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Molecular chaperones in the mammalian brain: regional distribution, cellular compartmentalization and synaptic interactions

Molecular chaperones in the mammalian brain: regional distribution, cellular compartmentalization and synaptic interactions
Molecular chaperones in the mammalian brain: regional distribution, cellular compartmentalization and synaptic interactions
The expression of molecular chaperones in the human central nervous system (CNS) is not well explored although they regulate key aspects of neuronal functions and likely play crucial roles during chronic neurodegeneration associated with protein misfolding. Current data suggest a rather complex expression profile with a distinct distribution to brain regions and cell types that are further modulated under stress. Synapses represent a particular folding environment due to the many and highly regulated protein interactions that occur in relative isolation. Despite the synaptic localization of several chaperones and proteins with identifiable chaperone modality, we argue that additional synaptic chaperones and chaperone pathways exist that may regulate the synaptic protein homeostasis during protein folding and re-folding. Given the early synapse dysfunction and alterations of chaperone function that occur during CNS diseases associated with protein misfolding, we suggest that further efforts should be made to better define and understand the synaptic “chaperome”.
978-1-4419-7060-2
123-144
Springer
Wyttenbach, Andreas
05019897-52b1-4bb6-b259-5d51abae7540
Quraishe, Shmma
cfc3aed4-f120-41aa-9127-0fc26c657ad2
Bailey, Joanne
23e06daf-d78b-4869-94f0-94baeca110fa
O’Connor, Vincent
3c336b62-f3ef-4f78-a44c-ddc7b47bac3f
Wyttenbach, Andreas
O'Connor, Vincent
Wyttenbach, Andreas
05019897-52b1-4bb6-b259-5d51abae7540
Quraishe, Shmma
cfc3aed4-f120-41aa-9127-0fc26c657ad2
Bailey, Joanne
23e06daf-d78b-4869-94f0-94baeca110fa
O’Connor, Vincent
3c336b62-f3ef-4f78-a44c-ddc7b47bac3f
Wyttenbach, Andreas
O'Connor, Vincent

Wyttenbach, Andreas, Quraishe, Shmma, Bailey, Joanne and O’Connor, Vincent (2011) Molecular chaperones in the mammalian brain: regional distribution, cellular compartmentalization and synaptic interactions. In, Wyttenbach, Andreas and O'Connor, Vincent (eds.) Folding for the Synapse. Part III. New York, US. Springer, pp. 123-144. (doi:10.1007/978-1-4419-7061-9_7).

Record type: Book Section

Abstract

The expression of molecular chaperones in the human central nervous system (CNS) is not well explored although they regulate key aspects of neuronal functions and likely play crucial roles during chronic neurodegeneration associated with protein misfolding. Current data suggest a rather complex expression profile with a distinct distribution to brain regions and cell types that are further modulated under stress. Synapses represent a particular folding environment due to the many and highly regulated protein interactions that occur in relative isolation. Despite the synaptic localization of several chaperones and proteins with identifiable chaperone modality, we argue that additional synaptic chaperones and chaperone pathways exist that may regulate the synaptic protein homeostasis during protein folding and re-folding. Given the early synapse dysfunction and alterations of chaperone function that occur during CNS diseases associated with protein misfolding, we suggest that further efforts should be made to better define and understand the synaptic “chaperome”.

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Published date: 2011
Organisations: Centre for Biological Sciences

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Local EPrints ID: 385003
URI: http://eprints.soton.ac.uk/id/eprint/385003
ISBN: 978-1-4419-7060-2
PURE UUID: f2e672ce-2281-42fc-9552-392f9853e0c0

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Date deposited: 11 Dec 2015 16:08
Last modified: 15 Jul 2019 20:54

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