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Early growth and changes in blood pressure during adult life

Early growth and changes in blood pressure during adult life
Early growth and changes in blood pressure during adult life
Previous studies suggest that the inverse association between birth weight and adult blood pressure amplifies with age. Rapid childhood growth has also been linked to hypertension. The objective of this study was to determine whether the association between childhood growth and adult blood pressure amplifies with age. The study comprised 574 women and 462 men from the Helsinki Birth Cohort Study who attended a clinical study in 2001–2004 and a follow-up in 2006–2008. Mean age at the clinic visits was 61.5 and 66.4 years, respectively. Blood pressure was measured at both occasions. Conditional growth models were used to assess relative weight gain and linear growth. We studied the associations between conditional growth and blood pressure as well as the presence of hypertension. Relative weight gain and linear growth between ages 2 and 11 years were inversely associated with systolic blood pressure at mean age 66.4 years, after adjustment for sex, blood pressure at mean age 61.5 years, as well as other covariates. A one s.d. increase in linear growth between 2 and 11 years was associated with an OR of 0.61 for hypertension at mean age 66.4 years. Contrary to previous studies, we have shown an inverse association between childhood growth and adult blood pressure. There were, however, no associations between childhood growth and systolic blood pressure at mean age 61.5 years indicating that the beneficial effects of a more rapid than expected childhood growth might become more apparent with increasing age.
blood pressure, foetal programming, growth, hypertension
1-8
Sandboge, S.
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Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Sandboge, S.
60effc3d-f537-49c1-b675-960c60d4383e
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b

Sandboge, S., Osmond, C., Kajantie, E. and Eriksson, J.G. (2015) Early growth and changes in blood pressure during adult life. Journal of Developmental Origins of Health and Disease, 1-8. (doi:10.1017/S2040174415007886). (PMID:26654274)

Record type: Article

Abstract

Previous studies suggest that the inverse association between birth weight and adult blood pressure amplifies with age. Rapid childhood growth has also been linked to hypertension. The objective of this study was to determine whether the association between childhood growth and adult blood pressure amplifies with age. The study comprised 574 women and 462 men from the Helsinki Birth Cohort Study who attended a clinical study in 2001–2004 and a follow-up in 2006–2008. Mean age at the clinic visits was 61.5 and 66.4 years, respectively. Blood pressure was measured at both occasions. Conditional growth models were used to assess relative weight gain and linear growth. We studied the associations between conditional growth and blood pressure as well as the presence of hypertension. Relative weight gain and linear growth between ages 2 and 11 years were inversely associated with systolic blood pressure at mean age 66.4 years, after adjustment for sex, blood pressure at mean age 61.5 years, as well as other covariates. A one s.d. increase in linear growth between 2 and 11 years was associated with an OR of 0.61 for hypertension at mean age 66.4 years. Contrary to previous studies, we have shown an inverse association between childhood growth and adult blood pressure. There were, however, no associations between childhood growth and systolic blood pressure at mean age 61.5 years indicating that the beneficial effects of a more rapid than expected childhood growth might become more apparent with increasing age.

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More information

Accepted/In Press date: 2 November 2015
e-pub ahead of print date: 10 December 2015
Keywords: blood pressure, foetal programming, growth, hypertension
Organisations: Faculty of Medicine

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Local EPrints ID: 385326
URI: http://eprints.soton.ac.uk/id/eprint/385326
PURE UUID: 4596fdac-7709-44d2-9dd6-0d5b01559498
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 19 Jan 2016 09:21
Last modified: 17 Apr 2021 01:36

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Contributors

Author: S. Sandboge
Author: C. Osmond ORCID iD
Author: E. Kajantie
Author: J.G. Eriksson

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