumour cells, it was postulated that CD25+ regulatory cells would also inhibit the generation of immune responses to rumours. Depletion of these cells using CD25-specific monoclonal antibodies has indeed been shown to promote rejection of several transplantable murine tumour cell lines including melanoma, leukaemia and colorectal carcinoma. Results obtained using these models indicate that in the absence of regulatory cells, CD4+ T cells mediate tumour immunity, although the precise mechanisms through which these cells result in tumour rejection have not yet been elucidated. The target antigens recognized by these CD4+ T cells have also not yet been identified. Immunization of mice with tumour cells in the absence of CD25+ regulatory cells does, however, induce immunity against a variety of different tumour cell lines indicating that the target antigen(s) are shared amongst tumours of distinct histological origins. Since CD25+ regulatory cells have been identified in humans, the possibility that the cells inhibit immune responses to shared rejection antigens expressed by human tumours is worthy of investigation.

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Published date: 23 January 2004
Organisations: Cancer Sciences

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Local EPrints ID: 384924
URI: http://eprints.soton.ac.uk/id/eprint/384924
ISBN: 9780470855102
PURE UUID: 7290d5c7-bd2e-4e30-a13d-65bedae6512d
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222

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Date deposited: 01 Feb 2016 14:24
Last modified: 17 Jul 2017 20:01

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Contributors

Author: Emma Jones
Author: Denise Golgher
Author: Anna Katharina Simon
Author: Michaela Dahm-Vicker
Author: Gavin Screaton
Author: Tim Elliott ORCID iD
Author: Awen Gallimore
Editor: Derek J. Chadwick
Editor: Jamie A. Goode

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