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Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS).

Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS).
Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS).
BACKGROUND: Sarcopenia is defined as the loss of muscle mass and function with age and is associated with decline in mobility, frailty, falls and mortality. There is considerable interest in understanding the underlying mechanisms. Our aim was to characterise muscle morphology changes associated with sarcopenia among community dwelling older men.

METHODS: One hundred and five men aged 68-76 years were recruited to the Hertfordshire Sarcopenia Study (HSS) for detailed characterisation of muscle including measures of muscle mass, strength and function. Muscle tissue was obtained from a biopsy of the vastus lateralis for 99 men and was processed for immunohistochemical studies to determine myofibre distribution and area, capillarisation and satellite cell (SC) density.

RESULTS: Six (6 %) men had sarcopenia as defined by the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. These men had lower SC density (1.7 cells/mm(2) vs 3.8 cells/mm(2), p?=?0.06) and lower SC/fibre ratio (0.02 vs 0.06, p?=?0.06) than men without sarcopenia. Although men with sarcopenia tended to have smaller myofibres and lower capillary to fibre ratio, these relationships were not statistically significant.

CONCLUSION: We have shown that there may be altered muscle morphology parameters in older men with sarcopenia. These results have the potential to help identify cell and molecular targets for therapeutic intervention. This work now requires extension to larger studies which also include women.
sarcopenia, muscle morphology, community dwelling older men
1471-2318
1-6
Patel, H.P.
6a3fce01-9f35-468a-8dce-38b31d3a60fa
White, M.C.
43bc0ee4-8420-48e7-be4a-b2a51442dab1
Westbury, L.
5ed45df3-3df7-4bf9-bbad-07b63cd4b281
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Stephens, P.J.
6565a5c4-5cbf-4e35-be4c-ac629c903199
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, A.A.
f4c60d4a-ae9c-4633-890f-598a717a61d4
Patel, H.P.
6a3fce01-9f35-468a-8dce-38b31d3a60fa
White, M.C.
43bc0ee4-8420-48e7-be4a-b2a51442dab1
Westbury, L.
5ed45df3-3df7-4bf9-bbad-07b63cd4b281
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Stephens, P.J.
6565a5c4-5cbf-4e35-be4c-ac629c903199
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, A.A.
f4c60d4a-ae9c-4633-890f-598a717a61d4

Patel, H.P., White, M.C., Westbury, L., Syddall, H.E., Stephens, P.J., Clough, G.F., Cooper, C. and Sayer, A.A. (2015) Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS). BMC Geriatrics, 15 (171), 1-6. (doi:10.1186/s12877-015-0171-4). (PMID:26678672)

Record type: Article

Abstract

BACKGROUND: Sarcopenia is defined as the loss of muscle mass and function with age and is associated with decline in mobility, frailty, falls and mortality. There is considerable interest in understanding the underlying mechanisms. Our aim was to characterise muscle morphology changes associated with sarcopenia among community dwelling older men.

METHODS: One hundred and five men aged 68-76 years were recruited to the Hertfordshire Sarcopenia Study (HSS) for detailed characterisation of muscle including measures of muscle mass, strength and function. Muscle tissue was obtained from a biopsy of the vastus lateralis for 99 men and was processed for immunohistochemical studies to determine myofibre distribution and area, capillarisation and satellite cell (SC) density.

RESULTS: Six (6 %) men had sarcopenia as defined by the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. These men had lower SC density (1.7 cells/mm(2) vs 3.8 cells/mm(2), p?=?0.06) and lower SC/fibre ratio (0.02 vs 0.06, p?=?0.06) than men without sarcopenia. Although men with sarcopenia tended to have smaller myofibres and lower capillary to fibre ratio, these relationships were not statistically significant.

CONCLUSION: We have shown that there may be altered muscle morphology parameters in older men with sarcopenia. These results have the potential to help identify cell and molecular targets for therapeutic intervention. This work now requires extension to larger studies which also include women.

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Accepted/In Press date: 10 December 2015
Published date: 18 December 2015
Keywords: sarcopenia, muscle morphology, community dwelling older men
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 385290
URI: http://eprints.soton.ac.uk/id/eprint/385290
ISSN: 1471-2318
PURE UUID: 03871b14-c8d7-4b0b-be42-a6da0ae785f5
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for G.F. Clough: ORCID iD orcid.org/0000-0002-6226-8964
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 18 Jan 2016 16:12
Last modified: 07 Oct 2020 01:42

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Contributors

Author: H.P. Patel
Author: M.C. White
Author: L. Westbury
Author: H.E. Syddall ORCID iD
Author: P.J. Stephens
Author: G.F. Clough ORCID iD
Author: C. Cooper ORCID iD
Author: A.A. Sayer

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