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Non-invasive assessment of lower limb geometry and strength using hip structural analysis and peripheral quantitative computed tomography: a population-based comparison

Non-invasive assessment of lower limb geometry and strength using hip structural analysis and peripheral quantitative computed tomography: a population-based comparison
Non-invasive assessment of lower limb geometry and strength using hip structural analysis and peripheral quantitative computed tomography: a population-based comparison
Hip fracture is the most significant complication of osteoporosis in terms of mortality, long-term disability and decreased quality of life. In the recent years, different techniques have been developed to assess lower limb strength and ultimately fracture risk. Here we examine relationships between two measures of lower limb bone geometry and strength; proximal femoral geometry and tibial peripheral quantitative computed tomography. We studied a sample of 431 women and 488 men aged in the range 59–71 years. The hip structural analysis (HSA) programme was employed to measure the structural geometry of the left hip for each DXA scan obtained using a Hologic QDR 4500 instrument while pQCT measurements of the tibia were obtained using a Stratec 2000 instrument in the same population. We observed strong sex differences in proximal femoral geometry at the narrow neck, intertrochanteric and femoral shaft regions. There were significant (p < 0.001) associations between pQCT-derived measures of bone geometry (tibial width; endocortical diameter and cortical thickness) and bone strength (strength strain index) with each corresponding HSA variable (all p < 0.001) in both men and women. These results demonstrate strong correlations between two different methods of assessment of lower limb bone strength: HSA and pQCT. Validation in prospective cohorts to study associations of each with incident fracture is now indicated.
osteoporosis, epidemiology, hip structural analysis, peripheral quantitative computed tomography
0171-967X
158-164
Litwic, A.E.
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Clynes, M.
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Denison, H.J.
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Jameson, K.A.
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Edwards, M.H.
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Sayer, A.A.
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Taylor, P.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Litwic, A.E.
5faa3ead-e7d1-4b1a-aa2d-f79444fa11e9
Clynes, M.
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Denison, H.J.
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Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Sayer, A.A.
f4c60d4a-ae9c-4633-890f-598a717a61d4
Taylor, P.
28b91e71-fad2-4375-8a1e-535f861901c3
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1

Litwic, A.E., Clynes, M., Denison, H.J., Jameson, K.A., Edwards, M.H., Sayer, A.A., Taylor, P., Cooper, C. and Dennison, E.M. (2016) Non-invasive assessment of lower limb geometry and strength using hip structural analysis and peripheral quantitative computed tomography: a population-based comparison. Calcified Tissue International, 98 (2), 158-164. (doi:10.1007/s00223-015-0081-7). (PMID:26590812)

Record type: Article

Abstract

Hip fracture is the most significant complication of osteoporosis in terms of mortality, long-term disability and decreased quality of life. In the recent years, different techniques have been developed to assess lower limb strength and ultimately fracture risk. Here we examine relationships between two measures of lower limb bone geometry and strength; proximal femoral geometry and tibial peripheral quantitative computed tomography. We studied a sample of 431 women and 488 men aged in the range 59–71 years. The hip structural analysis (HSA) programme was employed to measure the structural geometry of the left hip for each DXA scan obtained using a Hologic QDR 4500 instrument while pQCT measurements of the tibia were obtained using a Stratec 2000 instrument in the same population. We observed strong sex differences in proximal femoral geometry at the narrow neck, intertrochanteric and femoral shaft regions. There were significant (p < 0.001) associations between pQCT-derived measures of bone geometry (tibial width; endocortical diameter and cortical thickness) and bone strength (strength strain index) with each corresponding HSA variable (all p < 0.001) in both men and women. These results demonstrate strong correlations between two different methods of assessment of lower limb bone strength: HSA and pQCT. Validation in prospective cohorts to study associations of each with incident fracture is now indicated.

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Accepted/In Press date: 6 November 2015
e-pub ahead of print date: 21 November 2015
Published date: February 2016
Keywords: osteoporosis, epidemiology, hip structural analysis, peripheral quantitative computed tomography
Organisations: Faculty of Medicine

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Local EPrints ID: 385092
URI: http://eprints.soton.ac.uk/id/eprint/385092
ISSN: 0171-967X
PURE UUID: 8a5b5961-3f57-4bd8-9538-42fc11442f66
ORCID for M. Clynes: ORCID iD orcid.org/0000-0001-7597-7658
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961

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Date deposited: 14 Jan 2016 13:16
Last modified: 26 Nov 2019 02:00

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Contributors

Author: A.E. Litwic
Author: M. Clynes ORCID iD
Author: H.J. Denison
Author: K.A. Jameson
Author: M.H. Edwards
Author: A.A. Sayer
Author: P. Taylor
Author: C. Cooper ORCID iD
Author: E.M. Dennison ORCID iD

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